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Evaluation of phenoxymethylpenicillin treatment of acute otitis media in children aged 2-16

Neumark, Thomas ; Molstad, Sigvard ; Rosen, Christer ; Persson, Lars-Goran ; Torngren, Annika ; Brudin, Lars and Eliasson, Ingvar LU (2007) In Scandinavian Journal of Primary Health Care 25(3). p.166-171
Abstract
Objective. To study the clinical recovery from acute otitis media ( AOM) in children, 2-16 years of age, managed with or without treatment with phenoxymethylpenicillin ( PcV). Design. An open, prospective randomized trial. Children aged between 2 and 16 years, presenting with one- or double-sided AOM ( without perforation) with symptom duration of less than four days, were included. The children were randomized to PcV for five days or to no primary antibiotic treatment. A health score and compliance were registered on a daily basis for seven days. Setting. A total of 32 health centres and 72 GPs in south-east Sweden. Subjects. Children aged 2-16 presenting with earache. Main outcome measures. Recovery time, symptom duration, frequency of... (More)
Objective. To study the clinical recovery from acute otitis media ( AOM) in children, 2-16 years of age, managed with or without treatment with phenoxymethylpenicillin ( PcV). Design. An open, prospective randomized trial. Children aged between 2 and 16 years, presenting with one- or double-sided AOM ( without perforation) with symptom duration of less than four days, were included. The children were randomized to PcV for five days or to no primary antibiotic treatment. A health score and compliance were registered on a daily basis for seven days. Setting. A total of 32 health centres and 72 GPs in south-east Sweden. Subjects. Children aged 2-16 presenting with earache. Main outcome measures. Recovery time, symptom duration, frequency of complications ( up to three months) and consumption of healthcare services independent of treatment with or without antibiotics. Results. A total of 179 patients carried out the trial; 92 were randomized to PcV, 87 to no primary antibiotic treatment. The median recovery time was four days in both groups. Patients who received PcV had less pain ( p<0.001) and used fewer analgesics. There were no significant differences in the number of middle-ear effusions or perforations at the final control after three months. Children randomized to PcV treatment consulted less ( p<0.001) during the first seven days. Conclusions. Our investigation supports that PcV treatment of AOM does not affect the recovery time or complication rates. PcV provided some symptomatic benefit in the treatment of AOM in otherwise healthy children, aged 2-16 years. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
phenoxymethylpenicillin, PcV, general practice, family practice, children, AOM, acute otitis media, antibiotics, primary healthcare
in
Scandinavian Journal of Primary Health Care
volume
25
issue
3
pages
166 - 171
publisher
Taylor & Francis
external identifiers
  • wos:000249341400008
  • scopus:34548584008
  • pmid:17846935
ISSN
0281-3432
DOI
10.1080/02813430701267405
language
English
LU publication?
yes
id
f9c3c66c-790c-41d5-af44-76be8a2d7bd2 (old id 656911)
date added to LUP
2016-04-01 12:17:16
date last changed
2022-02-11 04:58:45
@article{f9c3c66c-790c-41d5-af44-76be8a2d7bd2,
  abstract     = {{Objective. To study the clinical recovery from acute otitis media ( AOM) in children, 2-16 years of age, managed with or without treatment with phenoxymethylpenicillin ( PcV). Design. An open, prospective randomized trial. Children aged between 2 and 16 years, presenting with one- or double-sided AOM ( without perforation) with symptom duration of less than four days, were included. The children were randomized to PcV for five days or to no primary antibiotic treatment. A health score and compliance were registered on a daily basis for seven days. Setting. A total of 32 health centres and 72 GPs in south-east Sweden. Subjects. Children aged 2-16 presenting with earache. Main outcome measures. Recovery time, symptom duration, frequency of complications ( up to three months) and consumption of healthcare services independent of treatment with or without antibiotics. Results. A total of 179 patients carried out the trial; 92 were randomized to PcV, 87 to no primary antibiotic treatment. The median recovery time was four days in both groups. Patients who received PcV had less pain ( p&lt;0.001) and used fewer analgesics. There were no significant differences in the number of middle-ear effusions or perforations at the final control after three months. Children randomized to PcV treatment consulted less ( p&lt;0.001) during the first seven days. Conclusions. Our investigation supports that PcV treatment of AOM does not affect the recovery time or complication rates. PcV provided some symptomatic benefit in the treatment of AOM in otherwise healthy children, aged 2-16 years.}},
  author       = {{Neumark, Thomas and Molstad, Sigvard and Rosen, Christer and Persson, Lars-Goran and Torngren, Annika and Brudin, Lars and Eliasson, Ingvar}},
  issn         = {{0281-3432}},
  keywords     = {{phenoxymethylpenicillin; PcV; general practice; family practice; children; AOM; acute otitis media; antibiotics; primary healthcare}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{166--171}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Primary Health Care}},
  title        = {{Evaluation of phenoxymethylpenicillin treatment of acute otitis media in children aged 2-16}},
  url          = {{http://dx.doi.org/10.1080/02813430701267405}},
  doi          = {{10.1080/02813430701267405}},
  volume       = {{25}},
  year         = {{2007}},
}