Temporal changes of the plasma levels of cystatin C, beta-trace protein, beta(2)-microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process
Kristensen, Karl LU ; Lindström, Veronica LU
; Schmidt, C.
; Blirup-Jensen, S.
; Grubb, Anders
LU
; Wide-Swensson, Dag
LU
and Strevens, Helena
LU
(2007)
In Scandinavian Journal of Clinical & Laboratory Investigation
67(6).
p.612-618
- Abstract
- Objective. To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta(2)-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies. Material and methods. Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta(2)-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the... (More)
- Objective. To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta(2)-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies. Material and methods. Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta(2)-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the first and second trimesters. Results. The results indicate an increased filtration of low-molecular weight molecules during pregnancy, particularly during the first and second trimesters, whereas filtration of 10-30 kDa molecules is decreased in the third but unaltered in the first and second trimesters. The levels of albumin and alpha(2)-macroglobulin were measured in the same samples. Conclusions. The albumin levels decreased in the second and third trimesters, whereas the levels of alpha(2)-macroglobulin were unchanged, which is compatible with a virtually unaltered transfer of alpha(2)-macroglobulin between the intra-and extravascular space during pregnancy and a significantly increased extravascular fraction of albumin. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/656376
- author
- Kristensen, Karl
LU
; Lindström, Veronica
LU
; Schmidt, C.
; Blirup-Jensen, S.
; Grubb, Anders
LU
; Wide-Swensson, Dag
LU
and Strevens, Helena
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pregnancy trimesters, plasma albumin, glomerular filtration rate, alpha2-macroglobulin, tests, kidney function
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 67
- issue
- 6
- pages
- 612 - 618
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000249644300007
- scopus:34547176866
- ISSN
- 1502-7686
- DOI
- 10.1080/00365510701203488
- language
- English
- LU publication?
- yes
- id
- 72b3f3e7-25e1-4f6b-97d2-e626fc6496dc (old id 656376)
- date added to LUP
- 2016-04-01 16:32:53
- date last changed
- 2023-01-05 00:33:29
@article{72b3f3e7-25e1-4f6b-97d2-e626fc6496dc,
abstract = {{Objective. To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta(2)-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies. Material and methods. Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta(2)-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the first and second trimesters. Results. The results indicate an increased filtration of low-molecular weight molecules during pregnancy, particularly during the first and second trimesters, whereas filtration of 10-30 kDa molecules is decreased in the third but unaltered in the first and second trimesters. The levels of albumin and alpha(2)-macroglobulin were measured in the same samples. Conclusions. The albumin levels decreased in the second and third trimesters, whereas the levels of alpha(2)-macroglobulin were unchanged, which is compatible with a virtually unaltered transfer of alpha(2)-macroglobulin between the intra-and extravascular space during pregnancy and a significantly increased extravascular fraction of albumin.}},
author = {{Kristensen, Karl and Lindström, Veronica and Schmidt, C. and Blirup-Jensen, S. and Grubb, Anders and Wide-Swensson, Dag and Strevens, Helena}},
issn = {{1502-7686}},
keywords = {{pregnancy trimesters; plasma albumin; glomerular filtration rate; alpha2-macroglobulin; tests; kidney function}},
language = {{eng}},
number = {{6}},
pages = {{612--618}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Temporal changes of the plasma levels of cystatin C, beta-trace protein, beta(2)-microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process}},
url = {{http://dx.doi.org/10.1080/00365510701203488}},
doi = {{10.1080/00365510701203488}},
volume = {{67}},
year = {{2007}},
}