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On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

Lekki, J.; Stachura, Z.; Dabros, W.; Stachura, J.; Menzel, F.; Reinert, T.; Butz, T.; Pallon, Jan LU ; Gontier, E. and Ynsa, M. D., et al. (2007) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 260(1). p.174-177
Abstract
We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands. (c) 2007 Elsevier B.V. All rights reserved.
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publication status
published
subject
keywords
ion microprobe, skin penetration, titanium dioxide, nanoparticles, autoradiography
in
Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
volume
260
issue
1
pages
174 - 177
publisher
Elsevier
external identifiers
  • wos:000248264900034
  • scopus:34250027287
ISSN
0168-583X
DOI
10.1016/j.nimb.2007.02.021
language
English
LU publication?
yes
id
7b5b92ed-1eee-44a9-b956-4940938ab773 (old id 648004)
date added to LUP
2007-12-14 13:55:20
date last changed
2017-07-30 04:41:25
@article{7b5b92ed-1eee-44a9-b956-4940938ab773,
  abstract     = {We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands. (c) 2007 Elsevier B.V. All rights reserved.},
  author       = {Lekki, J. and Stachura, Z. and Dabros, W. and Stachura, J. and Menzel, F. and Reinert, T. and Butz, T. and Pallon, Jan and Gontier, E. and Ynsa, M. D. and Moretto, P. and Kertesz, Z. and Szikszai, Z. and Kiss, A. Z.},
  issn         = {0168-583X},
  keyword      = {ion microprobe,skin penetration,titanium dioxide,nanoparticles,autoradiography},
  language     = {eng},
  number       = {1},
  pages        = {174--177},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms},
  title        = {On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies},
  url          = {http://dx.doi.org/10.1016/j.nimb.2007.02.021},
  volume       = {260},
  year         = {2007},
}