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Temporal changes of the plasma levels of cystatin C, beta-trace protein, beta(2)-microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process

Kristensen, Karl LU ; Lindström, Veronica LU ; Schmidt, C.; Blirup-Jensen, S.; Grubb, Anders LU ; Wide-Swensson, Dag LU and Strevens, Helena LU (2007) In Scandinavian Journal of Clinical & Laboratory Investigation 67(6). p.612-618
Abstract
Objective. To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta(2)-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies. Material and methods. Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta(2)-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the... (More)
Objective. To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta(2)-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies. Material and methods. Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta(2)-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the first and second trimesters. Results. The results indicate an increased filtration of low-molecular weight molecules during pregnancy, particularly during the first and second trimesters, whereas filtration of 10-30 kDa molecules is decreased in the third but unaltered in the first and second trimesters. The levels of albumin and alpha(2)-macroglobulin were measured in the same samples. Conclusions. The albumin levels decreased in the second and third trimesters, whereas the levels of alpha(2)-macroglobulin were unchanged, which is compatible with a virtually unaltered transfer of alpha(2)-macroglobulin between the intra-and extravascular space during pregnancy and a significantly increased extravascular fraction of albumin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pregnancy trimesters, plasma albumin, glomerular filtration rate, alpha2-macroglobulin, tests, kidney function
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
67
issue
6
pages
612 - 618
publisher
Informa Healthcare
external identifiers
  • wos:000249644300007
  • scopus:34547176866
ISSN
1502-7686
DOI
10.1080/00365510701203488
language
English
LU publication?
yes
id
72b3f3e7-25e1-4f6b-97d2-e626fc6496dc (old id 656376)
date added to LUP
2007-12-12 09:37:25
date last changed
2017-10-22 04:42:19
@article{72b3f3e7-25e1-4f6b-97d2-e626fc6496dc,
  abstract     = {Objective. To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta(2)-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies. Material and methods. Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta(2)-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the first and second trimesters. Results. The results indicate an increased filtration of low-molecular weight molecules during pregnancy, particularly during the first and second trimesters, whereas filtration of 10-30 kDa molecules is decreased in the third but unaltered in the first and second trimesters. The levels of albumin and alpha(2)-macroglobulin were measured in the same samples. Conclusions. The albumin levels decreased in the second and third trimesters, whereas the levels of alpha(2)-macroglobulin were unchanged, which is compatible with a virtually unaltered transfer of alpha(2)-macroglobulin between the intra-and extravascular space during pregnancy and a significantly increased extravascular fraction of albumin.},
  author       = {Kristensen, Karl and Lindström, Veronica and Schmidt, C. and Blirup-Jensen, S. and Grubb, Anders and Wide-Swensson, Dag and Strevens, Helena},
  issn         = {1502-7686},
  keyword      = {pregnancy trimesters,plasma albumin,glomerular filtration rate,alpha2-macroglobulin,tests,kidney function},
  language     = {eng},
  number       = {6},
  pages        = {612--618},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Temporal changes of the plasma levels of cystatin C, beta-trace protein, beta(2)-microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process},
  url          = {http://dx.doi.org/10.1080/00365510701203488},
  volume       = {67},
  year         = {2007},
}