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Circulating angiogenic cytokines and stem cells in patients with severe chronic ischemic heart disease - Indicators of myocardial ischemic burden?

Ripa, Rasmus Sejersten; Wang, Yongzhong; Goetze, Jens Peter; Jorgensen, Erik; Johnsen, Hans E.; Tägil, Kristina LU ; Hesse, Birger and Kastrup, Jens (2007) In International Journal of Cardiology 120(2). p.181-187
Abstract
Background: Angiogenic growth factors and stem cell therapies have demonstrated varying results in patients with chronic coronary artery disease. A reason could be that these mechanisms are already up-regulated due to reduced blood supply to the myocardium. The objective of this study was to examine if plasma concentrations of circulating stem cells and angiogenic cytokines in patients with severe stable chronic coronary artery disease were correlated to the clinical severity of the disease. Methods: Fifty-four patients with severe coronary artery disease and reversible ischemia at stress myocardial perfusion scintigraphy were prospectively included. The severity of the disease was quantified by an exercise tolerance test, Canadian... (More)
Background: Angiogenic growth factors and stem cell therapies have demonstrated varying results in patients with chronic coronary artery disease. A reason could be that these mechanisms are already up-regulated due to reduced blood supply to the myocardium. The objective of this study was to examine if plasma concentrations of circulating stem cells and angiogenic cytokines in patients with severe stable chronic coronary artery disease were correlated to the clinical severity of the disease. Methods: Fifty-four patients with severe coronary artery disease and reversible ischemia at stress myocardial perfusion scintigraphy were prospectively included. The severity of the disease was quantified by an exercise tolerance test, Canadian Cardiovascular Society angina classification, and Seattle Angina Pectoris Questionnaire. Fifteen persons without coronary artery disease served as control subjects. Results: Plasma concentration of VEGF-A, FGF-2, SDF-1, and circulating CD34+ and CD34-/CD45-cells were similar in the two groups, but early stem cell markers (CD105, CD73, CD166) and endothelial markers (CD31, CD144, VEGFR2) were significantly different between patients and control subjects (p < 0.005- 0.001). Diabetic patients had higher concentration of SDF-1 (2528 vs. 2150 pg/ml, p= 0.004). We found significant correlations between both VEGF-A, FGF-2, and CD34+ to disease severity, including degree of reversible ischemia, angina stability score, and exertional dyspnoea. Conclusions: Plasma concentrations of circulating stem cells and angiogenic cytokines have large inter-individual variations, which probably exclude them from being useful as indicators of myocardial ischemic burden. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diabetes, mesenchymal stem cell, endothelial progenitor cell, ischemic heart disease, angiogenesis
in
International Journal of Cardiology
volume
120
issue
2
pages
181 - 187
publisher
Elsevier
external identifiers
  • wos:000248106600007
  • scopus:34447282760
ISSN
0167-5273
DOI
10.1016/j.ijcard.2006.09.011
language
English
LU publication?
yes
id
2e82c8ea-6d98-4d3a-a2ce-72233373a05c (old id 645734)
date added to LUP
2007-12-14 11:50:32
date last changed
2017-01-01 04:58:36
@article{2e82c8ea-6d98-4d3a-a2ce-72233373a05c,
  abstract     = {Background: Angiogenic growth factors and stem cell therapies have demonstrated varying results in patients with chronic coronary artery disease. A reason could be that these mechanisms are already up-regulated due to reduced blood supply to the myocardium. The objective of this study was to examine if plasma concentrations of circulating stem cells and angiogenic cytokines in patients with severe stable chronic coronary artery disease were correlated to the clinical severity of the disease. Methods: Fifty-four patients with severe coronary artery disease and reversible ischemia at stress myocardial perfusion scintigraphy were prospectively included. The severity of the disease was quantified by an exercise tolerance test, Canadian Cardiovascular Society angina classification, and Seattle Angina Pectoris Questionnaire. Fifteen persons without coronary artery disease served as control subjects. Results: Plasma concentration of VEGF-A, FGF-2, SDF-1, and circulating CD34+ and CD34-/CD45-cells were similar in the two groups, but early stem cell markers (CD105, CD73, CD166) and endothelial markers (CD31, CD144, VEGFR2) were significantly different between patients and control subjects (p &lt; 0.005- 0.001). Diabetic patients had higher concentration of SDF-1 (2528 vs. 2150 pg/ml, p= 0.004). We found significant correlations between both VEGF-A, FGF-2, and CD34+ to disease severity, including degree of reversible ischemia, angina stability score, and exertional dyspnoea. Conclusions: Plasma concentrations of circulating stem cells and angiogenic cytokines have large inter-individual variations, which probably exclude them from being useful as indicators of myocardial ischemic burden.},
  author       = {Ripa, Rasmus Sejersten and Wang, Yongzhong and Goetze, Jens Peter and Jorgensen, Erik and Johnsen, Hans E. and Tägil, Kristina and Hesse, Birger and Kastrup, Jens},
  issn         = {0167-5273},
  keyword      = {diabetes,mesenchymal stem cell,endothelial progenitor cell,ischemic heart disease,angiogenesis},
  language     = {eng},
  number       = {2},
  pages        = {181--187},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Circulating angiogenic cytokines and stem cells in patients with severe chronic ischemic heart disease - Indicators of myocardial ischemic burden?},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2006.09.011},
  volume       = {120},
  year         = {2007},
}