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Towards stem cell based therapies for parkinson’s disease

Parmar, Malin LU orcid (2018) In Development (Cambridge) 145(1).
Abstract

Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson’s disease. However, the use of fetal tissue is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary between countries. For decades, the field has therefore investigated new scalable source of therapeutic cells from stem cells or via reprogramming. Now it is possible to generate authentic midbrain dopaminergic neurons from pluripotent stem cells and clinical trials using such cells are rapidly approaching.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dopamine neuron, Parkinson’s disease, Reprogramming, Stem cell, Translation
in
Development (Cambridge)
volume
145
issue
1
article number
dev156117
publisher
The Company of Biologists Ltd
external identifiers
  • scopus:85040777882
  • pmid:29311261
ISSN
0950-1991
DOI
10.1242/dev.156117
language
English
LU publication?
yes
id
64af99a9-7bc8-426e-88bf-dd3dea17a0ef
date added to LUP
2018-01-30 13:43:56
date last changed
2021-10-10 03:46:18
@article{64af99a9-7bc8-426e-88bf-dd3dea17a0ef,
  abstract     = {<p>Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson’s disease. However, the use of fetal tissue is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary between countries. For decades, the field has therefore investigated new scalable source of therapeutic cells from stem cells or via reprogramming. Now it is possible to generate authentic midbrain dopaminergic neurons from pluripotent stem cells and clinical trials using such cells are rapidly approaching.</p>},
  author       = {Parmar, Malin},
  issn         = {0950-1991},
  language     = {eng},
  month        = {01},
  number       = {1},
  publisher    = {The Company of Biologists Ltd},
  series       = {Development (Cambridge)},
  title        = {Towards stem cell based therapies for parkinson’s disease},
  url          = {http://dx.doi.org/10.1242/dev.156117},
  doi          = {10.1242/dev.156117},
  volume       = {145},
  year         = {2018},
}