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Antihyperglycaemic treatment of type 2 diabetes: results from a national diabetes register

Ellasson, B.; Eeg-Olofsson, K.; Cederholm, J.; Nilsson, Peter LU and Gudbjoernsdottir, S. (2007) In Diabetes & Metabolism 33(4). p.269-276
Abstract
Aim. - To describe clinical characteristics and antihyperglycaemic treatment patterns in patients with varying duration of diabetes. Methods. - We performed a cross-sectional survey of 61 890 type 2 diabetic (DM2) patients from the Swedish National Diabetes Register (NDR) in 2004. We also analysed the effect of types of treatment and risk factors on glycaemic control in a longitudinal cohort study from 1996 to 2004. HbA(1c), risk factors and treatments were determined locally in primary care as well as hospital outpatient clinics. Results. - Insulin was frequently used in DM2 patients with long duration of diabetes, although the mean HbA(1c) increased and only a few in this group reached HbA(1c) < 7.0%. Patients showing long-term... (More)
Aim. - To describe clinical characteristics and antihyperglycaemic treatment patterns in patients with varying duration of diabetes. Methods. - We performed a cross-sectional survey of 61 890 type 2 diabetic (DM2) patients from the Swedish National Diabetes Register (NDR) in 2004. We also analysed the effect of types of treatment and risk factors on glycaemic control in a longitudinal cohort study from 1996 to 2004. HbA(1c), risk factors and treatments were determined locally in primary care as well as hospital outpatient clinics. Results. - Insulin was frequently used in DM2 patients with long duration of diabetes, although the mean HbA(1c) increased and only a few in this group reached HbA(1c) < 7.0%. Patients showing long-term improvement in HbA(1c) (> 1%) from 1996 to 2004 were more often treated with insulin than with oral hypoglycaemic agents (OHA). During this period, the HbA(1c) levels leading to additional treatment decreased. A low BMI, decreasing BMI and not smoking were predictors of good long-term metabolic control. Hypertension and hyperlipidaemia were frequent in both newly diagnosed DM2 patients and in patients with a long duration of diabetes. Conclusions. - Insulin treatment was frequently used, particularly in patients with a long duration of DM2. The glycaemic control, which usually deteriorates over time, did not reach the recommended goal, despite the fact that complementary treatment was added at lower HbA(1c) levels in 2003 than in 1996. High frequencies of hypertension, hyperlipidaemia and high 10-year risks of coronary heart disease necessitate intensified risk factor control in the future. (C) 2007 Elsevier Masson SAS. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hypoglycaemic agents, insulin, diabetes mellitus, epidemiology, hypertension, national register
in
Diabetes & Metabolism
volume
33
issue
4
pages
269 - 276
publisher
Masson Editeur
external identifiers
  • wos:000250111600005
  • scopus:34548703609
ISSN
1878-1780
DOI
10.1016/j.diabet.2007.02.003
language
English
LU publication?
yes
id
664a3fa3-4599-43ba-b5ce-8966d1fc04cf (old id 655386)
date added to LUP
2007-12-07 15:17:07
date last changed
2017-08-20 04:24:18
@article{664a3fa3-4599-43ba-b5ce-8966d1fc04cf,
  abstract     = {Aim. - To describe clinical characteristics and antihyperglycaemic treatment patterns in patients with varying duration of diabetes. Methods. - We performed a cross-sectional survey of 61 890 type 2 diabetic (DM2) patients from the Swedish National Diabetes Register (NDR) in 2004. We also analysed the effect of types of treatment and risk factors on glycaemic control in a longitudinal cohort study from 1996 to 2004. HbA(1c), risk factors and treatments were determined locally in primary care as well as hospital outpatient clinics. Results. - Insulin was frequently used in DM2 patients with long duration of diabetes, although the mean HbA(1c) increased and only a few in this group reached HbA(1c) &lt; 7.0%. Patients showing long-term improvement in HbA(1c) (&gt; 1%) from 1996 to 2004 were more often treated with insulin than with oral hypoglycaemic agents (OHA). During this period, the HbA(1c) levels leading to additional treatment decreased. A low BMI, decreasing BMI and not smoking were predictors of good long-term metabolic control. Hypertension and hyperlipidaemia were frequent in both newly diagnosed DM2 patients and in patients with a long duration of diabetes. Conclusions. - Insulin treatment was frequently used, particularly in patients with a long duration of DM2. The glycaemic control, which usually deteriorates over time, did not reach the recommended goal, despite the fact that complementary treatment was added at lower HbA(1c) levels in 2003 than in 1996. High frequencies of hypertension, hyperlipidaemia and high 10-year risks of coronary heart disease necessitate intensified risk factor control in the future. (C) 2007 Elsevier Masson SAS. All rights reserved.},
  author       = {Ellasson, B. and Eeg-Olofsson, K. and Cederholm, J. and Nilsson, Peter and Gudbjoernsdottir, S.},
  issn         = {1878-1780},
  keyword      = {hypoglycaemic agents,insulin,diabetes mellitus,epidemiology,hypertension,national register},
  language     = {eng},
  number       = {4},
  pages        = {269--276},
  publisher    = {Masson Editeur},
  series       = {Diabetes & Metabolism},
  title        = {Antihyperglycaemic treatment of type 2 diabetes: results from a national diabetes register},
  url          = {http://dx.doi.org/10.1016/j.diabet.2007.02.003},
  volume       = {33},
  year         = {2007},
}