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Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension

Nilsson, Peter LU (2007) In Blood Pressure 16(S2). p.25-30
Abstract
Two first-line antihypertensive therapies for initiating treatment in hypertension were compared, the angiotensin-converting enzyme inhibitor (ACEI) zofenopril and the beta-blocker atenolol. The study was multi-centre and double-blind, and included 304 middle-aged to elderly patients with mild to moderate hypertension who were randomized to receive either zofenopril 30-60 mg once daily (od) or atenolol 50-100 mg od for 4 weeks with the possibility to an up-titration in non-responding patients. The higher dose level was then administered until 12 weeks after randomization. Blood pressures (BPs) were substantially reduced by either treatment, but after 4 weeks, the systolic and diastolic BP reductions were significantly greater (p < 0.05)... (More)
Two first-line antihypertensive therapies for initiating treatment in hypertension were compared, the angiotensin-converting enzyme inhibitor (ACEI) zofenopril and the beta-blocker atenolol. The study was multi-centre and double-blind, and included 304 middle-aged to elderly patients with mild to moderate hypertension who were randomized to receive either zofenopril 30-60 mg once daily (od) or atenolol 50-100 mg od for 4 weeks with the possibility to an up-titration in non-responding patients. The higher dose level was then administered until 12 weeks after randomization. Blood pressures (BPs) were substantially reduced by either treatment, but after 4 weeks, the systolic and diastolic BP reductions were significantly greater (p < 0.05) with zofenopril (-15.6/-13.5 mmHg) compared with atenolol (-13.1/-11.8 mmHg). After 12 weeks and the possibility of dose up-titration, BP differences between treatments were no longer significant. However, control rates (sitting diastolic BP < 90 mmHg) for zofenopril remained significantly higher compared with atenolol. The number of subjects with adverse drug reactions possibly or probably related to the study medication was 14 (9.1 %) in the zofenopril group and 30 (20.8%) in the atenolol group (p=0.008). It is concluded that zofenopril as well as atenolol induces substantial reductions of diastolic BP in middle-aged to elderly patients with hypertension. However, the control rate when initiating antihypertensive therapy with zofenopril is higher than that for atenolol. (Less)
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Contribution to journal
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published
subject
keywords
Adrenergic beta-Antagonists: adverse effects, Adrenergic beta-Antagonists: therapeutic use, Angiotensin-Converting Enzyme Inhibitors: adverse effects, Angiotensin-Converting Enzyme Inhibitors: therapeutic use, Atenolol: adverse effects, Atenolol: therapeutic use, Blood Pressure: drug effects, Captopril: adverse effects, Captopril: analogs & derivatives, Captopril: therapeutic use, Hypertension: drug therapy
in
Blood Pressure
volume
16
issue
S2
pages
25 - 30
publisher
Taylor & Francis
external identifiers
  • wos:000250506600005
  • pmid:18046976
  • scopus:74249117410
ISSN
0803-7051
DOI
10.1080/08038020701561745
language
English
LU publication?
yes
id
69c662dc-99a2-46b8-8b3c-2b1cca616552 (old id 654188)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18046976?dopt=Abstract
date added to LUP
2007-12-14 09:10:12
date last changed
2017-02-12 03:37:13
@article{69c662dc-99a2-46b8-8b3c-2b1cca616552,
  abstract     = {Two first-line antihypertensive therapies for initiating treatment in hypertension were compared, the angiotensin-converting enzyme inhibitor (ACEI) zofenopril and the beta-blocker atenolol. The study was multi-centre and double-blind, and included 304 middle-aged to elderly patients with mild to moderate hypertension who were randomized to receive either zofenopril 30-60 mg once daily (od) or atenolol 50-100 mg od for 4 weeks with the possibility to an up-titration in non-responding patients. The higher dose level was then administered until 12 weeks after randomization. Blood pressures (BPs) were substantially reduced by either treatment, but after 4 weeks, the systolic and diastolic BP reductions were significantly greater (p &lt; 0.05) with zofenopril (-15.6/-13.5 mmHg) compared with atenolol (-13.1/-11.8 mmHg). After 12 weeks and the possibility of dose up-titration, BP differences between treatments were no longer significant. However, control rates (sitting diastolic BP &lt; 90 mmHg) for zofenopril remained significantly higher compared with atenolol. The number of subjects with adverse drug reactions possibly or probably related to the study medication was 14 (9.1 %) in the zofenopril group and 30 (20.8%) in the atenolol group (p=0.008). It is concluded that zofenopril as well as atenolol induces substantial reductions of diastolic BP in middle-aged to elderly patients with hypertension. However, the control rate when initiating antihypertensive therapy with zofenopril is higher than that for atenolol.},
  author       = {Nilsson, Peter},
  issn         = {0803-7051},
  keyword      = {Adrenergic beta-Antagonists: adverse effects,Adrenergic beta-Antagonists: therapeutic use,Angiotensin-Converting Enzyme Inhibitors: adverse effects,Angiotensin-Converting Enzyme Inhibitors: therapeutic use,Atenolol: adverse effects,Atenolol: therapeutic use,Blood Pressure: drug effects,Captopril: adverse effects,Captopril: analogs & derivatives,Captopril: therapeutic use,Hypertension: drug therapy},
  language     = {eng},
  number       = {S2},
  pages        = {25--30},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension},
  url          = {http://dx.doi.org/10.1080/08038020701561745},
  volume       = {16},
  year         = {2007},
}