Viral capsids: Mechanical characteristics, genome packaging and delivery mechanisms
Roos, W. H. ; Ivanovska, I. L. ; Evilevitch, Alex LU
and Wuite, G. J. L.
(2007)
In Cellular and Molecular Life Sciences
64(12).
p.1484-1497
- Abstract
- The main functions of viral capsids are to protect, transport and deliver their genome. The mechanical properties of capsids are supposed to be adapted to these tasks. Bacteriophage capsids also need to withstand the high pressures the DNA is exerting onto it as a result of the DNA packaging and its consequent confinement within the capsid. It is proposed that this pressure helps driving the genome into the host, but other mechanisms also seem to play an important role in ejection. DNA packaging and ejection strategies are obviously dependent on the mechanical properties of the capsid. This review focuses on the mechanical properties of viral capsids in general and the elucidation of the biophysical aspects of genome packaging mechanisms... (More)
- The main functions of viral capsids are to protect, transport and deliver their genome. The mechanical properties of capsids are supposed to be adapted to these tasks. Bacteriophage capsids also need to withstand the high pressures the DNA is exerting onto it as a result of the DNA packaging and its consequent confinement within the capsid. It is proposed that this pressure helps driving the genome into the host, but other mechanisms also seem to play an important role in ejection. DNA packaging and ejection strategies are obviously dependent on the mechanical properties of the capsid. This review focuses on the mechanical properties of viral capsids in general and the elucidation of the biophysical aspects of genome packaging mechanisms and genome delivery processes of double-stranded DNA bacteriophages in particular. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/648569
- author
- Roos, W. H.
; Ivanovska, I. L.
; Evilevitch, Alex
LU
and Wuite, G. J. L.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biophysics, optical tweezers, atomic force microscopy, osmotic pressure, genome delivery, capsid mechanics, genome packaging
- in
- Cellular and Molecular Life Sciences
- volume
- 64
- issue
- 12
- pages
- 1484 - 1497
- publisher
- Birkhäuser
- external identifiers
-
- wos:000247272100005
- scopus:34250734534
- ISSN
- 1420-9071
- DOI
- 10.1007/s00018-007-6451-1
- language
- English
- LU publication?
- yes
- id
- 201e399a-602b-49d8-9c65-b8cd47cb9997 (old id 648569)
- date added to LUP
- 2016-04-01 15:55:28
- date last changed
- 2024-09-14 05:32:42
@article{201e399a-602b-49d8-9c65-b8cd47cb9997,
abstract = {{The main functions of viral capsids are to protect, transport and deliver their genome. The mechanical properties of capsids are supposed to be adapted to these tasks. Bacteriophage capsids also need to withstand the high pressures the DNA is exerting onto it as a result of the DNA packaging and its consequent confinement within the capsid. It is proposed that this pressure helps driving the genome into the host, but other mechanisms also seem to play an important role in ejection. DNA packaging and ejection strategies are obviously dependent on the mechanical properties of the capsid. This review focuses on the mechanical properties of viral capsids in general and the elucidation of the biophysical aspects of genome packaging mechanisms and genome delivery processes of double-stranded DNA bacteriophages in particular.}},
author = {{Roos, W. H. and Ivanovska, I. L. and Evilevitch, Alex and Wuite, G. J. L.}},
issn = {{1420-9071}},
keywords = {{biophysics; optical tweezers; atomic force microscopy; osmotic pressure; genome delivery; capsid mechanics; genome packaging}},
language = {{eng}},
number = {{12}},
pages = {{1484--1497}},
publisher = {{Birkhäuser}},
series = {{Cellular and Molecular Life Sciences}},
title = {{Viral capsids: Mechanical characteristics, genome packaging and delivery mechanisms}},
url = {{http://dx.doi.org/10.1007/s00018-007-6451-1}},
doi = {{10.1007/s00018-007-6451-1}},
volume = {{64}},
year = {{2007}},
}