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Delivering needle-free insulin using AERx (R) iDMS (Insulin Diabetes Management System) technology

Wollmer, Per LU ; Pieber, Thomas R.; Gall, Mari-Anne and Brunton, Stephen (2007) In Diabetes Technology & Therapeutics 9. p.57-64
Abstract
Background and Methods: Inhaled insulin has recently emerged as an alternative to subcutaneous insulin administration. One inhaled insulin device, AERx (R) (a registered trademark of Aradigm Corp., Hayward, CA, or its affiliates in the United States and other countries) insulin diabetes management system (iDMS) (Novo Nordisk A/S, Bagsvoerd, Denmark), uses a unique liquid human insulin strip to deliver an aerosol of insulin to the lungs. AERx iDMS enables 1-unit increment dosing, and the device ensures that the insulin dose is released at the optimal point of inhalation for delivery to the lungs. Results: Compared with subcutaneous human insulin, the pharmacokinetic and pharmacodynamic profile of inhaled insulin with AERx iDMS is similar,... (More)
Background and Methods: Inhaled insulin has recently emerged as an alternative to subcutaneous insulin administration. One inhaled insulin device, AERx (R) (a registered trademark of Aradigm Corp., Hayward, CA, or its affiliates in the United States and other countries) insulin diabetes management system (iDMS) (Novo Nordisk A/S, Bagsvoerd, Denmark), uses a unique liquid human insulin strip to deliver an aerosol of insulin to the lungs. AERx iDMS enables 1-unit increment dosing, and the device ensures that the insulin dose is released at the optimal point of inhalation for delivery to the lungs. Results: Compared with subcutaneous human insulin, the pharmacokinetic and pharmacodynamic profile of inhaled insulin with AERx iDMS is similar, but with a more rapid onset of action. Data from these pharmacokinetic studies have also demonstrated that inhaled insulin dosing with AERx iDMS is as consistent and reproducible as subcutaneous human insulin. Conclusions: In individuals with diabetes prandial inhaled insulin with AERx iDMS is as effective and well tolerated as subcutaneous prandial human insulin or insulin aspart in terms of glycemic control and overall hypoglycemia. No major safety concerns have been raised with respect to pulmonary function tests. Other clinical studies using AERx iDMS in special populations, such as smokers, people with asthma, or people suffering from upper respiratory tract infections, have provided important information regarding the use of inhaled insulin in these circumstances. Overall, pulmonary insulin delivery with the AERx iDMS device appears to be a promising safe and efficacious alternative to subcutaneous insulin injections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Technology & Therapeutics
volume
9
pages
57 - 64
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000247377500007
  • scopus:34250719693
ISSN
1520-9156
DOI
10.1089/dia.2007.0206
language
English
LU publication?
yes
id
bdaddedd-2f63-4a20-a13b-3bb6487785b2 (old id 648525)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17563305&dopt=Abstract
date added to LUP
2008-01-03 11:08:22
date last changed
2017-01-01 05:01:37
@article{bdaddedd-2f63-4a20-a13b-3bb6487785b2,
  abstract     = {Background and Methods: Inhaled insulin has recently emerged as an alternative to subcutaneous insulin administration. One inhaled insulin device, AERx (R) (a registered trademark of Aradigm Corp., Hayward, CA, or its affiliates in the United States and other countries) insulin diabetes management system (iDMS) (Novo Nordisk A/S, Bagsvoerd, Denmark), uses a unique liquid human insulin strip to deliver an aerosol of insulin to the lungs. AERx iDMS enables 1-unit increment dosing, and the device ensures that the insulin dose is released at the optimal point of inhalation for delivery to the lungs. Results: Compared with subcutaneous human insulin, the pharmacokinetic and pharmacodynamic profile of inhaled insulin with AERx iDMS is similar, but with a more rapid onset of action. Data from these pharmacokinetic studies have also demonstrated that inhaled insulin dosing with AERx iDMS is as consistent and reproducible as subcutaneous human insulin. Conclusions: In individuals with diabetes prandial inhaled insulin with AERx iDMS is as effective and well tolerated as subcutaneous prandial human insulin or insulin aspart in terms of glycemic control and overall hypoglycemia. No major safety concerns have been raised with respect to pulmonary function tests. Other clinical studies using AERx iDMS in special populations, such as smokers, people with asthma, or people suffering from upper respiratory tract infections, have provided important information regarding the use of inhaled insulin in these circumstances. Overall, pulmonary insulin delivery with the AERx iDMS device appears to be a promising safe and efficacious alternative to subcutaneous insulin injections.},
  author       = {Wollmer, Per and Pieber, Thomas R. and Gall, Mari-Anne and Brunton, Stephen},
  issn         = {1520-9156},
  language     = {eng},
  pages        = {57--64},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Diabetes Technology & Therapeutics},
  title        = {Delivering needle-free insulin using AERx (R) iDMS (Insulin Diabetes Management System) technology},
  url          = {http://dx.doi.org/10.1089/dia.2007.0206},
  volume       = {9},
  year         = {2007},
}