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Medicinal Plants in the Treatment of Peptic Ulcer Disease : A Review

Ardalani, Hamidreza LU ; Hadipanah, Amin and Sahebkar, Amirhossein (2020) In Mini-Reviews in Medicinal Chemistry 20(8). p.662-702
Abstract

Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum, which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive and defensive factors and Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and antibiotics are frequently used for the treatment. Recently, medicinal plants have emerged as efficacious, safe and widely available alternative therapies for PUD. The aim of this review was to study the medicinal plants and phytochemicals, which have been used for PUD treatment to evaluate the potential role of natural compounds to develop herbal remedies for PUD. Information was obtained using a literature search of electronic databases, such as... (More)

Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum, which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive and defensive factors and Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and antibiotics are frequently used for the treatment. Recently, medicinal plants have emerged as efficacious, safe and widely available alternative therapies for PUD. The aim of this review was to study the medicinal plants and phytochemicals, which have been used for PUD treatment to evaluate the potential role of natural compounds to develop herbal remedies for PUD. Information was obtained using a literature search of electronic databases, such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys and Cochrane. Common and scientific names of the plants and keywords such as 'peptic ulcer', 'gastric ulcer', 'stomach ulcer' and 'duodenal ulcer' were used for search. Eventually, 279 plants from 89 families were identified and information on the plant families, part of the plant used, chemical constituents, extracts, ulcer model used and dosage were abstracted. The results indicated that most of the anti-PUD plants were from Asteraceae (7.1%) and Fabaceae (6.8%) families while flavonoids (49%), tannins (13%), saponins (10%) and alkaloids (9%) were the most common natural compounds in plants with anti-PUD activity.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Anti-Inflammatory Agents, Non-Steroidal/chemistry, Humans, Molecular Structure, Peptic Ulcer/drug therapy, Plants, Medicinal/chemistry
in
Mini-Reviews in Medicinal Chemistry
volume
20
issue
8
pages
41 pages
publisher
Bentham Science Publishers
external identifiers
  • scopus:85082753075
  • pmid:31880244
ISSN
1875-5607
DOI
10.2174/1389557520666191227151939
language
English
LU publication?
no
id
651fc40d-49bb-45f5-adbb-cc167f4a7995
date added to LUP
2021-06-01 20:57:27
date last changed
2024-03-08 13:12:53
@article{651fc40d-49bb-45f5-adbb-cc167f4a7995,
  abstract     = {{<p>Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum, which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive and defensive factors and Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and antibiotics are frequently used for the treatment. Recently, medicinal plants have emerged as efficacious, safe and widely available alternative therapies for PUD. The aim of this review was to study the medicinal plants and phytochemicals, which have been used for PUD treatment to evaluate the potential role of natural compounds to develop herbal remedies for PUD. Information was obtained using a literature search of electronic databases, such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys and Cochrane. Common and scientific names of the plants and keywords such as 'peptic ulcer', 'gastric ulcer', 'stomach ulcer' and 'duodenal ulcer' were used for search. Eventually, 279 plants from 89 families were identified and information on the plant families, part of the plant used, chemical constituents, extracts, ulcer model used and dosage were abstracted. The results indicated that most of the anti-PUD plants were from Asteraceae (7.1%) and Fabaceae (6.8%) families while flavonoids (49%), tannins (13%), saponins (10%) and alkaloids (9%) were the most common natural compounds in plants with anti-PUD activity.</p>}},
  author       = {{Ardalani, Hamidreza and Hadipanah, Amin and Sahebkar, Amirhossein}},
  issn         = {{1875-5607}},
  keywords     = {{Animals; Anti-Inflammatory Agents, Non-Steroidal/chemistry; Humans; Molecular Structure; Peptic Ulcer/drug therapy; Plants, Medicinal/chemistry}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{8}},
  pages        = {{662--702}},
  publisher    = {{Bentham Science Publishers}},
  series       = {{Mini-Reviews in Medicinal Chemistry}},
  title        = {{Medicinal Plants in the Treatment of Peptic Ulcer Disease : A Review}},
  url          = {{http://dx.doi.org/10.2174/1389557520666191227151939}},
  doi          = {{10.2174/1389557520666191227151939}},
  volume       = {{20}},
  year         = {{2020}},
}