Hyperglycernia down-regulates apolipoprotein M expression in vivo and in vitro
(2007) In Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1771(7). p.879-882- Abstract
- Diabetes is associated with low concentrations of apoM in plasma. In db/db mice, ob/ob mice as well as in the alloxan-induced diabetic mouse, the low apoM levels are paralleled by decreased expression of the apoM gene. In the latter model, insulin substitution tended to reverse the low apoM expression. It is not known whether the impairment in apoM expression can be ascribed to hyperglycemia, insulin deficiency or insulin resistance. In the present study, we investigated apoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion. As expected, serum insulin concentrations rose moderately during the infusions. Serum apoM concentrations and hepatic apoM mRNA levels were significantly reduced in the hyperglycemic... (More)
- Diabetes is associated with low concentrations of apoM in plasma. In db/db mice, ob/ob mice as well as in the alloxan-induced diabetic mouse, the low apoM levels are paralleled by decreased expression of the apoM gene. In the latter model, insulin substitution tended to reverse the low apoM expression. It is not known whether the impairment in apoM expression can be ascribed to hyperglycemia, insulin deficiency or insulin resistance. In the present study, we investigated apoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion. As expected, serum insulin concentrations rose moderately during the infusions. Serum apoM concentrations and hepatic apoM mRNA levels were significantly reduced in the hyperglycemic rats, indicating that the low expression of apoM in these diabetic models can be ascribed to hyperglycemia rather than to insulin deficiency or insulin resistance. However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/647569
- author
- Zhang, Xiaoying ; Jiang, Bo ; Luo, Guanghua ; Nilsson-Ehle, Peter LU and Xu, Ning LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- apolipoprotein M, hyperglycemia, insulin, diabetes, glucose
- in
- Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
- volume
- 1771
- issue
- 7
- pages
- 879 - 882
- publisher
- Elsevier
- external identifiers
-
- wos:000247715200010
- scopus:34249984497
- ISSN
- 1388-1981
- DOI
- 10.1016/j.bbalip.2007.04.020
- language
- English
- LU publication?
- yes
- id
- 2cc61ec5-3096-40c3-8da1-308dcfdf3145 (old id 647569)
- date added to LUP
- 2016-04-01 16:24:59
- date last changed
- 2022-04-15 04:23:16
@article{2cc61ec5-3096-40c3-8da1-308dcfdf3145, abstract = {{Diabetes is associated with low concentrations of apoM in plasma. In db/db mice, ob/ob mice as well as in the alloxan-induced diabetic mouse, the low apoM levels are paralleled by decreased expression of the apoM gene. In the latter model, insulin substitution tended to reverse the low apoM expression. It is not known whether the impairment in apoM expression can be ascribed to hyperglycemia, insulin deficiency or insulin resistance. In the present study, we investigated apoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion. As expected, serum insulin concentrations rose moderately during the infusions. Serum apoM concentrations and hepatic apoM mRNA levels were significantly reduced in the hyperglycemic rats, indicating that the low expression of apoM in these diabetic models can be ascribed to hyperglycemia rather than to insulin deficiency or insulin resistance. However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly.}}, author = {{Zhang, Xiaoying and Jiang, Bo and Luo, Guanghua and Nilsson-Ehle, Peter and Xu, Ning}}, issn = {{1388-1981}}, keywords = {{apolipoprotein M; hyperglycemia; insulin; diabetes; glucose}}, language = {{eng}}, number = {{7}}, pages = {{879--882}}, publisher = {{Elsevier}}, series = {{Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids}}, title = {{Hyperglycernia down-regulates apolipoprotein M expression in vivo and in vitro}}, url = {{http://dx.doi.org/10.1016/j.bbalip.2007.04.020}}, doi = {{10.1016/j.bbalip.2007.04.020}}, volume = {{1771}}, year = {{2007}}, }