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Molecularly imprinted polymer films for reflectometric interference spectroscopic sensors

Belmont, Anne-Sophie LU ; Jaeger, Stefanie; Knopp, Dietmar; Niessner, Reinhard; Gauglitz, Guenter and Haupt, Karsten (2007) In Biosensors & Bioelectronics 22(12). p.3267-3272
Abstract
Reflectometric interference spectroscopic measurements were performed on molecularly imprinted polymer (MIP) films with the herbicide atrazine as the template molecule. A conventional imprinting protocol was used relying on non-covalent interactions between the functional monomers and the template. The MIPs were deposited on glass transducers by two different methods: spin-coating followed by in situ polymerization of thin films of monomers containing a sacrificial polymeric porogen, and autoassembly of MIP nanoparticles with the aid of an associative linear polymer. Reproducible results were obtained upon measurements of atrazine solutions in toluene with both films. Atrazine concentrations as low as 1.7 pprn could be detected with the... (More)
Reflectometric interference spectroscopic measurements were performed on molecularly imprinted polymer (MIP) films with the herbicide atrazine as the template molecule. A conventional imprinting protocol was used relying on non-covalent interactions between the functional monomers and the template. The MIPs were deposited on glass transducers by two different methods: spin-coating followed by in situ polymerization of thin films of monomers containing a sacrificial polymeric porogen, and autoassembly of MIP nanoparticles with the aid of an associative linear polymer. Reproducible results were obtained upon measurements of atrazine solutions in toluene with both films. Atrazine concentrations as low as 1.7 pprn could be detected with the autoassembled particle film. No or very little analyte adsorption was observed onto non-imprinted control films made by spin-coating and by particle assembly, respectively. We believe that these MIP layers in combination with the general reflectrometric transduction scheme could be a versatile sensing tool for the detection of environmentally important and other analytes. (c) 2007 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecularly imprinted polymer, synthetic receptor, chemical sensor, reflectometric interference spectroscopy, thin film
in
Biosensors & Bioelectronics
volume
22
issue
12
pages
3267 - 3272
publisher
Elsevier
external identifiers
  • wos:000247555300074
  • scopus:34248586931
ISSN
1873-4235
DOI
10.1016/j.bios.2007.01.023
language
English
LU publication?
yes
id
526f1a8c-1894-4dc9-aec3-0b62f7a32a98 (old id 647871)
date added to LUP
2007-12-05 11:06:36
date last changed
2017-08-20 04:17:12
@article{526f1a8c-1894-4dc9-aec3-0b62f7a32a98,
  abstract     = {Reflectometric interference spectroscopic measurements were performed on molecularly imprinted polymer (MIP) films with the herbicide atrazine as the template molecule. A conventional imprinting protocol was used relying on non-covalent interactions between the functional monomers and the template. The MIPs were deposited on glass transducers by two different methods: spin-coating followed by in situ polymerization of thin films of monomers containing a sacrificial polymeric porogen, and autoassembly of MIP nanoparticles with the aid of an associative linear polymer. Reproducible results were obtained upon measurements of atrazine solutions in toluene with both films. Atrazine concentrations as low as 1.7 pprn could be detected with the autoassembled particle film. No or very little analyte adsorption was observed onto non-imprinted control films made by spin-coating and by particle assembly, respectively. We believe that these MIP layers in combination with the general reflectrometric transduction scheme could be a versatile sensing tool for the detection of environmentally important and other analytes. (c) 2007 Elsevier B.V. All rights reserved.},
  author       = {Belmont, Anne-Sophie and Jaeger, Stefanie and Knopp, Dietmar and Niessner, Reinhard and Gauglitz, Guenter and Haupt, Karsten},
  issn         = {1873-4235},
  keyword      = {molecularly imprinted polymer,synthetic receptor,chemical sensor,reflectometric interference spectroscopy,thin film},
  language     = {eng},
  number       = {12},
  pages        = {3267--3272},
  publisher    = {Elsevier},
  series       = {Biosensors & Bioelectronics},
  title        = {Molecularly imprinted polymer films for reflectometric interference spectroscopic sensors},
  url          = {http://dx.doi.org/10.1016/j.bios.2007.01.023},
  volume       = {22},
  year         = {2007},
}