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OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis

Gossec, Laure; Hawker, Gillian; Davis, Aileen M.; Maillefert, Jean Francis; Lohmander, Stefan LU ; Altman, Roy; Cibere, Jolanda; Conaghan, Philip G.; Hochberg, Marc C. and Jordan, Joanne M., et al. (2007) In Journal of Rheumatology 34(6). p.1432-1435
Abstract
Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." Methods. For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices - the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and... (More)
Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." Methods. For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices - the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. Results. For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. Conclusion. Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials. (Less)
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Contribution to journal
publication status
published
subject
keywords
structure, function, pain, osteoarthritis, severity, outcome measure
in
Journal of Rheumatology
volume
34
issue
6
pages
1432 - 1435
publisher
J Rheumatol Publ Co
external identifiers
  • wos:000247116600035
  • scopus:34250181733
ISSN
0315-162X
language
English
LU publication?
yes
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41e43763-66e1-4a84-a2f0-869f03866f95 (old id 650760)
alternative location
http://www.jrheum.com/subscribers/07/06/1432.html
date added to LUP
2007-12-07 12:41:52
date last changed
2017-05-21 03:46:12
@article{41e43763-66e1-4a84-a2f0-869f03866f95,
  abstract     = {Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." Methods. For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices - the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. Results. For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. Conclusion. Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.},
  author       = {Gossec, Laure and Hawker, Gillian and Davis, Aileen M. and Maillefert, Jean Francis and Lohmander, Stefan and Altman, Roy and Cibere, Jolanda and Conaghan, Philip G. and Hochberg, Marc C. and Jordan, Joanne M. and Katz, Jeffrey N. and March, Lyn and Mahomed, Nizar and Pavelka, Karel and Roos, Ewa and Suarez-Almazor, Maria E. and Zanoli, Gustavo and Dougados, Maxime},
  issn         = {0315-162X},
  keyword      = {structure,function,pain,osteoarthritis,severity,outcome measure},
  language     = {eng},
  number       = {6},
  pages        = {1432--1435},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis},
  volume       = {34},
  year         = {2007},
}