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Simulation of stroke-related damage in cultured human nerve cells

Bicker, Gerd; Gierse, Andrea; Tan, Saime and Paquet-Durand, Francois LU (2007) In ALTEX Alternatives To Animal Experimentation 24. p.16-18
Abstract
We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
reduction, organ-specific, brain-cell cultures, human, neuroprotection, neural differentiation, ischaemia, excitotoxicity, glutamate, replacement, pharmacological testing
in
ALTEX Alternatives To Animal Experimentation
volume
24
pages
16 - 18
publisher
Spektrum Akad Verlag
external identifiers
  • wos:000249535100007
  • scopus:70350731409
ISSN
0946-7785
language
English
LU publication?
yes
id
5026337d-c55c-475f-8ba5-e7f70f97b895 (old id 656822)
date added to LUP
2007-12-10 11:39:11
date last changed
2017-01-01 05:11:33
@article{5026337d-c55c-475f-8ba5-e7f70f97b895,
  abstract     = {We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.},
  author       = {Bicker, Gerd and Gierse, Andrea and Tan, Saime and Paquet-Durand, Francois},
  issn         = {0946-7785},
  keyword      = {reduction,organ-specific,brain-cell cultures,human,neuroprotection,neural differentiation,ischaemia,excitotoxicity,glutamate,replacement,pharmacological testing},
  language     = {eng},
  pages        = {16--18},
  publisher    = {Spektrum Akad Verlag},
  series       = {ALTEX Alternatives To Animal Experimentation},
  title        = {Simulation of stroke-related damage in cultured human nerve cells},
  volume       = {24},
  year         = {2007},
}