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Determinants of lung function and airway hyperresponsiveness in asthmatic children

Bisgaard, H.; Pedersen, S.; Anhoj, J.; Agertoft, L.; Hedlin, G.; Gulsvik, A.; Bjermer, Leif LU ; Carlsen, K. H.; Nordvall, L. and Lundack, B., et al. (2007) In Respiratory Medicine 101(7). p.1477-1482
Abstract
Background: Asthma patients exhibit an increased rate of loss of lung function. Determinants to such decline are largely unknown and the modifying effect of steroid therapy is disputed. This cross-sectional study aimed to elucidate factors contributing to such decline and the possible modifying effect of steroid treatment. Methods: We analyzed determinants of lung function and airway hyperresponsiveness (AHR) in a Scandinavian study of 2390 subjects from 550 families. Families were selected for the presence of two or more asthmatic children as part of a genetic study, Scandinavian Asthma Genetic Study (SAGA). Results: The primary analysis studied the association between the lung function and delay of inhaled corticosteroids (ICS) after... (More)
Background: Asthma patients exhibit an increased rate of loss of lung function. Determinants to such decline are largely unknown and the modifying effect of steroid therapy is disputed. This cross-sectional study aimed to elucidate factors contributing to such decline and the possible modifying effect of steroid treatment. Methods: We analyzed determinants of lung function and airway hyperresponsiveness (AHR) in a Scandinavian study of 2390 subjects from 550 families. Families were selected for the presence of two or more asthmatic children as part of a genetic study, Scandinavian Asthma Genetic Study (SAGA). Results: The primary analysis studied the association between the lung function and delay of inhaled corticosteroids (ICS) after asthma diagnosis among asthmatic children and young adults with a history of regular ICS treatment (N = 919). FEV1 percent predicted (FEV1% pred) was 0.25% lower per year of delay from diagnosis until treatment (p = 0.039). This association was significantly greater in allergy skin prick test negative children. There was no significant influence of gender, age at asthma onset, or smoking. In secondary analysis of the whole population of 2390 asthmatics and non-asthmatics, FEV1% pred was inversely related to having asthmatic siblings (-7.9%; p<0.0001), asthma diagnosis (-2.7%; p = 0.0007), smoking (-3.5%; p = 0.0027), and positive allergy skin prick test (-0.47% per test; p = 0.012), white positively related to being of female gender (1.8%; p = 0.0029). Risk of AHR was higher by having asthmatic siblings (OR 2.7; p<0.0001), being of female gender (OR 2.0; p<0.0001), and having asthma (OR 2.0; P<0.0001). Conclusions: These data suggest that Lung function is lower in asthmatics with delayed introduction of ICS therapy, smoking, and positive allergy skin prick test. Lung function is Lower and AHR higher in female asthmatics and subjects with asthmatic siblings or established asthma. (C) 2007 Elsevier Ltd. All rights reserved. (Less)
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publication status
published
subject
keywords
airway hyperresponsiveness, steroid, FEV1, asthma
in
Respiratory Medicine
volume
101
issue
7
pages
1477 - 1482
publisher
Elsevier
external identifiers
  • wos:000247765900016
  • scopus:34249823082
ISSN
1532-3064
DOI
10.1016/j.rmed.2007.01.013
language
English
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yes
id
6a7f0412-7132-4109-9096-c6db21a1b982 (old id 646142)
date added to LUP
2007-12-10 11:59:34
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2017-01-01 06:47:16
@article{6a7f0412-7132-4109-9096-c6db21a1b982,
  abstract     = {Background: Asthma patients exhibit an increased rate of loss of lung function. Determinants to such decline are largely unknown and the modifying effect of steroid therapy is disputed. This cross-sectional study aimed to elucidate factors contributing to such decline and the possible modifying effect of steroid treatment. Methods: We analyzed determinants of lung function and airway hyperresponsiveness (AHR) in a Scandinavian study of 2390 subjects from 550 families. Families were selected for the presence of two or more asthmatic children as part of a genetic study, Scandinavian Asthma Genetic Study (SAGA). Results: The primary analysis studied the association between the lung function and delay of inhaled corticosteroids (ICS) after asthma diagnosis among asthmatic children and young adults with a history of regular ICS treatment (N = 919). FEV1 percent predicted (FEV1% pred) was 0.25% lower per year of delay from diagnosis until treatment (p = 0.039). This association was significantly greater in allergy skin prick test negative children. There was no significant influence of gender, age at asthma onset, or smoking. In secondary analysis of the whole population of 2390 asthmatics and non-asthmatics, FEV1% pred was inversely related to having asthmatic siblings (-7.9%; p&lt;0.0001), asthma diagnosis (-2.7%; p = 0.0007), smoking (-3.5%; p = 0.0027), and positive allergy skin prick test (-0.47% per test; p = 0.012), white positively related to being of female gender (1.8%; p = 0.0029). Risk of AHR was higher by having asthmatic siblings (OR 2.7; p&lt;0.0001), being of female gender (OR 2.0; p&lt;0.0001), and having asthma (OR 2.0; P&lt;0.0001). Conclusions: These data suggest that Lung function is lower in asthmatics with delayed introduction of ICS therapy, smoking, and positive allergy skin prick test. Lung function is Lower and AHR higher in female asthmatics and subjects with asthmatic siblings or established asthma. (C) 2007 Elsevier Ltd. All rights reserved.},
  author       = {Bisgaard, H. and Pedersen, S. and Anhoj, J. and Agertoft, L. and Hedlin, G. and Gulsvik, A. and Bjermer, Leif and Carlsen, K. H. and Nordvall, L. and Lundack, B. and Wennergren, G. and Werner, S. and Bonnelykke, K. and Weiss, S. T.},
  issn         = {1532-3064},
  keyword      = {airway hyperresponsiveness,steroid,FEV1,asthma},
  language     = {eng},
  number       = {7},
  pages        = {1477--1482},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Determinants of lung function and airway hyperresponsiveness in asthmatic children},
  url          = {http://dx.doi.org/10.1016/j.rmed.2007.01.013},
  volume       = {101},
  year         = {2007},
}