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Pooled analysis and meta-analysis of the glutathione S-transferase P1 lle 105Val polymorphism and bladder cancer: A HuGE-GSEC review

Kellen, Eliane; Hemelt, Marjolein; Broberg Palmgren, Karin LU ; Golka, Klaus; Kristensen, Vessela Nedelcheva; Hung, Rayjean J.; Matullo, Giuseppe; Mittal, Rama D.; Porru, Stefano and Povey, Andrew, et al. (2007) In American Journal of Epidemiology 165(11). p.1221-1230
Abstract
The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% confidence interval: 1.21,1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be... (More)
The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% confidence interval: 1.21,1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 lle 105Val appears to be associated with a modest increase in the risk of bladder cancer. (Less)
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Contribution to journal
publication status
published
subject
keywords
urinary bladder neoplasms, GSTP1, meta-analysis
in
American Journal of Epidemiology
volume
165
issue
11
pages
1221 - 1230
publisher
Oxford University Press
external identifiers
  • wos:000247005500001
  • scopus:34447292550
ISSN
0002-9262
DOI
10.1093/aje/kwm003
language
English
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yes
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82e26dcd-3702-4fd0-a2d3-dd463954e289 (old id 651212)
date added to LUP
2007-12-12 13:57:12
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2017-07-09 03:37:21
@article{82e26dcd-3702-4fd0-a2d3-dd463954e289,
  abstract     = {The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% confidence interval: 1.21,1.99; p &lt; 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 lle 105Val appears to be associated with a modest increase in the risk of bladder cancer.},
  author       = {Kellen, Eliane and Hemelt, Marjolein and Broberg Palmgren, Karin and Golka, Klaus and Kristensen, Vessela Nedelcheva and Hung, Rayjean J. and Matullo, Giuseppe and Mittal, Rama D. and Porru, Stefano and Povey, Andrew and Schulz, Wolfgang A. and Shen, Jianhua and Buntinx, Frank and Zeegers, Maurice P. and Taioli, Emanuela},
  issn         = {0002-9262},
  keyword      = {urinary bladder neoplasms,GSTP1,meta-analysis},
  language     = {eng},
  number       = {11},
  pages        = {1221--1230},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Pooled analysis and meta-analysis of the glutathione S-transferase P1 lle 105Val polymorphism and bladder cancer: A HuGE-GSEC review},
  url          = {http://dx.doi.org/10.1093/aje/kwm003},
  volume       = {165},
  year         = {2007},
}