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RIFM fragrance ingredient safety assessment, ethyl 4-pentenoate, CAS Registry Number 1968-40-7

Api, A. M. ; Belsito, D. ; Biserta, S. ; Botelho, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Cancellieri, M. A. ; Dagli, M. L. and Date, M. , et al. (2021) In Food and Chemical Toxicology 149.
Abstract
The existing information supports the use of this material as described in this safety assessment.Ethyl
4-pentenoate was evaluated for genotoxicity, repeated dose toxicity,
reproductive toxicity, local respiratory toxicity,
phototoxicity/photoallergenicity, skin sensitization, and environmental
safety. Data from read-across analog methyl undec-10-enoate (CAS #
111-81-9) show that ethyl 4-pentenoate is not expected to be genotoxic.
The repeated dose, reproductive, and local respiratory toxicity
endpoints were evaluated using the threshold of toxicological concern
(TTC) for a Cramer Class I material, and the exposure to ethyl
4-pentenoate is below the TTC (0.03 mg/kg/day, 0.03... (More)
The existing information supports the use of this material as described in this safety assessment.Ethyl
4-pentenoate was evaluated for genotoxicity, repeated dose toxicity,
reproductive toxicity, local respiratory toxicity,
phototoxicity/photoallergenicity, skin sensitization, and environmental
safety. Data from read-across analog methyl undec-10-enoate (CAS #
111-81-9) show that ethyl 4-pentenoate is not expected to be genotoxic.
The repeated dose, reproductive, and local respiratory toxicity
endpoints were evaluated using the threshold of toxicological concern
(TTC) for a Cramer Class I material, and the exposure to ethyl
4-pentenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and
1.4 mg/day, respectively). The skin sensitization endpoint was completed
using the dermal sensitization threshold (DST) for non-reactive
materials (900 μg/cm2); exposure is below the DST. The
phototoxicity/photoallergenicity endpoints were evaluated based on
ultraviolet (UV) spectra; ethyl 4-pentenoate is not expected to be
phototoxic/photoallergenic. The environmental endpoints were evaluated;
ethyl 4-pentenoate was found not to be persistent, bioaccumulative, and
toxic (PBT) as per the International Fragrance Association (IFRA)
Environmental Standards, and its risk quotients, based on its current
volume of use in Europe and North America (i.e., Predicted Environmental
Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Food and Chemical Toxicology
volume
149
article number
112048
publisher
Elsevier
external identifiers
  • pmid:33571608
  • scopus:85100807981
ISSN
0278-6915
DOI
10.1016/j.fct.2021.112048
language
English
LU publication?
no
id
64749d43-1bf0-45f5-9c71-2f658f06b4c6
date added to LUP
2021-03-05 07:45:45
date last changed
2024-05-30 07:40:45
@article{64749d43-1bf0-45f5-9c71-2f658f06b4c6,
  abstract     = {{<strong>The existing information supports the use of this material as described in this safety assessment.</strong>Ethyl<br>
 4-pentenoate was evaluated for genotoxicity, repeated dose toxicity, <br>
reproductive toxicity, local respiratory toxicity, <br>
phototoxicity/photoallergenicity, skin sensitization, and environmental <br>
safety. Data from read-across analog methyl undec-10-enoate (CAS # <br>
111-81-9) show that ethyl 4-pentenoate is not expected to be genotoxic. <br>
The repeated dose, reproductive, and local respiratory toxicity <br>
endpoints were evaluated using the threshold of toxicological concern <br>
(TTC) for a Cramer Class I material, and the exposure to ethyl <br>
4-pentenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and <br>
1.4 mg/day, respectively). The skin sensitization endpoint was completed<br>
 using the dermal sensitization threshold (DST) for non-reactive <br>
materials (900 μg/cm<sup>2</sup>); exposure is below the DST. The <br>
phototoxicity/photoallergenicity endpoints were evaluated based on <br>
ultraviolet (UV) spectra; ethyl 4-pentenoate is not expected to be <br>
phototoxic/photoallergenic. The environmental endpoints were evaluated; <br>
ethyl 4-pentenoate was found not to be persistent, bioaccumulative, and <br>
toxic (PBT) as per the International Fragrance Association (IFRA) <br>
Environmental Standards, and its risk quotients, based on its current <br>
volume of use in Europe and North America (i.e., Predicted Environmental<br>
 Concentration/Predicted No Effect Concentration [PEC/PNEC]), are &lt;1.}},
  author       = {{Api, A. M. and Belsito, D. and Biserta, S. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Cancellieri, M. A. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Gadhia, S. and Jones, L. and Joshi, K. and Kumar, M. and Lapczynski, A. and Lavelle, M. and Lee, I. and Liebler, D. C. and Moustakas, H. and Na, M. and Penning, T. M. and Ritacco, G. and Romine, J. and Sadekar, N. and Schultz, T. W. and Selechnik, D. and Siddiqi, F. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y.}},
  issn         = {{0278-6915}},
  language     = {{eng}},
  month        = {{01}},
  publisher    = {{Elsevier}},
  series       = {{Food and Chemical Toxicology}},
  title        = {{RIFM fragrance ingredient safety assessment, ethyl 4-pentenoate, CAS Registry Number 1968-40-7}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2021.112048}},
  doi          = {{10.1016/j.fct.2021.112048}},
  volume       = {{149}},
  year         = {{2021}},
}