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The influence of patient-prosthesis mismatch on in-hospital complications and early mortality after aortic valve replacement

Nozohoor, Shahab LU ; Nilsson, Johan LU ; Lührs, Carsten LU ; Roijer, Anders LU and Sjögren, Johan LU (2007) In Journal of Heart Valve Disease 16(5). p.475-482
Abstract
Background and aim of the study: The study aim was to analyze the relationship between patient-prosthesis mismatch (PPM) and in-hospital complications and mortality after aortic valve replacement (AVR). Methods: AVR was performed in 1,819 patients between January 1996 and July 2006. Follow up investigations were performed after a mean of 4.3 years (range: 0 days to 10.6 years). Univariate and multivariate analysis were used to evaluate risk factors for in-hospital complications and mortality in patients with prosthesis mismatch. Actuarial statistics were used to calculate survival rates. Results: Multivariate analysis showed that PPM (defined as indexed effective orifice area 0.85 cm(2)/m(2)) was associated with an increased risk of... (More)
Background and aim of the study: The study aim was to analyze the relationship between patient-prosthesis mismatch (PPM) and in-hospital complications and mortality after aortic valve replacement (AVR). Methods: AVR was performed in 1,819 patients between January 1996 and July 2006. Follow up investigations were performed after a mean of 4.3 years (range: 0 days to 10.6 years). Univariate and multivariate analysis were used to evaluate risk factors for in-hospital complications and mortality in patients with prosthesis mismatch. Actuarial statistics were used to calculate survival rates. Results: Multivariate analysis showed that PPM (defined as indexed effective orifice area 0.85 cm(2)/m(2)) was associated with an increased risk of postoperative neurological events (OR 2.26, 95% Cl 1.05-4.83, p = 0.037). There were no significant differences in 30-day mortality between the PPM and nonPPM groups. Neither was any significant difference found between the two groups regarding long-term survival adjusted for significant risk factors for death after AVR. Conclusion: The results suggest PPM to be an independent predictor of postoperative neurological complications in patients undergoing AVR. However, PPM did not negatively influence either short- or long-term survival. PPM may play an important role in selected categories of patients, and should be considered in order to avoid postoperative neurological complications. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Heart Valve Disease
volume
16
issue
5
pages
475 - 482
publisher
ICR Publishers
external identifiers
  • wos:000249625000004
  • scopus:34948905374
ISSN
0966-8519
language
English
LU publication?
yes
id
7f71ec68-69b4-435c-a412-40c40f3dc02b (old id 656535)
alternative location
http://www.icr-heart.com/journal/content/2007/sept/abstracts/article.php?id=4
date added to LUP
2007-12-14 11:58:23
date last changed
2017-01-01 07:05:34
@article{7f71ec68-69b4-435c-a412-40c40f3dc02b,
  abstract     = {Background and aim of the study: The study aim was to analyze the relationship between patient-prosthesis mismatch (PPM) and in-hospital complications and mortality after aortic valve replacement (AVR). Methods: AVR was performed in 1,819 patients between January 1996 and July 2006. Follow up investigations were performed after a mean of 4.3 years (range: 0 days to 10.6 years). Univariate and multivariate analysis were used to evaluate risk factors for in-hospital complications and mortality in patients with prosthesis mismatch. Actuarial statistics were used to calculate survival rates. Results: Multivariate analysis showed that PPM (defined as indexed effective orifice area 0.85 cm(2)/m(2)) was associated with an increased risk of postoperative neurological events (OR 2.26, 95% Cl 1.05-4.83, p = 0.037). There were no significant differences in 30-day mortality between the PPM and nonPPM groups. Neither was any significant difference found between the two groups regarding long-term survival adjusted for significant risk factors for death after AVR. Conclusion: The results suggest PPM to be an independent predictor of postoperative neurological complications in patients undergoing AVR. However, PPM did not negatively influence either short- or long-term survival. PPM may play an important role in selected categories of patients, and should be considered in order to avoid postoperative neurological complications.},
  author       = {Nozohoor, Shahab and Nilsson, Johan and Lührs, Carsten and Roijer, Anders and Sjögren, Johan},
  issn         = {0966-8519},
  language     = {eng},
  number       = {5},
  pages        = {475--482},
  publisher    = {ICR Publishers},
  series       = {Journal of Heart Valve Disease},
  title        = {The influence of patient-prosthesis mismatch on in-hospital complications and early mortality after aortic valve replacement},
  volume       = {16},
  year         = {2007},
}