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Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread

Hindorf, Cecilia LU ; Emfietzoglou, Dimitris; Lindén, Ola LU ; Bousis, Christos; Fotopoulos, Andreas; Kostarelos, Kostas and Flux, Glenn D. (2007) In Cancer Biotherapy & Radiopharmaceuticals 22(3). p.357-366
Abstract
Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of the Raji cells. The radius of the nucleus was assumed to be 75% of the cellular radius. The electron energies were 18, 28, and 190 keV, corresponding to the mean electron energy per decay for I-125, I-123, and I-131, respectively. S-values for different activity distributions were simulated using Monte Carlo and dose-volume histograms as well as... (More)
Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of the Raji cells. The radius of the nucleus was assumed to be 75% of the cellular radius. The electron energies were 18, 28, and 190 keV, corresponding to the mean electron energy per decay for I-125, I-123, and I-131, respectively. S-values for different activity distributions were simulated using Monte Carlo and dose-volume histograms as well as absorbed doses, and absorbed dose rates were calculated. Results: I-125 gives the highest absorbed dose (similar to 4-40 times that of I-131), whereas I-123 Will give the highest absorbed dose rate (similar to 100 times that of I-131). Under the given assumptions, the absorbed dose at this level is more dependent on the Size of the cells than on whether the radioimmunoconjugate is internalized. Conclusions: This enquiry showed that both I-123 and I-125 have greater potential than I-131 for the treatment of leukemic spread in patients With lymphoma. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
single cells, dosimetry, lymphoma
in
Cancer Biotherapy & Radiopharmaceuticals
volume
22
issue
3
pages
357 - 366
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000248040500006
  • scopus:34447515726
ISSN
1557-8852
DOI
10.1089/cbr.2007.347
language
English
LU publication?
yes
id
bfd0c6bc-be65-43d8-b9e4-aa1cf130f504 (old id 645902)
date added to LUP
2007-12-12 14:00:51
date last changed
2017-08-06 04:39:50
@article{bfd0c6bc-be65-43d8-b9e4-aa1cf130f504,
  abstract     = {Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of the Raji cells. The radius of the nucleus was assumed to be 75% of the cellular radius. The electron energies were 18, 28, and 190 keV, corresponding to the mean electron energy per decay for I-125, I-123, and I-131, respectively. S-values for different activity distributions were simulated using Monte Carlo and dose-volume histograms as well as absorbed doses, and absorbed dose rates were calculated. Results: I-125 gives the highest absorbed dose (similar to 4-40 times that of I-131), whereas I-123 Will give the highest absorbed dose rate (similar to 100 times that of I-131). Under the given assumptions, the absorbed dose at this level is more dependent on the Size of the cells than on whether the radioimmunoconjugate is internalized. Conclusions: This enquiry showed that both I-123 and I-125 have greater potential than I-131 for the treatment of leukemic spread in patients With lymphoma.},
  author       = {Hindorf, Cecilia and Emfietzoglou, Dimitris and Lindén, Ola and Bousis, Christos and Fotopoulos, Andreas and Kostarelos, Kostas and Flux, Glenn D.},
  issn         = {1557-8852},
  keyword      = {single cells,dosimetry,lymphoma},
  language     = {eng},
  number       = {3},
  pages        = {357--366},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Cancer Biotherapy & Radiopharmaceuticals},
  title        = {Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread},
  url          = {http://dx.doi.org/10.1089/cbr.2007.347},
  volume       = {22},
  year         = {2007},
}