Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread
(2007) In Cancer Biotherapy & Radiopharmaceuticals 22(3). p.357-366- Abstract
- Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of the Raji cells. The radius of the nucleus was assumed to be 75% of the cellular radius. The electron energies were 18, 28, and 190 keV, corresponding to the mean electron energy per decay for I-125, I-123, and I-131, respectively. S-values for different activity distributions were simulated using Monte Carlo and dose-volume histograms as well as... (More)
- Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of the Raji cells. The radius of the nucleus was assumed to be 75% of the cellular radius. The electron energies were 18, 28, and 190 keV, corresponding to the mean electron energy per decay for I-125, I-123, and I-131, respectively. S-values for different activity distributions were simulated using Monte Carlo and dose-volume histograms as well as absorbed doses, and absorbed dose rates were calculated. Results: I-125 gives the highest absorbed dose (similar to 4-40 times that of I-131), whereas I-123 Will give the highest absorbed dose rate (similar to 100 times that of I-131). Under the given assumptions, the absorbed dose at this level is more dependent on the Size of the cells than on whether the radioimmunoconjugate is internalized. Conclusions: This enquiry showed that both I-123 and I-125 have greater potential than I-131 for the treatment of leukemic spread in patients With lymphoma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/645902
- author
- Hindorf, Cecilia LU ; Emfietzoglou, Dimitris ; Lindén, Ola LU ; Bousis, Christos ; Fotopoulos, Andreas ; Kostarelos, Kostas and Flux, Glenn D.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- single cells, dosimetry, lymphoma
- in
- Cancer Biotherapy & Radiopharmaceuticals
- volume
- 22
- issue
- 3
- pages
- 357 - 366
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- wos:000248040500006
- scopus:34447515726
- ISSN
- 1557-8852
- DOI
- 10.1089/cbr.2007.347
- language
- English
- LU publication?
- yes
- id
- bfd0c6bc-be65-43d8-b9e4-aa1cf130f504 (old id 645902)
- date added to LUP
- 2016-04-01 16:57:06
- date last changed
- 2022-03-22 22:18:34
@article{bfd0c6bc-be65-43d8-b9e4-aa1cf130f504,
abstract = {{Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of the Raji cells. The radius of the nucleus was assumed to be 75% of the cellular radius. The electron energies were 18, 28, and 190 keV, corresponding to the mean electron energy per decay for I-125, I-123, and I-131, respectively. S-values for different activity distributions were simulated using Monte Carlo and dose-volume histograms as well as absorbed doses, and absorbed dose rates were calculated. Results: I-125 gives the highest absorbed dose (similar to 4-40 times that of I-131), whereas I-123 Will give the highest absorbed dose rate (similar to 100 times that of I-131). Under the given assumptions, the absorbed dose at this level is more dependent on the Size of the cells than on whether the radioimmunoconjugate is internalized. Conclusions: This enquiry showed that both I-123 and I-125 have greater potential than I-131 for the treatment of leukemic spread in patients With lymphoma.}},
author = {{Hindorf, Cecilia and Emfietzoglou, Dimitris and Lindén, Ola and Bousis, Christos and Fotopoulos, Andreas and Kostarelos, Kostas and Flux, Glenn D.}},
issn = {{1557-8852}},
keywords = {{single cells; dosimetry; lymphoma}},
language = {{eng}},
number = {{3}},
pages = {{357--366}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Cancer Biotherapy & Radiopharmaceuticals}},
title = {{Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread}},
url = {{http://dx.doi.org/10.1089/cbr.2007.347}},
doi = {{10.1089/cbr.2007.347}},
volume = {{22}},
year = {{2007}},
}