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Characterizing microbial exposure with ergosterol, 3-hydroxy fatty acids, and viable microbes in house dust: Determinants and association with childhood asthma

Hyvarinen, Anne ; Sebastian, Aleksandra LU ; Pekkanen, Juha ; Larsson, Lennart LU ; Korppi, Matti ; Putus, Tuula and Nevalainen, Aino (2006) In Archives of Environmental & Occupational Health 61(4). p.149-157
Abstract
The authors assessed determinants of ergosterol, 3-OH fatty acids (FAs), and viable microbes in vacuum cleaner dust, and investioated the association between these microbial markets and childhood asthma. The authors studied the homes of 36 children who were new cases of childhood asthma and the homes of 36 controls. Home characteristics explained 34% to 44% of the variation in levels of different microbial groups. Determinants of 3-OH FAs were a lower level of cleanliness, having a fireplace, having livestock, and moisture damage; determinants of viable bacteria were the level of home repair needed and the material used in the building frame of the home. Ergosterol was associated with the presence of livestock and the practice of cleaning... (More)
The authors assessed determinants of ergosterol, 3-OH fatty acids (FAs), and viable microbes in vacuum cleaner dust, and investioated the association between these microbial markets and childhood asthma. The authors studied the homes of 36 children who were new cases of childhood asthma and the homes of 36 controls. Home characteristics explained 34% to 44% of the variation in levels of different microbial groups. Determinants of 3-OH FAs were a lower level of cleanliness, having a fireplace, having livestock, and moisture damage; determinants of viable bacteria were the level of home repair needed and the material used in the building frame of the home. Ergosterol was associated with the presence of livestock and the practice of cleaning rugs outside; viable fungi was associated with the material used in the building frame, visible mold, and the practice of cleaning rugs Outside. Exposure to mesophilic actinonnycetes was nonsignificantly associated with risk of asthma. The authors Concluded that the variation of microbial levels in dust could be explained relatively well by home characteristics, and suggested that exposure to mesophilic actinomycetes may increase the risk of new asthma. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ergosterol, dust, determinants, 3-OH fatty acids, asthma, microbes
in
Archives of Environmental & Occupational Health
volume
61
issue
4
pages
149 - 157
publisher
Heldref Publications
external identifiers
  • wos:000248672600002
  • scopus:34548185701
ISSN
1933-8244
DOI
10.3200/AEOH.61.4.149-157
language
English
LU publication?
yes
id
f8d326b8-53f4-420f-891f-2690403c1f92 (old id 656743)
date added to LUP
2016-04-01 16:38:14
date last changed
2021-02-17 04:48:56
@article{f8d326b8-53f4-420f-891f-2690403c1f92,
  abstract     = {The authors assessed determinants of ergosterol, 3-OH fatty acids (FAs), and viable microbes in vacuum cleaner dust, and investioated the association between these microbial markets and childhood asthma. The authors studied the homes of 36 children who were new cases of childhood asthma and the homes of 36 controls. Home characteristics explained 34% to 44% of the variation in levels of different microbial groups. Determinants of 3-OH FAs were a lower level of cleanliness, having a fireplace, having livestock, and moisture damage; determinants of viable bacteria were the level of home repair needed and the material used in the building frame of the home. Ergosterol was associated with the presence of livestock and the practice of cleaning rugs outside; viable fungi was associated with the material used in the building frame, visible mold, and the practice of cleaning rugs Outside. Exposure to mesophilic actinonnycetes was nonsignificantly associated with risk of asthma. The authors Concluded that the variation of microbial levels in dust could be explained relatively well by home characteristics, and suggested that exposure to mesophilic actinomycetes may increase the risk of new asthma.},
  author       = {Hyvarinen, Anne and Sebastian, Aleksandra and Pekkanen, Juha and Larsson, Lennart and Korppi, Matti and Putus, Tuula and Nevalainen, Aino},
  issn         = {1933-8244},
  language     = {eng},
  number       = {4},
  pages        = {149--157},
  publisher    = {Heldref Publications},
  series       = {Archives of Environmental & Occupational Health},
  title        = {Characterizing microbial exposure with ergosterol, 3-hydroxy fatty acids, and viable microbes in house dust: Determinants and association with childhood asthma},
  url          = {http://dx.doi.org/10.3200/AEOH.61.4.149-157},
  doi          = {10.3200/AEOH.61.4.149-157},
  volume       = {61},
  year         = {2006},
}