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Mouse S-factors based on monte carlo simulations in the anatomical realistic Moby phantom for internal dosimetry

Larsson, Erik LU ; Strand, Sven-Erik LU ; Ljungberg, Michael LU and Jönsson, Bo-Anders LU (2007) In Cancer Biotherapy & Radiopharmaceuticals 22(3). p.438-442
Abstract
Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phantom, as compared to previously mathematically described phantoms, based mainly on ellipsoids and cylinders. The difference in results from the two Monte Carlo codes, EGS4 and MCNPX 2.6a, was also evaluated. Methods: An anatomical correct mouse phantom (Moby) was developed by Segars et al. for the evaluation and optimization of the in vivo imaging... (More)
Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phantom, as compared to previously mathematically described phantoms, based mainly on ellipsoids and cylinders. The difference in results from the two Monte Carlo codes, EGS4 and MCNPX 2.6a, was also evaluated. Methods: An anatomical correct mouse phantom (Moby) was developed by Segars et al. for the evaluation and optimization of the in vivo imaging of mice. The Moby phantom is based on surfaces, which allows for an easy and flexible definition of organ sizes. It includes respiratory movements and a beating heart. It also allows for a redefinition of the location of several internal organs. The execution of he Moby program generates a three-dimensional voxel-based phantom of a specified size, which was modified and used as input for Monte Carlo simulations of absorbed fractions and S-factors. The radiation transport was simulated both with the EGS4 system and the MCNPX 2.6a code. Calculations were done,for the radionuclides F-18, I-124, I-131, In-111, Lu-177, and Y-90. S-factors were calculated using in-house-developed IDL programs and compared with results from previously published models. Results: The comparison of S-factors obtained by the Moby model and mathematical phantoms showed that these, in many cases, were within the same range, whereas for some organs, they were underestimated in the mathematical phantoms. The results were closer to the more anatomically realistic phantom than to the mathematical phantoms, with some exceptions. When investing differences between MCNPX 2.6a and EGS4 using the Moby phantom, results indicated some differences in absorbed fractions for electrons. This reason may be owing to differences in the codes regarding the theory for which electron transport are simulated. Conclusions: It is possible to calculate S-factors that are specific for small animals, such as mice. The Moby phantom is useful as a dosimetry model because it is anatomically realistic, but still very flexible, with 35 accurately segmented regions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MCNPX, mouse phantom, small animal dosimetry, Moby, S factors, absorbed fractions, Monte Carlo
in
Cancer Biotherapy & Radiopharmaceuticals
volume
22
issue
3
pages
438 - 442
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000248040500017
  • scopus:34447509702
ISSN
1557-8852
DOI
10.1089/cbr.2006.320
language
English
LU publication?
yes
id
2cd57c82-b94d-4474-ad93-35d4bb73b772 (old id 645910)
date added to LUP
2007-12-12 13:05:30
date last changed
2017-06-04 04:18:04
@article{2cd57c82-b94d-4474-ad93-35d4bb73b772,
  abstract     = {Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phantom, as compared to previously mathematically described phantoms, based mainly on ellipsoids and cylinders. The difference in results from the two Monte Carlo codes, EGS4 and MCNPX 2.6a, was also evaluated. Methods: An anatomical correct mouse phantom (Moby) was developed by Segars et al. for the evaluation and optimization of the in vivo imaging of mice. The Moby phantom is based on surfaces, which allows for an easy and flexible definition of organ sizes. It includes respiratory movements and a beating heart. It also allows for a redefinition of the location of several internal organs. The execution of he Moby program generates a three-dimensional voxel-based phantom of a specified size, which was modified and used as input for Monte Carlo simulations of absorbed fractions and S-factors. The radiation transport was simulated both with the EGS4 system and the MCNPX 2.6a code. Calculations were done,for the radionuclides F-18, I-124, I-131, In-111, Lu-177, and Y-90. S-factors were calculated using in-house-developed IDL programs and compared with results from previously published models. Results: The comparison of S-factors obtained by the Moby model and mathematical phantoms showed that these, in many cases, were within the same range, whereas for some organs, they were underestimated in the mathematical phantoms. The results were closer to the more anatomically realistic phantom than to the mathematical phantoms, with some exceptions. When investing differences between MCNPX 2.6a and EGS4 using the Moby phantom, results indicated some differences in absorbed fractions for electrons. This reason may be owing to differences in the codes regarding the theory for which electron transport are simulated. Conclusions: It is possible to calculate S-factors that are specific for small animals, such as mice. The Moby phantom is useful as a dosimetry model because it is anatomically realistic, but still very flexible, with 35 accurately segmented regions.},
  author       = {Larsson, Erik and Strand, Sven-Erik and Ljungberg, Michael and Jönsson, Bo-Anders},
  issn         = {1557-8852},
  keyword      = {MCNPX,mouse phantom,small animal dosimetry,Moby,S factors,absorbed fractions,Monte Carlo},
  language     = {eng},
  number       = {3},
  pages        = {438--442},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Cancer Biotherapy & Radiopharmaceuticals},
  title        = {Mouse S-factors based on monte carlo simulations in the anatomical realistic Moby phantom for internal dosimetry},
  url          = {http://dx.doi.org/10.1089/cbr.2006.320},
  volume       = {22},
  year         = {2007},
}