Photodissociation of bromine-substituted nitroimidazole radiosensitizers
(2023) In Physical chemistry chemical physics : PCCP 25(18). p.13004-13011- Abstract
Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given... (More)
Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given X-ray dose, we conclude that heavy-element substitution of nitroimidazoles appears to be a viable path towards new, potent radiosensitizer drugs.
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- author
- Pihlava, Lassi ; Berholts, Marta ; Niskanen, Johannes ; Vladyka, Anton ; Kooser, Kuno ; Stråhlman, Christian LU ; Eng-Johnsson, Per LU ; Kivimäki, Antti LU and Kukk, Edwin
- organization
- publishing date
- 2023-05-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical chemistry chemical physics : PCCP
- volume
- 25
- issue
- 18
- pages
- 8 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- pmid:37165880
- scopus:85158880025
- ISSN
- 1463-9084
- DOI
- 10.1039/d2cp04888d
- language
- English
- LU publication?
- yes
- id
- 6554d90e-ba30-4c46-808a-7f55b8c2f48b
- date added to LUP
- 2023-05-26 14:29:47
- date last changed
- 2024-09-07 11:32:35
@article{6554d90e-ba30-4c46-808a-7f55b8c2f48b, abstract = {{<p>Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given X-ray dose, we conclude that heavy-element substitution of nitroimidazoles appears to be a viable path towards new, potent radiosensitizer drugs.</p>}}, author = {{Pihlava, Lassi and Berholts, Marta and Niskanen, Johannes and Vladyka, Anton and Kooser, Kuno and Stråhlman, Christian and Eng-Johnsson, Per and Kivimäki, Antti and Kukk, Edwin}}, issn = {{1463-9084}}, language = {{eng}}, month = {{05}}, number = {{18}}, pages = {{13004--13011}}, publisher = {{Royal Society of Chemistry}}, series = {{Physical chemistry chemical physics : PCCP}}, title = {{Photodissociation of bromine-substituted nitroimidazole radiosensitizers}}, url = {{http://dx.doi.org/10.1039/d2cp04888d}}, doi = {{10.1039/d2cp04888d}}, volume = {{25}}, year = {{2023}}, }