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Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent

Hedner, Ulla LU and Brun, Nikolai C. (2007) In Neuroradiology 49(10). p.789-793
Abstract
Recombinant activated coagulation factor VII (rFVIIa) was developed for the treatment of patients with hemophilia who have developed inhibitors against the factor they are missing. Hemophilia is a serious bleeding disorder and patients with hemophilia develop repeated spontaneous CNS, joint and muscle bleeding. Any trauma, even mild events, may cause life-threatening bleeding, and without treatment, these patients have a life expectancy of about 16 years. Thus, hemophilia can be regarded as a model of severe bleeding, and an agent capable of inducing hemostasis in severe hemophilia independent of the hemophilia proteins (FVIII or FIX) may also be effective in patients without hemophilia who experience serious bleeds. The availability of... (More)
Recombinant activated coagulation factor VII (rFVIIa) was developed for the treatment of patients with hemophilia who have developed inhibitors against the factor they are missing. Hemophilia is a serious bleeding disorder and patients with hemophilia develop repeated spontaneous CNS, joint and muscle bleeding. Any trauma, even mild events, may cause life-threatening bleeding, and without treatment, these patients have a life expectancy of about 16 years. Thus, hemophilia can be regarded as a model of severe bleeding, and an agent capable of inducing hemostasis in severe hemophilia independent of the hemophilia proteins (FVIII or FIX) may also be effective in patients without hemophilia who experience serious bleeds. The availability of rFVIIa stimulated research on the role of FVII and tissue factor (TF) in the hemostatic process. As a result, a picture partly different from the one suggested by previous models [1, 2] has emerged. These previous models basically neglected the role of cells and cell membranes. The importance of platelets and platelet membrane phospholipids in hemostasis has been demonstrated, and the new concept of the hemostatic process, focusing on cell surfaces, has been outlined. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
VIIa, tissue factor, intracerebral hemorrhage, recombinant coagulation factor, hemostasis
in
Neuroradiology
volume
49
issue
10
pages
789 - 793
publisher
Springer Verlag
external identifiers
  • wos:000249794400001
  • scopus:34848838263
ISSN
1432-1920
DOI
10.1007/s00234-007-0240-2
language
English
LU publication?
yes
id
493c0abe-5b97-4233-b68b-f467b52aa9f9 (old id 653964)
date added to LUP
2007-12-11 09:19:04
date last changed
2017-01-01 04:41:26
@article{493c0abe-5b97-4233-b68b-f467b52aa9f9,
  abstract     = {Recombinant activated coagulation factor VII (rFVIIa) was developed for the treatment of patients with hemophilia who have developed inhibitors against the factor they are missing. Hemophilia is a serious bleeding disorder and patients with hemophilia develop repeated spontaneous CNS, joint and muscle bleeding. Any trauma, even mild events, may cause life-threatening bleeding, and without treatment, these patients have a life expectancy of about 16 years. Thus, hemophilia can be regarded as a model of severe bleeding, and an agent capable of inducing hemostasis in severe hemophilia independent of the hemophilia proteins (FVIII or FIX) may also be effective in patients without hemophilia who experience serious bleeds. The availability of rFVIIa stimulated research on the role of FVII and tissue factor (TF) in the hemostatic process. As a result, a picture partly different from the one suggested by previous models [1, 2] has emerged. These previous models basically neglected the role of cells and cell membranes. The importance of platelets and platelet membrane phospholipids in hemostasis has been demonstrated, and the new concept of the hemostatic process, focusing on cell surfaces, has been outlined.},
  author       = {Hedner, Ulla and Brun, Nikolai C.},
  issn         = {1432-1920},
  keyword      = {VIIa,tissue factor,intracerebral hemorrhage,recombinant coagulation factor,hemostasis},
  language     = {eng},
  number       = {10},
  pages        = {789--793},
  publisher    = {Springer Verlag},
  series       = {Neuroradiology},
  title        = {Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent},
  url          = {http://dx.doi.org/10.1007/s00234-007-0240-2},
  volume       = {49},
  year         = {2007},
}