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Increased long-term mortality in patients less than 55 years old who have undergone knee replacement for osteoarthritis - Results from the Swedish knee arthroplasty register

Robertsson, Otto LU ; Stefansdottir, Anna LU ; Lidgren, Lars LU and Ranstam, T. (2007) In Journal of Bone and Joint Surgery 89B(5). p.599-603
Abstract
Patients with osteoarthritis undergoing knee replacement have been reported to have an overall reduced mortality compared with that of the general population. This has been attributed to the selection of healthier patients for surgery. However, previous studies have had a maximum follow-up time of ten years. We have used information from the Swedish Knee Arthroplasty Register to study the mortality of a large national series of patients with total knee replacement for up to 28 years after surgery and compared their mortality with that of the normal population. In addition, for a subgroup of patients operated on between 1980 and 2002 we analysed their registered causes of death to determine if they differed from those expected. We found a... (More)
Patients with osteoarthritis undergoing knee replacement have been reported to have an overall reduced mortality compared with that of the general population. This has been attributed to the selection of healthier patients for surgery. However, previous studies have had a maximum follow-up time of ten years. We have used information from the Swedish Knee Arthroplasty Register to study the mortality of a large national series of patients with total knee replacement for up to 28 years after surgery and compared their mortality with that of the normal population. In addition, for a subgroup of patients operated on between 1980 and 2002 we analysed their registered causes of death to determine if they differed from those expected. We found a reduced overall mortality during the first 12 post-operative years after which it increased and became significantly higher than that of the general population. Age-specific analysis indicated an inverse correlation between age and mortality, where the younger the patients were, the higher their mortality. The shift at 12 years was caused by a relative over-representation of younger patients with a longer follow-up. Analysis of specific causes of death showed a higher mortality for cardiovascular, gastrointestinal and urogenital diseases. The observation that early onset of osteoarthritis of the knee which has been treated by total knee replacement is linked to an increased mortality should be a reason for increased general awareness of health problems in these patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Joint Surgery
volume
89B
issue
5
pages
599 - 603
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • wos:000247679600008
  • scopus:34250740003
ISSN
2044-5377
DOI
10.1302/0301-620X.89B5.18355
language
English
LU publication?
yes
id
95878b43-8203-45f5-96e9-58550e1012ae (old id 646426)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=%2017540743dopt=Abstract
date added to LUP
2007-12-14 12:14:22
date last changed
2017-11-05 03:34:23
@article{95878b43-8203-45f5-96e9-58550e1012ae,
  abstract     = {Patients with osteoarthritis undergoing knee replacement have been reported to have an overall reduced mortality compared with that of the general population. This has been attributed to the selection of healthier patients for surgery. However, previous studies have had a maximum follow-up time of ten years. We have used information from the Swedish Knee Arthroplasty Register to study the mortality of a large national series of patients with total knee replacement for up to 28 years after surgery and compared their mortality with that of the normal population. In addition, for a subgroup of patients operated on between 1980 and 2002 we analysed their registered causes of death to determine if they differed from those expected. We found a reduced overall mortality during the first 12 post-operative years after which it increased and became significantly higher than that of the general population. Age-specific analysis indicated an inverse correlation between age and mortality, where the younger the patients were, the higher their mortality. The shift at 12 years was caused by a relative over-representation of younger patients with a longer follow-up. Analysis of specific causes of death showed a higher mortality for cardiovascular, gastrointestinal and urogenital diseases. The observation that early onset of osteoarthritis of the knee which has been treated by total knee replacement is linked to an increased mortality should be a reason for increased general awareness of health problems in these patients.},
  author       = {Robertsson, Otto and Stefansdottir, Anna and Lidgren, Lars and Ranstam, T.},
  issn         = {2044-5377},
  language     = {eng},
  number       = {5},
  pages        = {599--603},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {Journal of Bone and Joint Surgery},
  title        = {Increased long-term mortality in patients less than 55 years old who have undergone knee replacement for osteoarthritis - Results from the Swedish knee arthroplasty register},
  url          = {http://dx.doi.org/10.1302/0301-620X.89B5.18355},
  volume       = {89B},
  year         = {2007},
}