Advanced

Risk of malignant disease among 1525 adult male US veterans with gaucher disease

Landgren, Ola; Turesson, Ingemar LU ; Gridley, Gloria and Caporaso, Neil E. (2007) In Archives of Internal Medicine 167(11). p.1189-1194
Abstract
Background: Some, but not all, reports suggest that patients with Gaucher disease are at increased risk of developing malignancies, particularly hematopoietic tumors. The aim of this study was to assess the pattern of Gaucher disease and subsequent malignancies among male veterans admitted to US Veterans Affairs hospitals. Methods: Among 832 294 African American and 3 668 983 white male veterans with at least 1 hospital admission in US Veterans Affairs hospitals and up to 27 years of follow-up, we identified a total of 1525 patients with Gaucher disease; 11.7% were African Americans. We used Poisson regression methods for cohort data to estimate relative risks ( RRs) and 95% confidence intervals ( CIs) after adjusting for attained age and... (More)
Background: Some, but not all, reports suggest that patients with Gaucher disease are at increased risk of developing malignancies, particularly hematopoietic tumors. The aim of this study was to assess the pattern of Gaucher disease and subsequent malignancies among male veterans admitted to US Veterans Affairs hospitals. Methods: Among 832 294 African American and 3 668 983 white male veterans with at least 1 hospital admission in US Veterans Affairs hospitals and up to 27 years of follow-up, we identified a total of 1525 patients with Gaucher disease; 11.7% were African Americans. We used Poisson regression methods for cohort data to estimate relative risks ( RRs) and 95% confidence intervals ( CIs) after adjusting for attained age and calendar year, race, number of hospital visits, and latency. Results: When patients with Gaucher disease were compared with patients without Gaucher disease, the RR of any cancer was 0.91 ( 95% CI, 0.76-1.08 [ n = 137]). When we stratified our analyses by race, risks were similar for whites ( RR, 0.89; 95% CI, 0.74-1.07 [ n = 120]) and African Americans ( RR, 1.00; 95% CI, 0.61-1.64 [ n = 17]). Patients with Gaucher disease had an elevated risk for non-Hodgkin lymphoma ( RR, 2.54; 95% CI, 1.32-4.88 [ n = 9]), malignant melanoma ( RR, 3.07; 95% CI, 1.28-7.38 [ n = 5]), and pancreatic cancer ( RR, 2.37; 95% CI, 1.13-4.98 [ n = 7]). Among the remaining 19 cases involving defined solid tumors and 7 other hematologic malignancies, we found no statistical association with Gaucher disease. Conclusion: We found 2- to 3-fold risks of non-Hodgkin lymphoma, malignant melanoma, and pancreatic cancer in patients with Gaucher disease, but no significant association between Gaucher disease and cancer in general or with other specific malignancies such as multiple myeloma. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Internal Medicine
volume
167
issue
11
pages
1189 - 1194
publisher
American Medical Association
external identifiers
  • wos:000247143400013
  • scopus:34250312047
ISSN
0003-9926
language
English
LU publication?
yes
id
62559e95-2b4d-447a-b240-404d138506df (old id 651184)
alternative location
http://archinte.ama-assn.org/cgi/content/abstract/167/11/1189
date added to LUP
2007-12-14 12:48:43
date last changed
2017-07-02 03:37:23
@article{62559e95-2b4d-447a-b240-404d138506df,
  abstract     = {Background: Some, but not all, reports suggest that patients with Gaucher disease are at increased risk of developing malignancies, particularly hematopoietic tumors. The aim of this study was to assess the pattern of Gaucher disease and subsequent malignancies among male veterans admitted to US Veterans Affairs hospitals. Methods: Among 832 294 African American and 3 668 983 white male veterans with at least 1 hospital admission in US Veterans Affairs hospitals and up to 27 years of follow-up, we identified a total of 1525 patients with Gaucher disease; 11.7% were African Americans. We used Poisson regression methods for cohort data to estimate relative risks ( RRs) and 95% confidence intervals ( CIs) after adjusting for attained age and calendar year, race, number of hospital visits, and latency. Results: When patients with Gaucher disease were compared with patients without Gaucher disease, the RR of any cancer was 0.91 ( 95% CI, 0.76-1.08 [ n = 137]). When we stratified our analyses by race, risks were similar for whites ( RR, 0.89; 95% CI, 0.74-1.07 [ n = 120]) and African Americans ( RR, 1.00; 95% CI, 0.61-1.64 [ n = 17]). Patients with Gaucher disease had an elevated risk for non-Hodgkin lymphoma ( RR, 2.54; 95% CI, 1.32-4.88 [ n = 9]), malignant melanoma ( RR, 3.07; 95% CI, 1.28-7.38 [ n = 5]), and pancreatic cancer ( RR, 2.37; 95% CI, 1.13-4.98 [ n = 7]). Among the remaining 19 cases involving defined solid tumors and 7 other hematologic malignancies, we found no statistical association with Gaucher disease. Conclusion: We found 2- to 3-fold risks of non-Hodgkin lymphoma, malignant melanoma, and pancreatic cancer in patients with Gaucher disease, but no significant association between Gaucher disease and cancer in general or with other specific malignancies such as multiple myeloma.},
  author       = {Landgren, Ola and Turesson, Ingemar and Gridley, Gloria and Caporaso, Neil E.},
  issn         = {0003-9926},
  language     = {eng},
  number       = {11},
  pages        = {1189--1194},
  publisher    = {American Medical Association},
  series       = {Archives of Internal Medicine},
  title        = {Risk of malignant disease among 1525 adult male US veterans with gaucher disease},
  volume       = {167},
  year         = {2007},
}