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Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells

Lindbom, John; Gustafsson, Mats; Blomqvist, Goran; Dahl, Andreas LU ; Gudmundsson, Anders LU ; Swietlicki, Erik LU and Ljungman, Anders G. (2007) In Chemical Research in Toxicology 20(6). p.937-946
Abstract
Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a... (More)
Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a subway station, and studded tire-pavement wear. Inflammatory effects were measured as induction of nitric oxide (NO), IL-6, TNF-alpha, arachidonic acid (AA), and lipid peroxidation after exposure of the murine macrophage like cell line RAW 264.7. In addition, the redox potential of the particles was measured in a cell-free system. The results show that all particles tested induce IL-6, TNF-alpha, and NO, and those from the urban street were the most potent ones. In contrast, particles collected from a subway station were most potent to induce lipid peroxidation, AA release, and formation of ROS. Particles from studded tire-pavement wear, generated using a road simulator, were able to induce inflammatory cytokines, NO, lipid peroxidation, and ROS formation. Interestingly, particles generated from pavement containing granite as the main stone material were more potent than those generated from pavement containing quartzite as the main stone material. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemical Research in Toxicology
volume
20
issue
6
pages
937 - 946
publisher
The American Chemical Society
external identifiers
  • wos:000247304200012
  • scopus:34447126941
ISSN
1520-5010
DOI
10.1021/tx700018z
language
English
LU publication?
yes
id
9fb56587-693b-4f97-bbb8-3195b23dd69f (old id 648549)
date added to LUP
2007-12-12 15:37:08
date last changed
2017-07-09 03:33:54
@article{9fb56587-693b-4f97-bbb8-3195b23dd69f,
  abstract     = {Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a subway station, and studded tire-pavement wear. Inflammatory effects were measured as induction of nitric oxide (NO), IL-6, TNF-alpha, arachidonic acid (AA), and lipid peroxidation after exposure of the murine macrophage like cell line RAW 264.7. In addition, the redox potential of the particles was measured in a cell-free system. The results show that all particles tested induce IL-6, TNF-alpha, and NO, and those from the urban street were the most potent ones. In contrast, particles collected from a subway station were most potent to induce lipid peroxidation, AA release, and formation of ROS. Particles from studded tire-pavement wear, generated using a road simulator, were able to induce inflammatory cytokines, NO, lipid peroxidation, and ROS formation. Interestingly, particles generated from pavement containing granite as the main stone material were more potent than those generated from pavement containing quartzite as the main stone material.},
  author       = {Lindbom, John and Gustafsson, Mats and Blomqvist, Goran and Dahl, Andreas and Gudmundsson, Anders and Swietlicki, Erik and Ljungman, Anders G.},
  issn         = {1520-5010},
  language     = {eng},
  number       = {6},
  pages        = {937--946},
  publisher    = {The American Chemical Society},
  series       = {Chemical Research in Toxicology},
  title        = {Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells},
  url          = {http://dx.doi.org/10.1021/tx700018z},
  volume       = {20},
  year         = {2007},
}