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Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis

Liu, Yingchun LU and Ringnér, Markus LU (2007) In Genome Biology 8(5).
Abstract
Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation result in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genome Biology
volume
8
issue
5
publisher
BioMed Central
external identifiers
  • wos:000246983100028
  • scopus:34548813411
ISSN
1474-7596
DOI
10.1186/gb-2007-8-5-r77
project
CREATE Health
language
English
LU publication?
yes
id
29de0fb3-073b-4d66-b1fd-d4fad4a5bdc6 (old id 651074)
date added to LUP
2007-12-13 09:09:39
date last changed
2017-01-01 04:42:21
@article{29de0fb3-073b-4d66-b1fd-d4fad4a5bdc6,
  abstract     = {Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation result in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures.},
  articleno    = {R77},
  author       = {Liu, Yingchun and Ringnér, Markus},
  issn         = {1474-7596},
  language     = {eng},
  number       = {5},
  publisher    = {BioMed Central},
  series       = {Genome Biology},
  title        = {Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis},
  url          = {http://dx.doi.org/10.1186/gb-2007-8-5-r77},
  volume       = {8},
  year         = {2007},
}