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Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study

Engström, Gunnar LU ; Hedblad, Bo LU ; Janzon, Lars LU and Lindgärde, Folke LU (2007) In European Journal of Cardiovascular Prevention & Rehabilitation 14(3). p.392-397
Abstract
Background Complement factor C3 and C4 have been associated with atherosclerosis and cardiovascular risk factors. This study explored whether plasma levels of C3 and C4 are risk factors for the incidence of cardiovascular disease (CVD). Design A population-based prospective study of 5850 initially healthy men, 28-61 years old at baseline. Methods Plasma levels of C3 and C4 were analysed at the baseline examination. The incidence of coronary events (i.e. fatal or non-fatal myocardial infarction), ischaemic stroke and cardiovascular events (i.e. myocardial infarction, ischaemic stroke or cardiovascular death) was studied over 18 years of follow-up. Results Adjusted for age, C3 in the fourth quartile (versus the first quartile) was associated... (More)
Background Complement factor C3 and C4 have been associated with atherosclerosis and cardiovascular risk factors. This study explored whether plasma levels of C3 and C4 are risk factors for the incidence of cardiovascular disease (CVD). Design A population-based prospective study of 5850 initially healthy men, 28-61 years old at baseline. Methods Plasma levels of C3 and C4 were analysed at the baseline examination. The incidence of coronary events (i.e. fatal or non-fatal myocardial infarction), ischaemic stroke and cardiovascular events (i.e. myocardial infarction, ischaemic stroke or cardiovascular death) was studied over 18 years of follow-up. Results Adjusted for age, C3 in the fourth quartile (versus the first quartile) was associated with an increased incidence of coronary events [relative risk (RR) 1.54, 95% confidence interval (CI) 1.2-1.91, cardiovascular events (RR 1.56, 95% CI 1.3-1.9), and non-significantly with the incidence of ischaemic stroke (RR 1.31, 95% CI 0.89-1.8). However, after adjustments for smoking, body mass index (BMI), cholesterol, diabetes and systolic blood pressure, these relationships were completely attenuated and non-significant. The relationships were similar for C4 concentrations within the normal range. However, for men with C4 in the top 10% of the distribution (>0.34 g/l), a significantly increased incidence of coronary events was found, which persisted after adjustments for risk factors. Conclusion C3 and C4 show substantial correlations with cardiovascular risk factors, including blood pressure, BMI, and lipids. This relationship accounts for the increased incidence of CVD in men with high C3 levels. However, very high C4 levels may be associated with the incidence of CVD, independently of traditional cardiovascular risk factors. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myocardial infarction, inflammation, epidemiology, C4, complement, C3, stroke
in
European Journal of Cardiovascular Prevention & Rehabilitation
volume
14
issue
3
pages
392 - 397
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000247822100007
  • scopus:34250649678
ISSN
1741-8275
DOI
10.1097/01.hjr.0000244582.30421.b2
language
English
LU publication?
yes
id
a7a2d53e-c779-4886-989f-f70371db5215 (old id 645803)
alternative location
http://www.jcardiovascularrisk.com/pt/re/ejcpr/abstract.00149831-200706000-00007.htm
date added to LUP
2007-12-11 20:11:17
date last changed
2017-10-29 03:40:13
@article{a7a2d53e-c779-4886-989f-f70371db5215,
  abstract     = {Background Complement factor C3 and C4 have been associated with atherosclerosis and cardiovascular risk factors. This study explored whether plasma levels of C3 and C4 are risk factors for the incidence of cardiovascular disease (CVD). Design A population-based prospective study of 5850 initially healthy men, 28-61 years old at baseline. Methods Plasma levels of C3 and C4 were analysed at the baseline examination. The incidence of coronary events (i.e. fatal or non-fatal myocardial infarction), ischaemic stroke and cardiovascular events (i.e. myocardial infarction, ischaemic stroke or cardiovascular death) was studied over 18 years of follow-up. Results Adjusted for age, C3 in the fourth quartile (versus the first quartile) was associated with an increased incidence of coronary events [relative risk (RR) 1.54, 95% confidence interval (CI) 1.2-1.91, cardiovascular events (RR 1.56, 95% CI 1.3-1.9), and non-significantly with the incidence of ischaemic stroke (RR 1.31, 95% CI 0.89-1.8). However, after adjustments for smoking, body mass index (BMI), cholesterol, diabetes and systolic blood pressure, these relationships were completely attenuated and non-significant. The relationships were similar for C4 concentrations within the normal range. However, for men with C4 in the top 10% of the distribution (>0.34 g/l), a significantly increased incidence of coronary events was found, which persisted after adjustments for risk factors. Conclusion C3 and C4 show substantial correlations with cardiovascular risk factors, including blood pressure, BMI, and lipids. This relationship accounts for the increased incidence of CVD in men with high C3 levels. However, very high C4 levels may be associated with the incidence of CVD, independently of traditional cardiovascular risk factors.},
  author       = {Engström, Gunnar and Hedblad, Bo and Janzon, Lars and Lindgärde, Folke},
  issn         = {1741-8275},
  keyword      = {myocardial infarction,inflammation,epidemiology,C4,complement,C3,stroke},
  language     = {eng},
  number       = {3},
  pages        = {392--397},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cardiovascular Prevention & Rehabilitation},
  title        = {Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study},
  url          = {http://dx.doi.org/10.1097/01.hjr.0000244582.30421.b2},
  volume       = {14},
  year         = {2007},
}