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Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment : DiMoPEx-project is designed to determine the impacts of environmental exposure on human health

Budnik, Lygia Therese ; Adam, Balazs ; Albin, Maria LU ; Banelli, Barbara ; Baur, Xaver ; Belpoggi, Fiorella ; Bolognesi, Claudia ; Broberg, Karin LU ; Gustavsson, Per LU and Göen, Thomas , et al. (2018) In Journal of Occupational Medicine and Toxicology 13(1).
Abstract

The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies. Research addressing the links between environmental exposure and disease prevalence is key for prevention of the pandemic increase in NCD morbidity and mortality. However, the long latency, the chronic course of some diseases... (More)

The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies. Research addressing the links between environmental exposure and disease prevalence is key for prevention of the pandemic increase in NCD morbidity and mortality. However, the long latency, the chronic course of some diseases and the necessity to address cumulative exposures over very long periods does mean that it is often difficult to identify causal environmental exposures. EU-funded COST Action DiMoPEx is developing new concepts for a better understanding of health-environment (including gene-environment) interactions in the etiology of NCDs. The overarching idea is to teach and train scientists and physicians to learn how to include efficient and valid exposure assessments in their research and in their clinical practice in current and future cooperative projects. DiMoPEx partners have identified some of the emerging research needs, which include the lack of evidence-based exposure data and the need for human-equivalent animal models mirroring human lifespan and low-dose cumulative exposures. Utilizing an interdisciplinary approach incorporating seven working groups, DiMoPEx will focus on aspects of air pollution with particulate matter including dust and fibers and on exposure to low doses of solvents and sensitizing agents. Biomarkers of early exposure and their associated effects as indicators of disease-derived information will be tested and standardized within individual projects. Risks arising from some NCDs, like pneumoconioses, cancers and allergies, are predictable and preventable. Consequently, preventative action could lead to decreasing disease morbidity and mortality for many of the NCDs that are of major public concern. DiMoPEx plans to catalyze and stimulate interaction of scientists with policy-makers in attacking these exposure-related diseases.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Environmental/occupational exposure to xenobiotics, Human biomonitoring, Noncommunicable diseases
in
Journal of Occupational Medicine and Toxicology
volume
13
issue
1
article number
6
pages
22 pages
publisher
BioMed Central (BMC)
external identifiers
  • pmid:29441119
  • scopus:85041408932
ISSN
1745-6673
DOI
10.1186/s12995-018-0186-9
language
English
LU publication?
yes
id
6505d680-fb46-459f-8e54-d99ef382d314
date added to LUP
2018-03-06 11:10:37
date last changed
2020-10-27 01:59:35
@article{6505d680-fb46-459f-8e54-d99ef382d314,
  abstract     = {<p>The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies. Research addressing the links between environmental exposure and disease prevalence is key for prevention of the pandemic increase in NCD morbidity and mortality. However, the long latency, the chronic course of some diseases and the necessity to address cumulative exposures over very long periods does mean that it is often difficult to identify causal environmental exposures. EU-funded COST Action DiMoPEx is developing new concepts for a better understanding of health-environment (including gene-environment) interactions in the etiology of NCDs. The overarching idea is to teach and train scientists and physicians to learn how to include efficient and valid exposure assessments in their research and in their clinical practice in current and future cooperative projects. DiMoPEx partners have identified some of the emerging research needs, which include the lack of evidence-based exposure data and the need for human-equivalent animal models mirroring human lifespan and low-dose cumulative exposures. Utilizing an interdisciplinary approach incorporating seven working groups, DiMoPEx will focus on aspects of air pollution with particulate matter including dust and fibers and on exposure to low doses of solvents and sensitizing agents. Biomarkers of early exposure and their associated effects as indicators of disease-derived information will be tested and standardized within individual projects. Risks arising from some NCDs, like pneumoconioses, cancers and allergies, are predictable and preventable. Consequently, preventative action could lead to decreasing disease morbidity and mortality for many of the NCDs that are of major public concern. DiMoPEx plans to catalyze and stimulate interaction of scientists with policy-makers in attacking these exposure-related diseases.</p>},
  author       = {Budnik, Lygia Therese and Adam, Balazs and Albin, Maria and Banelli, Barbara and Baur, Xaver and Belpoggi, Fiorella and Bolognesi, Claudia and Broberg, Karin and Gustavsson, Per and Göen, Thomas and Fischer, Axel and Jarosinska, Dorota and Manservisi, Fabiana and O'Kennedy, Richard and Øvrevik, Johan and Paunovic, Elizabet and Ritz, Beate and Scheepers, Paul T.J. and Schlünssen, Vivi and Schwarzenbach, Heidi and Schwarze, Per E. and Sheils, Orla and Sigsgaard, Torben and Van Damme, Karel and Casteleyn, Ludwine},
  issn         = {1745-6673},
  language     = {eng},
  month        = {02},
  number       = {1},
  publisher    = {BioMed Central (BMC)},
  series       = {Journal of Occupational Medicine and Toxicology},
  title        = {Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment : DiMoPEx-project is designed to determine the impacts of environmental exposure on human health},
  url          = {http://dx.doi.org/10.1186/s12995-018-0186-9},
  doi          = {10.1186/s12995-018-0186-9},
  volume       = {13},
  year         = {2018},
}