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Selective removal of 17 beta-estradiol at trace concentration using a molecularly imprinted polymer

Le Noir, Mathieu LU ; Lepeuple, Anne-Sophie; Guieysse, Benoit LU and Mattiasson, Bo LU (2007) In Water Research 41(12). p.2825-2831
Abstract
A molecularly imprinted polymer (MIP) was synthesized with 17 beta-estradiol (E2) as template. It was then capable to recover this compound by 100 +/- 0.6% from a 2 mu g/L aqueous solution. By comparison, E2 recoveries of 77 +/- 5.2%, 87.1 +/- 2.3% and 19.1 +/- 7.8%, were achieved using a non-imprinted polymer (NIP) synthesized under the same conditions (but without template), a commercial C18 extraction phase and granular-activated carbon (GAC), respectively When fluoxetine hydrochloride and acenaphthene were added as interferences to the aqueous solution at 2 mu g/L each, E2 was recovered by 95.5 +/- 4.0% from the MIP, compared to 54.5 +/- 9.4%, 76.0 +/- 2% and 14.3 +/- 0.1% from the NIP, C18 and GAC phases, respectively Estrogenic... (More)
A molecularly imprinted polymer (MIP) was synthesized with 17 beta-estradiol (E2) as template. It was then capable to recover this compound by 100 +/- 0.6% from a 2 mu g/L aqueous solution. By comparison, E2 recoveries of 77 +/- 5.2%, 87.1 +/- 2.3% and 19.1 +/- 7.8%, were achieved using a non-imprinted polymer (NIP) synthesized under the same conditions (but without template), a commercial C18 extraction phase and granular-activated carbon (GAC), respectively When fluoxetine hydrochloride and acenaphthene were added as interferences to the aqueous solution at 2 mu g/L each, E2 was recovered by 95.5 +/- 4.0% from the MIP, compared to 54.5 +/- 9.4%, 76.0 +/- 2% and 14.3 +/- 0.1% from the NIP, C18 and GAC phases, respectively Estrogenic activity equivalent to the effect caused by 22.4ng E2/L was recorded in the MIP extract from a wastewater sample whereas no activity was detected in the NIP extract. This suggested the imprinted polymers removed estrogenic compounds. This study therefore demonstrates the potential of MIPs for the selective removal of endocrine-disrupting compounds. By using a synthetic analogue to natural hormone receptors, adsorption is based on the same property that makes the contaminants harmful. Biological treatment of enriched E2 was also demonstrated. (c) 2007 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecular imprinting, endocrine disrupter, estrogen, yeast estrogen screen, trace contaminant
in
Water Research
volume
41
issue
12
pages
2825 - 2831
publisher
Elsevier
external identifiers
  • wos:000247585800035
  • scopus:34249075738
ISSN
1879-2448
DOI
10.1016/j.watres.2007.03.023
language
English
LU publication?
yes
id
f033698c-690b-4571-80c8-a7c0287c696c (old id 647636)
date added to LUP
2007-12-12 13:30:57
date last changed
2017-01-22 04:05:56
@article{f033698c-690b-4571-80c8-a7c0287c696c,
  abstract     = {A molecularly imprinted polymer (MIP) was synthesized with 17 beta-estradiol (E2) as template. It was then capable to recover this compound by 100 +/- 0.6% from a 2 mu g/L aqueous solution. By comparison, E2 recoveries of 77 +/- 5.2%, 87.1 +/- 2.3% and 19.1 +/- 7.8%, were achieved using a non-imprinted polymer (NIP) synthesized under the same conditions (but without template), a commercial C18 extraction phase and granular-activated carbon (GAC), respectively When fluoxetine hydrochloride and acenaphthene were added as interferences to the aqueous solution at 2 mu g/L each, E2 was recovered by 95.5 +/- 4.0% from the MIP, compared to 54.5 +/- 9.4%, 76.0 +/- 2% and 14.3 +/- 0.1% from the NIP, C18 and GAC phases, respectively Estrogenic activity equivalent to the effect caused by 22.4ng E2/L was recorded in the MIP extract from a wastewater sample whereas no activity was detected in the NIP extract. This suggested the imprinted polymers removed estrogenic compounds. This study therefore demonstrates the potential of MIPs for the selective removal of endocrine-disrupting compounds. By using a synthetic analogue to natural hormone receptors, adsorption is based on the same property that makes the contaminants harmful. Biological treatment of enriched E2 was also demonstrated. (c) 2007 Elsevier Ltd. All rights reserved.},
  author       = {Le Noir, Mathieu and Lepeuple, Anne-Sophie and Guieysse, Benoit and Mattiasson, Bo},
  issn         = {1879-2448},
  keyword      = {molecular imprinting,endocrine disrupter,estrogen,yeast estrogen screen,trace contaminant},
  language     = {eng},
  number       = {12},
  pages        = {2825--2831},
  publisher    = {Elsevier},
  series       = {Water Research},
  title        = {Selective removal of 17 beta-estradiol at trace concentration using a molecularly imprinted polymer},
  url          = {http://dx.doi.org/10.1016/j.watres.2007.03.023},
  volume       = {41},
  year         = {2007},
}