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Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice

Chen, Duan; Stenstrom, Bjorn; Zhao, Chun-Mei and Wadström, Torkel LU (2007) In Pathogens and Disease 50(2). p.184-189
Abstract
A role for Helicobacter pylori infection in the development of gastric cancer in humans is well established; however, evidence for its carcinogenicity in animals remains inadequate. Mongolian gerbils and mice are commonly used to investigate the carcinogenicity of H. pylori, yet it is unclear whether H. pylori infection per se causes gastric cancer or duodenal ulcers in these animal models. Gastric adenocarcinoma in the gerbils was reported over 10 years ago, but this species has proved an unreliable model for studying H. pylori infection-associated gastric cancer. Helicobacter pylori infection alone appears insufficient to induce gastric cancer in these animals; additional carcinogenic insult is required. The development of invasive... (More)
A role for Helicobacter pylori infection in the development of gastric cancer in humans is well established; however, evidence for its carcinogenicity in animals remains inadequate. Mongolian gerbils and mice are commonly used to investigate the carcinogenicity of H. pylori, yet it is unclear whether H. pylori infection per se causes gastric cancer or duodenal ulcers in these animal models. Gastric adenocarcinoma in the gerbils was reported over 10 years ago, but this species has proved an unreliable model for studying H. pylori infection-associated gastric cancer. Helicobacter pylori infection alone appears insufficient to induce gastric cancer in these animals; additional carcinogenic insult is required. The development of invasive adenocarcinoma in inbred mice is rare regardless of the mouse or bacterial strain, and many long-term studies have failed to induce gastric cancer in these animals. Helicobacter pylori infection is also an established causative factor for duodenal ulcer in humans. However, few studies have attempted to develop animal models of H. pylori infection-induced duodenal ulcer. We therefore conclude that both Mongolian gerbils and inbred mice may be inadequate models for studying H. pylori infection-associated gastric cancer and that there is no animal model of H. pylori infection-induced duodenal ulcer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ulcer, duodenal, gastric cancer, mice, Helicobacter pylori, Mongolian gerbils
in
Pathogens and Disease
volume
50
issue
2
pages
184 - 189
publisher
Wiley-Blackwell
external identifiers
  • wos:000247226000006
  • scopus:34250347652
ISSN
2049-632X
DOI
10.1111/j.1574-695X.2007.00249.x
language
English
LU publication?
yes
id
a55d72a8-b73a-4d63-bed3-abd3fd9dd22f (old id 648907)
date added to LUP
2007-12-10 09:37:39
date last changed
2017-02-05 03:29:15
@article{a55d72a8-b73a-4d63-bed3-abd3fd9dd22f,
  abstract     = {A role for Helicobacter pylori infection in the development of gastric cancer in humans is well established; however, evidence for its carcinogenicity in animals remains inadequate. Mongolian gerbils and mice are commonly used to investigate the carcinogenicity of H. pylori, yet it is unclear whether H. pylori infection per se causes gastric cancer or duodenal ulcers in these animal models. Gastric adenocarcinoma in the gerbils was reported over 10 years ago, but this species has proved an unreliable model for studying H. pylori infection-associated gastric cancer. Helicobacter pylori infection alone appears insufficient to induce gastric cancer in these animals; additional carcinogenic insult is required. The development of invasive adenocarcinoma in inbred mice is rare regardless of the mouse or bacterial strain, and many long-term studies have failed to induce gastric cancer in these animals. Helicobacter pylori infection is also an established causative factor for duodenal ulcer in humans. However, few studies have attempted to develop animal models of H. pylori infection-induced duodenal ulcer. We therefore conclude that both Mongolian gerbils and inbred mice may be inadequate models for studying H. pylori infection-associated gastric cancer and that there is no animal model of H. pylori infection-induced duodenal ulcer.},
  author       = {Chen, Duan and Stenstrom, Bjorn and Zhao, Chun-Mei and Wadström, Torkel},
  issn         = {2049-632X},
  keyword      = {ulcer,duodenal,gastric cancer,mice,Helicobacter pylori,Mongolian gerbils},
  language     = {eng},
  number       = {2},
  pages        = {184--189},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice},
  url          = {http://dx.doi.org/10.1111/j.1574-695X.2007.00249.x},
  volume       = {50},
  year         = {2007},
}