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The status of human nuclear transfer

Hall, Vanessa LU and Stojkovic, Miodrag (2006) In Stem Cell Reviews 2(4). p.301-308
Abstract
Human therapeutic cloning is a recently emerged application of somatic cell nuclear transfer (SCNT), which is currently being performed to produce patient-specific stem cell lines for future stem cell therapies. The advantages in producing human nuclear transfer (NT) embryos to derive NT stem cell lines are that these can be tailor-made (i.e., are autologous in nature) for the patient and may overcome the need to administer lifelong immunosuppression following; stem cell transplantation. Although the rationale for using NT embryos is not for reproductive purposes, human NT remains clouded in ethical, moral, and religious controversies. The recent retraction of high-impact factor publications in the field of human NT from a research group... (More)
Human therapeutic cloning is a recently emerged application of somatic cell nuclear transfer (SCNT), which is currently being performed to produce patient-specific stem cell lines for future stem cell therapies. The advantages in producing human nuclear transfer (NT) embryos to derive NT stem cell lines are that these can be tailor-made (i.e., are autologous in nature) for the patient and may overcome the need to administer lifelong immunosuppression following; stem cell transplantation. Although the rationale for using NT embryos is not for reproductive purposes, human NT remains clouded in ethical, moral, and religious controversies. The recent retraction of high-impact factor publications in the field of human NT from a research group in South Korea has placed stem cell research in a delicate situation. These heavily publicized issues may hinder the progress of this research and may threaten to bring current research to a complete halt. This review outlines the recent status of human NT, its continuing progress and the difficulties the field faces. Of most concern are the ethical issues, which surround obtaining human oocytes for research. Recent evidence suggests that failed-to-fertilize oocytes are poor sources for human SCNT, but obtaining fresh, viable oocytes may be even more problematic. The current status of human SCNT is outlined in this review with particular reference made to, lessons learnt from animal research, the oocyte dilemma and optimization of human NT. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
therapeutic cloning, embryonic stem, cells, patient-specific stem cell lines, microtubule, oocyte, nuclear transfer, somatic cell
in
Stem Cell Reviews
volume
2
issue
4
pages
301 - 308
publisher
Humana Press
external identifiers
  • wos:000246995900007
  • scopus:34848845792
ISSN
1558-6804
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
586c3724-4d6d-4c97-91e2-64a22f6b8641 (old id 649031)
alternative location
http://www.ingentaconnect.com/content/hum/scr/2006/00000002/00000004/art00007
date added to LUP
2016-04-01 12:09:06
date last changed
2021-09-22 01:33:23
@article{586c3724-4d6d-4c97-91e2-64a22f6b8641,
  abstract     = {Human therapeutic cloning is a recently emerged application of somatic cell nuclear transfer (SCNT), which is currently being performed to produce patient-specific stem cell lines for future stem cell therapies. The advantages in producing human nuclear transfer (NT) embryos to derive NT stem cell lines are that these can be tailor-made (i.e., are autologous in nature) for the patient and may overcome the need to administer lifelong immunosuppression following; stem cell transplantation. Although the rationale for using NT embryos is not for reproductive purposes, human NT remains clouded in ethical, moral, and religious controversies. The recent retraction of high-impact factor publications in the field of human NT from a research group in South Korea has placed stem cell research in a delicate situation. These heavily publicized issues may hinder the progress of this research and may threaten to bring current research to a complete halt. This review outlines the recent status of human NT, its continuing progress and the difficulties the field faces. Of most concern are the ethical issues, which surround obtaining human oocytes for research. Recent evidence suggests that failed-to-fertilize oocytes are poor sources for human SCNT, but obtaining fresh, viable oocytes may be even more problematic. The current status of human SCNT is outlined in this review with particular reference made to, lessons learnt from animal research, the oocyte dilemma and optimization of human NT.},
  author       = {Hall, Vanessa and Stojkovic, Miodrag},
  issn         = {1558-6804},
  language     = {eng},
  number       = {4},
  pages        = {301--308},
  publisher    = {Humana Press},
  series       = {Stem Cell Reviews},
  title        = {The status of human nuclear transfer},
  url          = {http://www.ingentaconnect.com/content/hum/scr/2006/00000002/00000004/art00007},
  volume       = {2},
  year         = {2006},
}