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Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies

Nilsson, Björn LU ; Johnels, Petra LU ; Johansson, Mikael ; Nelander, Sven and Fioretos, Thoas LU (2007) In Genome Biology 8(5).
Abstract
Ontological analysis facilitates microarray data interpretation. We describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful. We perform extensive evaluations and introduce a new concept, detection spectra, to characterize methods. We show that different ontological analysis methods exhibit distinct detection spectra, and that it is critical to account for this diversity. Our results argue strongly against the continued use of existing methods, and provide directions towards an enhanced approach.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genome Biology
volume
8
issue
5
publisher
BioMed Central (BMC)
external identifiers
  • wos:000246983100026
  • scopus:34548812620
  • pmid:17488501
ISSN
1474-7596
DOI
10.1186/gb-2007-8-5-r74
language
English
LU publication?
yes
id
e3aca1ed-f631-4fbc-98d5-da76c57385c9 (old id 651068)
date added to LUP
2016-04-01 12:17:37
date last changed
2022-03-21 02:12:02
@article{e3aca1ed-f631-4fbc-98d5-da76c57385c9,
  abstract     = {{Ontological analysis facilitates microarray data interpretation. We describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful. We perform extensive evaluations and introduce a new concept, detection spectra, to characterize methods. We show that different ontological analysis methods exhibit distinct detection spectra, and that it is critical to account for this diversity. Our results argue strongly against the continued use of existing methods, and provide directions towards an enhanced approach.}},
  author       = {{Nilsson, Björn and Johnels, Petra and Johansson, Mikael and Nelander, Sven and Fioretos, Thoas}},
  issn         = {{1474-7596}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Genome Biology}},
  title        = {{Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies}},
  url          = {{http://dx.doi.org/10.1186/gb-2007-8-5-r74}},
  doi          = {{10.1186/gb-2007-8-5-r74}},
  volume       = {{8}},
  year         = {{2007}},
}