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Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

Tfelt-Hansen, P and Edvinsson, Lars LU (2007) In Cephalalgia 27(10). p.1091-1093
Abstract
The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pharmacokinetics, migraine, variability, pharmacodynamics
in
Cephalalgia
volume
27
issue
10
pages
1091 - 1093
publisher
Wiley-Blackwell
external identifiers
  • wos:000249659500001
  • scopus:34748846390
ISSN
0333-1024
DOI
10.1111/j.1468-2982.2007.01372.x
language
English
LU publication?
yes
id
972a1f47-ed1d-4594-b6a0-5098321036dd (old id 656189)
date added to LUP
2008-01-03 10:16:45
date last changed
2017-09-03 04:43:54
@article{972a1f47-ed1d-4594-b6a0-5098321036dd,
  abstract     = {The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.},
  author       = {Tfelt-Hansen, P and Edvinsson, Lars},
  issn         = {0333-1024},
  keyword      = {pharmacokinetics,migraine,variability,pharmacodynamics},
  language     = {eng},
  number       = {10},
  pages        = {1091--1093},
  publisher    = {Wiley-Blackwell},
  series       = {Cephalalgia},
  title        = {Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment},
  url          = {http://dx.doi.org/10.1111/j.1468-2982.2007.01372.x},
  volume       = {27},
  year         = {2007},
}