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Autoimmune hepatitis among fertile women: Strategies during pregnancy and breastfeeding?

Werner, Marten; Bjornsson, Einar; Prytz, Hanne LU ; Lindgren, Stefan LU ; Almer, Sven; Broome, Ulrika; Wallerstedt, Sven; Sandberg-Gertzen, Hanna; Hultcrantz, Rolf and Sangfeldt, Per, et al. (2007) In Scandinavian Journal of Gastroenterology 42(8). p.986-991
Abstract
Objective. In published studies there is a lack of data about the risks, management and how women with autoimmune hepatitis (AIH) decide on and are advised about pregnancy. The aim of this study was to investigate how women with AIH consider pregnancies, are advised and pharmacologically treated, as well as the outcome. Material and methods. A questionnaire was mailed to 128 women with AIH diagnosed during their fertile period and data from the Swedish National Birth Register was also used for matched controls. Results. There was an 83% response rate to the questionnaires. Sixty-three pregnancies were reported by 35 women. 48% did not consult their doctors before getting pregnant. More than half of the women reduced or stopped the immune... (More)
Objective. In published studies there is a lack of data about the risks, management and how women with autoimmune hepatitis (AIH) decide on and are advised about pregnancy. The aim of this study was to investigate how women with AIH consider pregnancies, are advised and pharmacologically treated, as well as the outcome. Material and methods. A questionnaire was mailed to 128 women with AIH diagnosed during their fertile period and data from the Swedish National Birth Register was also used for matched controls. Results. There was an 83% response rate to the questionnaires. Sixty-three pregnancies were reported by 35 women. 48% did not consult their doctors before getting pregnant. More than half of the women reduced or stopped the immune suppression during pregnancy or breastfeeding. Some women were advised to abstain from pregnancy or even to have an abortion. Caesarean sections were performed more frequently in the AIH group (16% compared with 6.5% in the control group p < 0.01). There were no significant differences in the number of stillborn infants or infants with malformations. However, 30% of the patients experienced flare-up after delivery. Conclusions. In general, the outcome of pregnancy in women with AIH seems to be good. Current pharmacological treatment appears to be safe, including azathioprine during pregnancy and lactation. After delivery an active preparedness to increase pharmacotherapy should be considered. (Less)
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Contribution to journal
publication status
published
subject
keywords
outcome, autoimmune hepatitis, breastfeeding, pregnancy, pharmacotherapy
in
Scandinavian Journal of Gastroenterology
volume
42
issue
8
pages
986 - 991
publisher
Taylor & Francis
external identifiers
  • wos:000247778700013
  • scopus:34447125753
ISSN
1502-7708
DOI
10.1080/00365520601155266
language
English
LU publication?
yes
id
b27d7b6f-3b02-4bac-a6c7-c45d661ebd71 (old id 646116)
date added to LUP
2007-12-19 15:48:11
date last changed
2017-08-27 05:39:09
@article{b27d7b6f-3b02-4bac-a6c7-c45d661ebd71,
  abstract     = {Objective. In published studies there is a lack of data about the risks, management and how women with autoimmune hepatitis (AIH) decide on and are advised about pregnancy. The aim of this study was to investigate how women with AIH consider pregnancies, are advised and pharmacologically treated, as well as the outcome. Material and methods. A questionnaire was mailed to 128 women with AIH diagnosed during their fertile period and data from the Swedish National Birth Register was also used for matched controls. Results. There was an 83% response rate to the questionnaires. Sixty-three pregnancies were reported by 35 women. 48% did not consult their doctors before getting pregnant. More than half of the women reduced or stopped the immune suppression during pregnancy or breastfeeding. Some women were advised to abstain from pregnancy or even to have an abortion. Caesarean sections were performed more frequently in the AIH group (16% compared with 6.5% in the control group p &lt; 0.01). There were no significant differences in the number of stillborn infants or infants with malformations. However, 30% of the patients experienced flare-up after delivery. Conclusions. In general, the outcome of pregnancy in women with AIH seems to be good. Current pharmacological treatment appears to be safe, including azathioprine during pregnancy and lactation. After delivery an active preparedness to increase pharmacotherapy should be considered.},
  author       = {Werner, Marten and Bjornsson, Einar and Prytz, Hanne and Lindgren, Stefan and Almer, Sven and Broome, Ulrika and Wallerstedt, Sven and Sandberg-Gertzen, Hanna and Hultcrantz, Rolf and Sangfeldt, Per and Nilsson, Jenny and Danielsson, Ake},
  issn         = {1502-7708},
  keyword      = {outcome,autoimmune hepatitis,breastfeeding,pregnancy,pharmacotherapy},
  language     = {eng},
  number       = {8},
  pages        = {986--991},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Autoimmune hepatitis among fertile women: Strategies during pregnancy and breastfeeding?},
  url          = {http://dx.doi.org/10.1080/00365520601155266},
  volume       = {42},
  year         = {2007},
}