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The effect of exercise on the absorption of inhaled human insulin via the AERx insulin diabetes management system in people with type 1 diabetes

Petersen, Astrid H.; Koehler, Gerd; Korsatko, Stefan; Wutte, Andrea; Wonisch, Manfred; Jeppesen, Ole K.; Sparre, Thomas; Clauson, Per; Laursen, Torben and Wollmer, Per LU , et al. (2007) In Diabetes Care 30(10). p.2571-2576
Abstract
OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx insulin diabetes management system (iDMS). RESEARCH DESIGN AND METHODS - in this randomized, open-label, four-period crossover, glucose clamp study 23 nonsmoking subjects with type I diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either 1) no exercise (NOEX group) or 30 min exercise starting, 2) 30 min after dosing (EX30), 3) 120 min after dosing (EX120), or 4) 240 min after dosing (EX240). RESULTS - Exercise changed the shape of the free plasma insulin curves, but compared with the NOEX group the area under the curve for free plasma insulin (AUC(ins)) for the first 2 h after the... (More)
OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx insulin diabetes management system (iDMS). RESEARCH DESIGN AND METHODS - in this randomized, open-label, four-period crossover, glucose clamp study 23 nonsmoking subjects with type I diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either 1) no exercise (NOEX group) or 30 min exercise starting, 2) 30 min after dosing (EX30), 3) 120 min after dosing (EX120), or 4) 240 min after dosing (EX240). RESULTS - Exercise changed the shape of the free plasma insulin curves, but compared with the NOEX group the area under the curve for free plasma insulin (AUC(ins)) for the first 2 h after the start of exercise was unchanged for EX30 and EX240, while it was 15% decreased for EX120 (P < 0.01). The overall insulin absorption during 6 and 10 h after dosing was 13% decreased for EX30 (P < 0.005), 11% decreased for EX120 (P < 0.01), and unchanged for EX240. Exercise.), while the time to C-max was 22 min did not influence the maximum insulin concentration (C-max) earlier for EX30 (P = 0.04). The AUC for the glucose infusion rate (AUC(GIR)) for 2 h after the start of exercise increased by 58% for EX30, 45% for EX120, and 71% for EX240 (all P < 0.02) compared with the NOEX group. CONCLUSIONS - Thirty minutes of moderate exercise led to unchanged or decreased absorption of inhaled insulin via AERx iDMS and faster C-max for early exercise. Thus, patients using AERx iDMS can adjust insulin dose as usual independent of time of exercise, but they should be aware of the faster effect if exercising early after dosing. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
30
issue
10
pages
2571 - 2576
publisher
American Diabetes Association
external identifiers
  • wos:000250223400031
  • scopus:35148871706
ISSN
1935-5548
DOI
10.2337/dc06-2589
language
English
LU publication?
yes
id
18eddbe6-9013-4c6a-8052-99650a731dbe (old id 654365)
date added to LUP
2007-12-19 13:36:15
date last changed
2017-01-01 07:15:26
@article{18eddbe6-9013-4c6a-8052-99650a731dbe,
  abstract     = {OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx insulin diabetes management system (iDMS). RESEARCH DESIGN AND METHODS - in this randomized, open-label, four-period crossover, glucose clamp study 23 nonsmoking subjects with type I diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either 1) no exercise (NOEX group) or 30 min exercise starting, 2) 30 min after dosing (EX30), 3) 120 min after dosing (EX120), or 4) 240 min after dosing (EX240). RESULTS - Exercise changed the shape of the free plasma insulin curves, but compared with the NOEX group the area under the curve for free plasma insulin (AUC(ins)) for the first 2 h after the start of exercise was unchanged for EX30 and EX240, while it was 15% decreased for EX120 (P &lt; 0.01). The overall insulin absorption during 6 and 10 h after dosing was 13% decreased for EX30 (P &lt; 0.005), 11% decreased for EX120 (P &lt; 0.01), and unchanged for EX240. Exercise.), while the time to C-max was 22 min did not influence the maximum insulin concentration (C-max) earlier for EX30 (P = 0.04). The AUC for the glucose infusion rate (AUC(GIR)) for 2 h after the start of exercise increased by 58% for EX30, 45% for EX120, and 71% for EX240 (all P &lt; 0.02) compared with the NOEX group. CONCLUSIONS - Thirty minutes of moderate exercise led to unchanged or decreased absorption of inhaled insulin via AERx iDMS and faster C-max for early exercise. Thus, patients using AERx iDMS can adjust insulin dose as usual independent of time of exercise, but they should be aware of the faster effect if exercising early after dosing.},
  author       = {Petersen, Astrid H. and Koehler, Gerd and Korsatko, Stefan and Wutte, Andrea and Wonisch, Manfred and Jeppesen, Ole K. and Sparre, Thomas and Clauson, Per and Laursen, Torben and Wollmer, Per and Pieber, Thomas R.},
  issn         = {1935-5548},
  language     = {eng},
  number       = {10},
  pages        = {2571--2576},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {The effect of exercise on the absorption of inhaled human insulin via the AERx insulin diabetes management system in people with type 1 diabetes},
  url          = {http://dx.doi.org/10.2337/dc06-2589},
  volume       = {30},
  year         = {2007},
}