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Opioid use prior to total knee replacement : comparative analysis of trends in England and Sweden

Yu, D. ; Hellberg, C. LU ; Appleyard, T. ; Dell'Isola, A. LU ; Thomas, G. E.R. ; Turkiewicz, A. LU ; Englund, M. LU orcid and Peat, G. (2022) In Osteoarthritis and Cartilage 30(6). p.815-822
Abstract

Objectives: To describe and compare trends in the frequency of opioid prescribing/dispensing in English and Swedish patients with osteoarthritis prior to total knee replacement (TKR). Methods: 49,043 patients from an English national database (Clinical Practice Research Datalink) and 5,955 patients from the Swedish Skåne Healthcare register undergoing TKR between 2015 and 2019 were included, alongside 1:1 age-, sex-, and practice (residential area) matched controls. Annual prevalence and prevalence rates ratio (PRR) of opioid prescribing/dispensing (any, by strength) in the 10 years prior to TKR (or matched index date for controls) were estimated using Poisson regression. Results: In England and Sweden, the prevalence of patients with... (More)

Objectives: To describe and compare trends in the frequency of opioid prescribing/dispensing in English and Swedish patients with osteoarthritis prior to total knee replacement (TKR). Methods: 49,043 patients from an English national database (Clinical Practice Research Datalink) and 5,955 patients from the Swedish Skåne Healthcare register undergoing TKR between 2015 and 2019 were included, alongside 1:1 age-, sex-, and practice (residential area) matched controls. Annual prevalence and prevalence rates ratio (PRR) of opioid prescribing/dispensing (any, by strength) in the 10 years prior to TKR (or matched index date for controls) were estimated using Poisson regression. Results: In England and Sweden, the prevalence of patients with osteoarthritis receiving any opioid prior to TKR increased towards the date of surgery from 24% to 44% in England and from 16% to 33% in Sweden. Prescribing in controls was stable, resulting in an increasing PRR (1.6–2.7) between 10 and 1 years prior to index date in both countries. No relevant cohort or period effect was observed in either country. Prevalence of opioid prescribing was higher in English cases and controls; weaker opioids were more commonly prescribed in England, stronger opioids in Sweden. Conclusions: Temporal prevalence patterns of opioid prescribing between cases and controls are similar in England and Sweden. Opioids are still commonly used in TKR cases in both countries highlighting the lack of valid alternatives for OA pain management.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Electronic health care record, Opioid, Total knee replacement
in
Osteoarthritis and Cartilage
volume
30
issue
6
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85127851819
  • pmid:35307536
ISSN
1063-4584
DOI
10.1016/j.joca.2022.02.621
language
English
LU publication?
yes
id
6522c42e-cad6-414c-9788-97af13917c03
date added to LUP
2022-06-28 10:49:40
date last changed
2024-06-12 05:43:57
@article{6522c42e-cad6-414c-9788-97af13917c03,
  abstract     = {{<p>Objectives: To describe and compare trends in the frequency of opioid prescribing/dispensing in English and Swedish patients with osteoarthritis prior to total knee replacement (TKR). Methods: 49,043 patients from an English national database (Clinical Practice Research Datalink) and 5,955 patients from the Swedish Skåne Healthcare register undergoing TKR between 2015 and 2019 were included, alongside 1:1 age-, sex-, and practice (residential area) matched controls. Annual prevalence and prevalence rates ratio (PRR) of opioid prescribing/dispensing (any, by strength) in the 10 years prior to TKR (or matched index date for controls) were estimated using Poisson regression. Results: In England and Sweden, the prevalence of patients with osteoarthritis receiving any opioid prior to TKR increased towards the date of surgery from 24% to 44% in England and from 16% to 33% in Sweden. Prescribing in controls was stable, resulting in an increasing PRR (1.6–2.7) between 10 and 1 years prior to index date in both countries. No relevant cohort or period effect was observed in either country. Prevalence of opioid prescribing was higher in English cases and controls; weaker opioids were more commonly prescribed in England, stronger opioids in Sweden. Conclusions: Temporal prevalence patterns of opioid prescribing between cases and controls are similar in England and Sweden. Opioids are still commonly used in TKR cases in both countries highlighting the lack of valid alternatives for OA pain management.</p>}},
  author       = {{Yu, D. and Hellberg, C. and Appleyard, T. and Dell'Isola, A. and Thomas, G. E.R. and Turkiewicz, A. and Englund, M. and Peat, G.}},
  issn         = {{1063-4584}},
  keywords     = {{Electronic health care record; Opioid; Total knee replacement}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{815--822}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage}},
  title        = {{Opioid use prior to total knee replacement : comparative analysis of trends in England and Sweden}},
  url          = {{http://dx.doi.org/10.1016/j.joca.2022.02.621}},
  doi          = {{10.1016/j.joca.2022.02.621}},
  volume       = {{30}},
  year         = {{2022}},
}