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Electrocardiographic characteristics of fibrillatory waves in new-onset atrial fibrillation

Husser, Daniela; Cannom, David S.; Bhandari, Anil K.; Stridh, Martin LU ; Sörnmo, Leif LU ; Olsson, S. Bertil and Bollmann, Andreas (2007) In Europace 9(8). p.638-642
Abstract
Aims In atrial. fibrillation (AF), fibrillatory waves of surface electrocardiograms (ECG) vary among patients with respect to waveform and repetition rate. The purpose of this study was to (i) explore clinical determinants of new-onset AF and (ii) determine prognostic significance to predict initial treatment outcome of electrocardiographic fibrillatory wave characteristics in new-onset AF Methods and results Twenty-five patients (15 mate, mean age 69 +/- 16 years) with new-onset AF (median AF duration 8 days) were studied. Fibrillatory rate and exponential decay defined as decay of the curve that connects power maxima of dominant and harmonic frequency components were obtained by spatiotemporal. QRST cancellation and time-frequency... (More)
Aims In atrial. fibrillation (AF), fibrillatory waves of surface electrocardiograms (ECG) vary among patients with respect to waveform and repetition rate. The purpose of this study was to (i) explore clinical determinants of new-onset AF and (ii) determine prognostic significance to predict initial treatment outcome of electrocardiographic fibrillatory wave characteristics in new-onset AF Methods and results Twenty-five patients (15 mate, mean age 69 +/- 16 years) with new-onset AF (median AF duration 8 days) were studied. Fibrillatory rate and exponential decay defined as decay of the curve that connects power maxima of dominant and harmonic frequency components were obtained by spatiotemporal. QRST cancellation and time-frequency analysis of the index ECG (before treatment initiation). Baseline AF rate was 380 +/- 50 fibrillations per minute (fpm) (range 222-494); patients' age (beta = - 1.747, P = 0.003) and AF duration (beta = 0.726, P = 0.036) were independently related with fibrillatory rate. AF terminated within 24 h in seven patients, while it was persistent in the other 18 patients. Terminating AF had lower atrial. rate (333 +/- 66 vs. 398 +/- 40 fpm, P = 0.005) and exponential decay (1.03 +/- 0.36 vs. 1.40 +/- 0.37, P = 0.041) than persisting AF Multivariate analysis revealed fibrillatory rate to be the only independent predictor of AF termination or persistence (p = 0.031, P = 0.031). Sensitivity and specificity for predicting AF termination were strongly related to fibrillatory rate (area under the curve = 0.817). Sensitivity and specificity were 89% and 71% for a fibrillatory rate of 355 fpm. Conclusions Fibrillatory rates vary substantially among patients to new-onset AF and are related to patients' age and AF duration. Lower fibrillatory rates indicate higher chances of spontaneous AF termination within 24 h. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antiarrhythmic drugs, atrial fibrillation, ECG
in
Europace
volume
9
issue
8
pages
638 - 642
publisher
Oxford University Press
external identifiers
  • wos:000249915000016
  • scopus:34547943101
ISSN
1532-2092
DOI
10.1093/europace/eum074
language
English
LU publication?
yes
id
721859ee-48fb-461e-a010-f04c13358ef2 (old id 655742)
date added to LUP
2007-12-12 09:41:19
date last changed
2017-01-01 04:48:27
@article{721859ee-48fb-461e-a010-f04c13358ef2,
  abstract     = {Aims In atrial. fibrillation (AF), fibrillatory waves of surface electrocardiograms (ECG) vary among patients with respect to waveform and repetition rate. The purpose of this study was to (i) explore clinical determinants of new-onset AF and (ii) determine prognostic significance to predict initial treatment outcome of electrocardiographic fibrillatory wave characteristics in new-onset AF Methods and results Twenty-five patients (15 mate, mean age 69 +/- 16 years) with new-onset AF (median AF duration 8 days) were studied. Fibrillatory rate and exponential decay defined as decay of the curve that connects power maxima of dominant and harmonic frequency components were obtained by spatiotemporal. QRST cancellation and time-frequency analysis of the index ECG (before treatment initiation). Baseline AF rate was 380 +/- 50 fibrillations per minute (fpm) (range 222-494); patients' age (beta = - 1.747, P = 0.003) and AF duration (beta = 0.726, P = 0.036) were independently related with fibrillatory rate. AF terminated within 24 h in seven patients, while it was persistent in the other 18 patients. Terminating AF had lower atrial. rate (333 +/- 66 vs. 398 +/- 40 fpm, P = 0.005) and exponential decay (1.03 +/- 0.36 vs. 1.40 +/- 0.37, P = 0.041) than persisting AF Multivariate analysis revealed fibrillatory rate to be the only independent predictor of AF termination or persistence (p = 0.031, P = 0.031). Sensitivity and specificity for predicting AF termination were strongly related to fibrillatory rate (area under the curve = 0.817). Sensitivity and specificity were 89% and 71% for a fibrillatory rate of 355 fpm. Conclusions Fibrillatory rates vary substantially among patients to new-onset AF and are related to patients' age and AF duration. Lower fibrillatory rates indicate higher chances of spontaneous AF termination within 24 h.},
  author       = {Husser, Daniela and Cannom, David S. and Bhandari, Anil K. and Stridh, Martin and Sörnmo, Leif and Olsson, S. Bertil and Bollmann, Andreas},
  issn         = {1532-2092},
  keyword      = {antiarrhythmic drugs,atrial fibrillation,ECG},
  language     = {eng},
  number       = {8},
  pages        = {638--642},
  publisher    = {Oxford University Press},
  series       = {Europace},
  title        = {Electrocardiographic characteristics of fibrillatory waves in new-onset atrial fibrillation},
  url          = {http://dx.doi.org/10.1093/europace/eum074},
  volume       = {9},
  year         = {2007},
}