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Dynamic assembly of molecularly imprinted polymer nanoparticles

Gong, Haiyue LU ; Hajizadeh, Solmaz LU ; Jiang, Lingdong LU ; Ma, Huiting and Ye, Lei LU (2018) In Journal of Colloid and Interface Science 509. p.463-471
Abstract

Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The... (More)

Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The imprinted polymer nanoparticles modified with boronic acid and cis-diol structures maintained high molecular binding specificity, and the nanoparticles could be induced to form dynamic particle aggregation that responded to pH variation and chemical stimuli. The possibility of modulating molecular binding and nanoparticle assembly in a mutually independent fashion can be exploited in a number of applications where repeated use of precious nanoparticles is needed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Boronic acid, Dynamic assembly, Molecular imprinting, Molecular recognition, Nanoparticles
in
Journal of Colloid and Interface Science
volume
509
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85029532399
ISSN
0021-9797
DOI
10.1016/j.jcis.2017.09.046
language
English
LU publication?
yes
id
6475e870-418a-4007-98e9-e78f093a5158
date added to LUP
2017-09-28 14:37:03
date last changed
2018-01-07 12:19:54
@article{6475e870-418a-4007-98e9-e78f093a5158,
  abstract     = {<p>Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The imprinted polymer nanoparticles modified with boronic acid and cis-diol structures maintained high molecular binding specificity, and the nanoparticles could be induced to form dynamic particle aggregation that responded to pH variation and chemical stimuli. The possibility of modulating molecular binding and nanoparticle assembly in a mutually independent fashion can be exploited in a number of applications where repeated use of precious nanoparticles is needed.</p>},
  author       = {Gong, Haiyue and Hajizadeh, Solmaz and Jiang, Lingdong and Ma, Huiting and Ye, Lei},
  issn         = {0021-9797},
  keyword      = {Boronic acid,Dynamic assembly,Molecular imprinting,Molecular recognition,Nanoparticles},
  language     = {eng},
  month        = {01},
  pages        = {463--471},
  publisher    = {Elsevier},
  series       = {Journal of Colloid and Interface Science},
  title        = {Dynamic assembly of molecularly imprinted polymer nanoparticles},
  url          = {http://dx.doi.org/10.1016/j.jcis.2017.09.046},
  volume       = {509},
  year         = {2018},
}