Advanced

Magnetic CLEAR supports for solid-phase synthesis of peptides and small organic molecules

Sasikumar, Pottayil LU and Kempe, Maria LU (2007) In International Journal of Peptide Research and Therapeutics 13(1-2). p.129-141
Abstract
Paramagnetic versions of the CLEAR supports were prepared by entrapment of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of magnetic beads and regular CLEAR beads. The application of the magnetic beads as the support in solid-phase synthesis of peptides (Leu-enkephalinamide, substance P, acyl carrier protein (65-74) amide, and amyloid beta-protein (34-42) amide) and small organic affinity ligands based on the s-triazine scaffold was demonstrated. Adequate stability of the beads and retention of their magnetic properties were observed throughout the... (More)
Paramagnetic versions of the CLEAR supports were prepared by entrapment of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of magnetic beads and regular CLEAR beads. The application of the magnetic beads as the support in solid-phase synthesis of peptides (Leu-enkephalinamide, substance P, acyl carrier protein (65-74) amide, and amyloid beta-protein (34-42) amide) and small organic affinity ligands based on the s-triazine scaffold was demonstrated. Adequate stability of the beads and retention of their magnetic properties were observed throughout the synthesis steps. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
suspension polymerization, substance P, s-triazine scaffold, synthesis, solid-phase, resin, magnetite, magnetic support, Leu-enkephalin, CLEAR, acyl carrier protein (65-74), amyloid beta-protein (34-42)
in
International Journal of Peptide Research and Therapeutics
volume
13
issue
1-2
pages
129 - 141
publisher
Springer
external identifiers
  • wos:000247236500015
  • scopus:34250010087
ISSN
1573-3904
DOI
10.1007/s10989-006-9056-x
language
English
LU publication?
yes
id
6141cb5d-f80d-41f2-afc5-6ec96976c8a5 (old id 648866)
date added to LUP
2007-12-14 14:09:09
date last changed
2017-08-13 03:48:55
@article{6141cb5d-f80d-41f2-afc5-6ec96976c8a5,
  abstract     = {Paramagnetic versions of the CLEAR supports were prepared by entrapment of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of magnetic beads and regular CLEAR beads. The application of the magnetic beads as the support in solid-phase synthesis of peptides (Leu-enkephalinamide, substance P, acyl carrier protein (65-74) amide, and amyloid beta-protein (34-42) amide) and small organic affinity ligands based on the s-triazine scaffold was demonstrated. Adequate stability of the beads and retention of their magnetic properties were observed throughout the synthesis steps.},
  author       = {Sasikumar, Pottayil and Kempe, Maria},
  issn         = {1573-3904},
  keyword      = {suspension polymerization,substance P,s-triazine scaffold,synthesis,solid-phase,resin,magnetite,magnetic support,Leu-enkephalin,CLEAR,acyl carrier protein (65-74),amyloid beta-protein (34-42)},
  language     = {eng},
  number       = {1-2},
  pages        = {129--141},
  publisher    = {Springer},
  series       = {International Journal of Peptide Research and Therapeutics},
  title        = {Magnetic CLEAR supports for solid-phase synthesis of peptides and small organic molecules},
  url          = {http://dx.doi.org/10.1007/s10989-006-9056-x},
  volume       = {13},
  year         = {2007},
}