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Pharmacodynamic studies of vancomycin, metronidazole and fusidic acid against Clostridium difficile

Odenholt, Inga LU ; Walder, Mats LU and Wullt, Marlene LU (2007) In Chemotherapy 53(4). p.267-274
Abstract
Background: Pharmacodynamic studies of antibiotics have attracted great interest in recent years. However, studies on the pharmacodynamics of different antibiotics against Clostridium difficile are scarce. Methods: The postantibiotic effects (PAE) and the postantibiotic sub-minimum inhibitory concentration (MIC) effects (PA SME) of vancomycin, metronidazole and fusidic acid were investigated by viable counts against three different strains of C. difficile. The killing rate and extent of the three antibiotics against the same strains were also studied by adding 2, 4, 8, 16 and 32 ! MIC of the three antibiotics, respectively. Results: Metronidazole exerted a very rapid bactericidal effect at concentrations of 8 ! MIC and above against all... (More)
Background: Pharmacodynamic studies of antibiotics have attracted great interest in recent years. However, studies on the pharmacodynamics of different antibiotics against Clostridium difficile are scarce. Methods: The postantibiotic effects (PAE) and the postantibiotic sub-minimum inhibitory concentration (MIC) effects (PA SME) of vancomycin, metronidazole and fusidic acid were investigated by viable counts against three different strains of C. difficile. The killing rate and extent of the three antibiotics against the same strains were also studied by adding 2, 4, 8, 16 and 32 ! MIC of the three antibiotics, respectively. Results: Metronidazole exerted a very rapid bactericidal effect at concentrations of 8 ! MIC and above against all three strains investigated. Vancomycin gave overall less kill in comparison to metronidazole and was bacteriostatic against two of the three strains. Fusidic acid exerted a concentration-dependent killing against two of the strains. Vancomycin exerted short PAEs and PA SMEs against all three strains. Significantly longer PAEs and PA SMEs were noted for fusidic acid. Metronidazole gave similar short PAEs like vancomycin but longer PA SMEs were noted against two of the investigated strains. Conclusion: Metronidazole exerted the most prominent bactericidal effect greater than fusidic acid and greater than vancomycin. Fusidic acid gave overall the longest PAEs and PA SMEs greater than metronidazole and greater than vancomycin. Copyright (C) 2007 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fusidic acid, vancomycin, metronidazole, Clostridium difficile, effect, postantibiotic sub-MIC, pharmacodynamic effect, postantibiotic effect
in
Chemotherapy
volume
53
issue
4
pages
267 - 274
publisher
Karger
external identifiers
  • wos:000248071900004
  • scopus:34447513074
ISSN
0009-3157
DOI
10.1159/000104471
language
English
LU publication?
yes
id
69aaa8d0-a514-4ee0-81f0-418ae092a921 (old id 645886)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17595541&dopt=Abstract
date added to LUP
2007-12-17 16:27:06
date last changed
2017-01-01 06:52:05
@article{69aaa8d0-a514-4ee0-81f0-418ae092a921,
  abstract     = {Background: Pharmacodynamic studies of antibiotics have attracted great interest in recent years. However, studies on the pharmacodynamics of different antibiotics against Clostridium difficile are scarce. Methods: The postantibiotic effects (PAE) and the postantibiotic sub-minimum inhibitory concentration (MIC) effects (PA SME) of vancomycin, metronidazole and fusidic acid were investigated by viable counts against three different strains of C. difficile. The killing rate and extent of the three antibiotics against the same strains were also studied by adding 2, 4, 8, 16 and 32 ! MIC of the three antibiotics, respectively. Results: Metronidazole exerted a very rapid bactericidal effect at concentrations of 8 ! MIC and above against all three strains investigated. Vancomycin gave overall less kill in comparison to metronidazole and was bacteriostatic against two of the three strains. Fusidic acid exerted a concentration-dependent killing against two of the strains. Vancomycin exerted short PAEs and PA SMEs against all three strains. Significantly longer PAEs and PA SMEs were noted for fusidic acid. Metronidazole gave similar short PAEs like vancomycin but longer PA SMEs were noted against two of the investigated strains. Conclusion: Metronidazole exerted the most prominent bactericidal effect greater than fusidic acid and greater than vancomycin. Fusidic acid gave overall the longest PAEs and PA SMEs greater than metronidazole and greater than vancomycin. Copyright (C) 2007 S. Karger AG, Basel.},
  author       = {Odenholt, Inga and Walder, Mats and Wullt, Marlene},
  issn         = {0009-3157},
  keyword      = {fusidic acid,vancomycin,metronidazole,Clostridium difficile,effect,postantibiotic sub-MIC,pharmacodynamic effect,postantibiotic effect},
  language     = {eng},
  number       = {4},
  pages        = {267--274},
  publisher    = {Karger},
  series       = {Chemotherapy},
  title        = {Pharmacodynamic studies of vancomycin, metronidazole and fusidic acid against Clostridium difficile},
  url          = {http://dx.doi.org/10.1159/000104471},
  volume       = {53},
  year         = {2007},
}