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The binax NOW test as a tool for diagnosis of severe acute otitis media and associated complications

Gisselsson-Solén, Marie LU ; Bylander, Anita; Wilhelmsson, Christina; Hermansson, Ann LU and Melhus, Åsa LU (2007) In Journal of Clinical Microbiology 45(9). p.3003-3007
Abstract
The diagnosis of acute otitis media (AOM) is often difficult, depending heavily on the experience and skills of the examiner. However, it is important to identify episodes of AOM that involve the risk of complications and to treat these episodes appropriately. The present study was performed in order to evaluate the use of a rapid antigen assay for Streptococcus pneumoniae, the Binax NOW test, as a diagnostic tool in patients with severe AOM and associated complications. The study included 70 patients with 74 episodes of AOM, 18 of them with complications. Cultures, Binax NOW tests, and a PCR assay were performed on nasopharyngeal secretions, middle ear fluid, and in some cases mastoid bone, cerebrospinal fluid, and urine. According to... (More)
The diagnosis of acute otitis media (AOM) is often difficult, depending heavily on the experience and skills of the examiner. However, it is important to identify episodes of AOM that involve the risk of complications and to treat these episodes appropriately. The present study was performed in order to evaluate the use of a rapid antigen assay for Streptococcus pneumoniae, the Binax NOW test, as a diagnostic tool in patients with severe AOM and associated complications. The study included 70 patients with 74 episodes of AOM, 18 of them with complications. Cultures, Binax NOW tests, and a PCR assay were performed on nasopharyngeal secretions, middle ear fluid, and in some cases mastoid bone, cerebrospinal fluid, and urine. According to culture and PCR of the middle ear fluid, 30 (41%) of the episodes were caused by S. pneumoniae. The Binax NOW test was positive in 24 of these episodes (80%). It identified pneumococcal AOM independent of antibiotic treatment, and it was easily adapted to bone tissue. The test yielded sensitivity, specificity, and positive and negative predictive values for middle ear specimens of 85%, 100%, 100%, and 89%, respectively. The corresponding positive and negative values for predicting the bacterial etiology with nasopharyngeal secretions were 51% and 75%. This study showed that the Binax NOW test is a useful diagnostic tool for patients with severe AOM with or without complications. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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in
Journal of Clinical Microbiology
volume
45
issue
9
pages
3003 - 3007
publisher
American Society for Microbiology
external identifiers
  • wos:000249506900038
  • scopus:34548675347
ISSN
1098-660X
DOI
10.1128/JCM.00299-07
language
English
LU publication?
yes
id
868ec1da-4220-4b6a-9a48-18073f3c596d (old id 656557)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17634299&dopt=Abstract
date added to LUP
2007-12-07 12:15:55
date last changed
2017-01-01 06:53:13
@article{868ec1da-4220-4b6a-9a48-18073f3c596d,
  abstract     = {The diagnosis of acute otitis media (AOM) is often difficult, depending heavily on the experience and skills of the examiner. However, it is important to identify episodes of AOM that involve the risk of complications and to treat these episodes appropriately. The present study was performed in order to evaluate the use of a rapid antigen assay for Streptococcus pneumoniae, the Binax NOW test, as a diagnostic tool in patients with severe AOM and associated complications. The study included 70 patients with 74 episodes of AOM, 18 of them with complications. Cultures, Binax NOW tests, and a PCR assay were performed on nasopharyngeal secretions, middle ear fluid, and in some cases mastoid bone, cerebrospinal fluid, and urine. According to culture and PCR of the middle ear fluid, 30 (41%) of the episodes were caused by S. pneumoniae. The Binax NOW test was positive in 24 of these episodes (80%). It identified pneumococcal AOM independent of antibiotic treatment, and it was easily adapted to bone tissue. The test yielded sensitivity, specificity, and positive and negative predictive values for middle ear specimens of 85%, 100%, 100%, and 89%, respectively. The corresponding positive and negative values for predicting the bacterial etiology with nasopharyngeal secretions were 51% and 75%. This study showed that the Binax NOW test is a useful diagnostic tool for patients with severe AOM with or without complications.},
  author       = {Gisselsson-Solén, Marie and Bylander, Anita and Wilhelmsson, Christina and Hermansson, Ann and Melhus, Åsa},
  issn         = {1098-660X},
  language     = {eng},
  number       = {9},
  pages        = {3003--3007},
  publisher    = {American Society for Microbiology},
  series       = {Journal of Clinical Microbiology},
  title        = {The binax NOW test as a tool for diagnosis of severe acute otitis media and associated complications},
  url          = {http://dx.doi.org/10.1128/JCM.00299-07},
  volume       = {45},
  year         = {2007},
}