Cystatin C, beta-2-microglobulin and beta-trace protein in pre-eclampsia
Kristensen, Karl LU ; Wide-Swensson, Dag LU ; Schmidt, C. ; Blirup-Jensen, S. ; Lindström, Veronica LU
; Strevens, Helena
LU
and Grubb, Anders
LU
(2007)
In Acta Obstetricia et Gynecologica Scandinavica
86(8).
p.921-926
- Abstract
- Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level has been reported to be a reliable marker for the disease. The aim of this investigation was to study the plasma levels of beta-trace protein, beta-2-microglobulin and cystatin C in pre-eclampsia, and to determine the diagnostic performance of these proteins compared to that of urate and creatinine. Methods. A case-control study of 57 women... (More)
- Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level has been reported to be a reliable marker for the disease. The aim of this investigation was to study the plasma levels of beta-trace protein, beta-2-microglobulin and cystatin C in pre-eclampsia, and to determine the diagnostic performance of these proteins compared to that of urate and creatinine. Methods. A case-control study of 57 women diagnosed with pre-eclampsia, and 218 healthy women with uncomplicated singleton pregnancies in the third trimester. Women in the catchment area of Lund, Sweden, were included during an 18-month period from October 2003 to April 2005. Venous blood samples were drawn upon inclusion when diagnosis was made. The maternal plasma concentrations of the 3 proteins were analysed by automated particle-enhanced immunoturbidimetric assays. Results. The plasma levels of the 3 proteins were significantly higher in the third trimester of pre-eclamptic patients compared to healthy pregnant women in the third trimester. The upper reference limits ( parametric 97.5 percentile) were 2.57 mg/l for beta-2-microglobulin, 0.72 mg/l for beta-trace protein and 1.37 mg/l for cystatin C. ROC analysis showed similar diagnostic performance for the 3 proteins, with b-trace protein displaying the best diagnostic performance of all the analytes. Conclusions. In this study, the maternal plasma levels of beta 2-microglobulin, beta-trace protein and cystatin C were all significantly elevated in pre-eclampsia compared to those of healthy pregnant women, and displayed similar diagnostic performance for diagnosing pre-eclampsia. The results indicate that low molecular mass proteins are useful as markers of renal impairment in pre-eclampsia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/656316
- author
- Kristensen, Karl
LU
; Wide-Swensson, Dag
LU
; Schmidt, C.
; Blirup-Jensen, S.
; Lindström, Veronica
LU
; Strevens, Helena
LU
and Grubb, Anders
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- plasma proteins, pregnancy, creatinine, uric acid
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 86
- issue
- 8
- pages
- 921 - 926
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000249731000006
- scopus:34547198263
- ISSN
- 1600-0412
- DOI
- 10.1080/00016340701318133
- language
- English
- LU publication?
- yes
- id
- 026be221-bca4-48dc-ae17-be86bbb29940 (old id 656316)
- date added to LUP
- 2016-04-01 16:28:55
- date last changed
- 2023-03-20 04:15:35
@article{026be221-bca4-48dc-ae17-be86bbb29940,
abstract = {{Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level has been reported to be a reliable marker for the disease. The aim of this investigation was to study the plasma levels of beta-trace protein, beta-2-microglobulin and cystatin C in pre-eclampsia, and to determine the diagnostic performance of these proteins compared to that of urate and creatinine. Methods. A case-control study of 57 women diagnosed with pre-eclampsia, and 218 healthy women with uncomplicated singleton pregnancies in the third trimester. Women in the catchment area of Lund, Sweden, were included during an 18-month period from October 2003 to April 2005. Venous blood samples were drawn upon inclusion when diagnosis was made. The maternal plasma concentrations of the 3 proteins were analysed by automated particle-enhanced immunoturbidimetric assays. Results. The plasma levels of the 3 proteins were significantly higher in the third trimester of pre-eclamptic patients compared to healthy pregnant women in the third trimester. The upper reference limits ( parametric 97.5 percentile) were 2.57 mg/l for beta-2-microglobulin, 0.72 mg/l for beta-trace protein and 1.37 mg/l for cystatin C. ROC analysis showed similar diagnostic performance for the 3 proteins, with b-trace protein displaying the best diagnostic performance of all the analytes. Conclusions. In this study, the maternal plasma levels of beta 2-microglobulin, beta-trace protein and cystatin C were all significantly elevated in pre-eclampsia compared to those of healthy pregnant women, and displayed similar diagnostic performance for diagnosing pre-eclampsia. The results indicate that low molecular mass proteins are useful as markers of renal impairment in pre-eclampsia.}},
author = {{Kristensen, Karl and Wide-Swensson, Dag and Schmidt, C. and Blirup-Jensen, S. and Lindström, Veronica and Strevens, Helena and Grubb, Anders}},
issn = {{1600-0412}},
keywords = {{plasma proteins; pregnancy; creatinine; uric acid}},
language = {{eng}},
number = {{8}},
pages = {{921--926}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Obstetricia et Gynecologica Scandinavica}},
title = {{Cystatin C, beta-2-microglobulin and beta-trace protein in pre-eclampsia}},
url = {{http://dx.doi.org/10.1080/00016340701318133}},
doi = {{10.1080/00016340701318133}},
volume = {{86}},
year = {{2007}},
}