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The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin

Pinheiro, T.; Pallon, Jan LU ; Alves, L. C.; Verissimo, A.; Filipe, P.; Silva, J. N. and Silva, R. (2007) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 260(1). p.119-123
Abstract
The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition,... (More)
The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
volume
260
issue
1
pages
119 - 123
publisher
Elsevier
external identifiers
  • wos:000248264900024
  • scopus:34249881862
ISSN
0168-583X
DOI
10.1016/j.nimb.2007.02.014
language
English
LU publication?
yes
id
3da7dc80-24f4-4172-b55c-7afd29e1cc4f (old id 647985)
date added to LUP
2007-12-19 14:11:37
date last changed
2017-09-10 04:38:58
@article{3da7dc80-24f4-4172-b55c-7afd29e1cc4f,
  abstract     = {The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved.},
  author       = {Pinheiro, T. and Pallon, Jan and Alves, L. C. and Verissimo, A. and Filipe, P. and Silva, J. N. and Silva, R.},
  issn         = {0168-583X},
  language     = {eng},
  number       = {1},
  pages        = {119--123},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms},
  title        = {The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin},
  url          = {http://dx.doi.org/10.1016/j.nimb.2007.02.014},
  volume       = {260},
  year         = {2007},
}