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Association between age and epididymal and accessory sex gland function and their relation to sperm motility

Elzanaty, Saad LU (2007) In Archives of Andrology 53(3). p.149-156
Abstract
Increased male age has been associated with significant reduction in pregnancy rates. This study investigated the association between age, the function of epididymal and accessory sex glands, and their relation to sperm motility. Ejaculates from 498 men assessed for infertility were analysed according to WHO [1999] guidelines. Seminal markers of epididymal (neutral alpha-glucosidase (NAG)), prostatic (prostate-specific antigen (PSA) and zinc), and seminal vesicle function (fructose) were measured. Four groups according to age were defined: G(21-30) (21-30 years), G(31-40) (31-40 years), G(41-50) (41-50 years), and G(> 50) (51-66 years). Percentage progressive motility was significantly lower in G(> 50) compared with G21-30. NAG, PSA,... (More)
Increased male age has been associated with significant reduction in pregnancy rates. This study investigated the association between age, the function of epididymal and accessory sex glands, and their relation to sperm motility. Ejaculates from 498 men assessed for infertility were analysed according to WHO [1999] guidelines. Seminal markers of epididymal (neutral alpha-glucosidase (NAG)), prostatic (prostate-specific antigen (PSA) and zinc), and seminal vesicle function (fructose) were measured. Four groups according to age were defined: G(21-30) (21-30 years), G(31-40) (31-40 years), G(41-50) (41-50 years), and G(> 50) (51-66 years). Percentage progressive motility was significantly lower in G(> 50) compared with G21-30. NAG, PSA, zinc, and fructose were significantly lower in G(> 50) compared with G21-30. In a multiple regression analysis model, NAG and PSA showed positive significant association with percentage progressive motility. The opposite trend was found regarding zinc. No association between fructose and percentage progressive motility was shown. In this cross-sectional study, declined sperm motility observed in men over 50 years of age might be due to age-dependent changes in epididymal and accessory sex gland function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epididymis, accessory sex gland, sperm motility, male age
in
Archives of Andrology
volume
53
issue
3
pages
149 - 156
publisher
Taylor & Francis
external identifiers
  • wos:000247731300005
ISSN
0148-5016
DOI
10.1080/01485010701225667
language
English
LU publication?
yes
id
0f91259d-e03e-42d8-ac3f-a1746c12bd2e (old id 647590)
date added to LUP
2007-12-10 16:11:19
date last changed
2016-04-16 04:58:42
@article{0f91259d-e03e-42d8-ac3f-a1746c12bd2e,
  abstract     = {Increased male age has been associated with significant reduction in pregnancy rates. This study investigated the association between age, the function of epididymal and accessory sex glands, and their relation to sperm motility. Ejaculates from 498 men assessed for infertility were analysed according to WHO [1999] guidelines. Seminal markers of epididymal (neutral alpha-glucosidase (NAG)), prostatic (prostate-specific antigen (PSA) and zinc), and seminal vesicle function (fructose) were measured. Four groups according to age were defined: G(21-30) (21-30 years), G(31-40) (31-40 years), G(41-50) (41-50 years), and G(> 50) (51-66 years). Percentage progressive motility was significantly lower in G(> 50) compared with G21-30. NAG, PSA, zinc, and fructose were significantly lower in G(> 50) compared with G21-30. In a multiple regression analysis model, NAG and PSA showed positive significant association with percentage progressive motility. The opposite trend was found regarding zinc. No association between fructose and percentage progressive motility was shown. In this cross-sectional study, declined sperm motility observed in men over 50 years of age might be due to age-dependent changes in epididymal and accessory sex gland function.},
  author       = {Elzanaty, Saad},
  issn         = {0148-5016},
  keyword      = {epididymis,accessory sex gland,sperm motility,male age},
  language     = {eng},
  number       = {3},
  pages        = {149--156},
  publisher    = {Taylor & Francis},
  series       = {Archives of Andrology},
  title        = {Association between age and epididymal and accessory sex gland function and their relation to sperm motility},
  url          = {http://dx.doi.org/10.1080/01485010701225667},
  volume       = {53},
  year         = {2007},
}