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Photodissociation of bromine-substituted nitroimidazole radiosensitizers

Pihlava, Lassi ; Berholts, Marta ; Niskanen, Johannes ; Vladyka, Anton ; Kooser, Kuno ; Stråhlman, Christian LU ; Eng-Johnsson, Per LU orcid ; Kivimäki, Antti LU and Kukk, Edwin (2023) In Physical chemistry chemical physics : PCCP 25(18). p.13004-13011
Abstract

Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given... (More)

Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given X-ray dose, we conclude that heavy-element substitution of nitroimidazoles appears to be a viable path towards new, potent radiosensitizer drugs.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical chemistry chemical physics : PCCP
volume
25
issue
18
pages
8 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:37165880
  • scopus:85158880025
ISSN
1463-9084
DOI
10.1039/d2cp04888d
language
English
LU publication?
yes
id
6554d90e-ba30-4c46-808a-7f55b8c2f48b
date added to LUP
2023-05-26 14:29:47
date last changed
2024-06-15 03:28:09
@article{6554d90e-ba30-4c46-808a-7f55b8c2f48b,
  abstract     = {{<p>Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given X-ray dose, we conclude that heavy-element substitution of nitroimidazoles appears to be a viable path towards new, potent radiosensitizer drugs.</p>}},
  author       = {{Pihlava, Lassi and Berholts, Marta and Niskanen, Johannes and Vladyka, Anton and Kooser, Kuno and Stråhlman, Christian and Eng-Johnsson, Per and Kivimäki, Antti and Kukk, Edwin}},
  issn         = {{1463-9084}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{18}},
  pages        = {{13004--13011}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Physical chemistry chemical physics : PCCP}},
  title        = {{Photodissociation of bromine-substituted nitroimidazole radiosensitizers}},
  url          = {{http://dx.doi.org/10.1039/d2cp04888d}},
  doi          = {{10.1039/d2cp04888d}},
  volume       = {{25}},
  year         = {{2023}},
}