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Hyperglycernia down-regulates apolipoprotein M expression in vivo and in vitro

Zhang, Xiaoying; Jiang, Bo; Luo, Guanghua; Nilsson-Ehle, Peter LU and Xu, Ning LU (2007) In Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1771(7). p.879-882
Abstract
Diabetes is associated with low concentrations of apoM in plasma. In db/db mice, ob/ob mice as well as in the alloxan-induced diabetic mouse, the low apoM levels are paralleled by decreased expression of the apoM gene. In the latter model, insulin substitution tended to reverse the low apoM expression. It is not known whether the impairment in apoM expression can be ascribed to hyperglycemia, insulin deficiency or insulin resistance. In the present study, we investigated apoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion. As expected, serum insulin concentrations rose moderately during the infusions. Serum apoM concentrations and hepatic apoM mRNA levels were significantly reduced in the hyperglycemic... (More)
Diabetes is associated with low concentrations of apoM in plasma. In db/db mice, ob/ob mice as well as in the alloxan-induced diabetic mouse, the low apoM levels are paralleled by decreased expression of the apoM gene. In the latter model, insulin substitution tended to reverse the low apoM expression. It is not known whether the impairment in apoM expression can be ascribed to hyperglycemia, insulin deficiency or insulin resistance. In the present study, we investigated apoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion. As expected, serum insulin concentrations rose moderately during the infusions. Serum apoM concentrations and hepatic apoM mRNA levels were significantly reduced in the hyperglycemic rats, indicating that the low expression of apoM in these diabetic models can be ascribed to hyperglycemia rather than to insulin deficiency or insulin resistance. However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
apolipoprotein M, hyperglycemia, insulin, diabetes, glucose
in
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
volume
1771
issue
7
pages
879 - 882
publisher
Elsevier
external identifiers
  • wos:000247715200010
  • scopus:34249984497
ISSN
1388-1981
DOI
10.1016/j.bbalip.2007.04.020
language
English
LU publication?
yes
id
2cc61ec5-3096-40c3-8da1-308dcfdf3145 (old id 647569)
date added to LUP
2007-12-19 10:06:00
date last changed
2017-01-22 04:06:56
@article{2cc61ec5-3096-40c3-8da1-308dcfdf3145,
  abstract     = {Diabetes is associated with low concentrations of apoM in plasma. In db/db mice, ob/ob mice as well as in the alloxan-induced diabetic mouse, the low apoM levels are paralleled by decreased expression of the apoM gene. In the latter model, insulin substitution tended to reverse the low apoM expression. It is not known whether the impairment in apoM expression can be ascribed to hyperglycemia, insulin deficiency or insulin resistance. In the present study, we investigated apoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion. As expected, serum insulin concentrations rose moderately during the infusions. Serum apoM concentrations and hepatic apoM mRNA levels were significantly reduced in the hyperglycemic rats, indicating that the low expression of apoM in these diabetic models can be ascribed to hyperglycemia rather than to insulin deficiency or insulin resistance. However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly.},
  author       = {Zhang, Xiaoying and Jiang, Bo and Luo, Guanghua and Nilsson-Ehle, Peter and Xu, Ning},
  issn         = {1388-1981},
  keyword      = {apolipoprotein M,hyperglycemia,insulin,diabetes,glucose},
  language     = {eng},
  number       = {7},
  pages        = {879--882},
  publisher    = {Elsevier},
  series       = {Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids},
  title        = {Hyperglycernia down-regulates apolipoprotein M expression in vivo and in vitro},
  url          = {http://dx.doi.org/10.1016/j.bbalip.2007.04.020},
  volume       = {1771},
  year         = {2007},
}