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Allergens as eukaryotic proteins lacking bacterial homologues

Emanuelsson, Cecilia LU and Spangfort, Michael D. (2007) In Molecular Immunology 44(12). p.3256-3260
Abstract
Only a small number of protein homologues cause the majority of allergies. There is no consensus structure or other obvious common denominator discriminating the few proteins that are allergens from thousands of other, non-allergenic proteins. By database sequence homology searching, we here show that to date known allergen sequences have no or few bacterial homologues, in contrast to randomly selected control protein sequences. This finding suggests a novel common denominator for allergens of potential use for allergen prediction programs. A possible interpretation of this finding is that allergens are proteins which are exposed to the immune system and which lack bacterial homologues. This interpretation is discussed in relation to the... (More)
Only a small number of protein homologues cause the majority of allergies. There is no consensus structure or other obvious common denominator discriminating the few proteins that are allergens from thousands of other, non-allergenic proteins. By database sequence homology searching, we here show that to date known allergen sequences have no or few bacterial homologues, in contrast to randomly selected control protein sequences. This finding suggests a novel common denominator for allergens of potential use for allergen prediction programs. A possible interpretation of this finding is that allergens are proteins which are exposed to the immune system and which lack bacterial homologues. This interpretation is discussed in relation to the many observations that allergies coincide with a delayed establishment of infant gut flora. (c) 2007 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hygiene hypothesis, homology searching, allergen, allergen prediction
in
Molecular Immunology
volume
44
issue
12
pages
3256 - 3260
publisher
Pergamon
external identifiers
  • wos:000246921500020
  • scopus:34247218466
ISSN
1872-9142
DOI
10.1016/j.molimm.2007.01.019
language
English
LU publication?
yes
id
108a54cf-e9d2-4f09-8e11-d5709ad0a27d (old id 650722)
date added to LUP
2007-12-11 13:36:27
date last changed
2017-01-01 07:19:46
@article{108a54cf-e9d2-4f09-8e11-d5709ad0a27d,
  abstract     = {Only a small number of protein homologues cause the majority of allergies. There is no consensus structure or other obvious common denominator discriminating the few proteins that are allergens from thousands of other, non-allergenic proteins. By database sequence homology searching, we here show that to date known allergen sequences have no or few bacterial homologues, in contrast to randomly selected control protein sequences. This finding suggests a novel common denominator for allergens of potential use for allergen prediction programs. A possible interpretation of this finding is that allergens are proteins which are exposed to the immune system and which lack bacterial homologues. This interpretation is discussed in relation to the many observations that allergies coincide with a delayed establishment of infant gut flora. (c) 2007 Elsevier Ltd. All rights reserved.},
  author       = {Emanuelsson, Cecilia and Spangfort, Michael D.},
  issn         = {1872-9142},
  keyword      = {hygiene hypothesis,homology searching,allergen,allergen prediction},
  language     = {eng},
  number       = {12},
  pages        = {3256--3260},
  publisher    = {Pergamon},
  series       = {Molecular Immunology},
  title        = {Allergens as eukaryotic proteins lacking bacterial homologues},
  url          = {http://dx.doi.org/10.1016/j.molimm.2007.01.019},
  volume       = {44},
  year         = {2007},
}