Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment
(2007) In Cephalalgia 27(10). p.1091-1093- Abstract
- The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/656189
- author
- Tfelt-Hansen, P and Edvinsson, Lars LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pharmacokinetics, migraine, variability, pharmacodynamics
- in
- Cephalalgia
- volume
- 27
- issue
- 10
- pages
- 1091 - 1093
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000249659500001
- scopus:34748846390
- ISSN
- 0333-1024
- DOI
- 10.1111/j.1468-2982.2007.01372.x
- language
- English
- LU publication?
- yes
- id
- 972a1f47-ed1d-4594-b6a0-5098321036dd (old id 656189)
- date added to LUP
- 2016-04-01 17:03:55
- date last changed
- 2024-01-11 19:59:00
@article{972a1f47-ed1d-4594-b6a0-5098321036dd, abstract = {{The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.}}, author = {{Tfelt-Hansen, P and Edvinsson, Lars}}, issn = {{0333-1024}}, keywords = {{pharmacokinetics; migraine; variability; pharmacodynamics}}, language = {{eng}}, number = {{10}}, pages = {{1091--1093}}, publisher = {{Wiley-Blackwell}}, series = {{Cephalalgia}}, title = {{Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment}}, url = {{http://dx.doi.org/10.1111/j.1468-2982.2007.01372.x}}, doi = {{10.1111/j.1468-2982.2007.01372.x}}, volume = {{27}}, year = {{2007}}, }