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Autonomic and orthostatic dysfunction in primary Sjögren's syndrome

Mandl, Thomas LU ; Wollmer, Per LU ; Manthorpe, Rolf LU and Jacobsson, Lennart LU (2007) In Journal of Rheumatology 34(9). p.1869-1874
Abstract
Objective. Exocrine function always is and autonomic nervous function may be impaired in primary Sjögren's syndrome (pSS). Since autonomic nervous signaling is a prerequisite for exocrine secretion we wanted to assess autonomic nervous function in pSS and relate it to diagnostic measures of exocrine function. Methods. Autonomic nervous function was determined in 46 patients with pSS using the deep breathing test [expiration/inspiration (E/I) ratio], orthostatic test [acceleration index (AI), orthostatic systolic and diastolic blood pressure response (ISBP ratio and IDBP ratio)], and finger skin blood flow test [vasoconstrictory (VAC) score]. The results were corrected for age and expressed as z-scores by comparison with 3 control groups... (More)
Objective. Exocrine function always is and autonomic nervous function may be impaired in primary Sjögren's syndrome (pSS). Since autonomic nervous signaling is a prerequisite for exocrine secretion we wanted to assess autonomic nervous function in pSS and relate it to diagnostic measures of exocrine function. Methods. Autonomic nervous function was determined in 46 patients with pSS using the deep breathing test [expiration/inspiration (E/I) ratio], orthostatic test [acceleration index (AI), orthostatic systolic and diastolic blood pressure response (ISBP ratio and IDBP ratio)], and finger skin blood flow test [vasoconstrictory (VAC) score]. The results were corrected for age and expressed as z-scores by comparison with 3 control groups (E/I ratio and AI, n = 56; ISBP ratio and IDBP ratio, n = 238; and VAC score, n = 80). Exocrine gland function was determined in patients with pSS using the objective functional Schirmer-I test and rose-bengal staining (van Bijsterveld score) for the lacrimal glands and unstimulated whole sialometry for the salivary glands. Results. The E/I ratio and orthostatic systolic and diastolic blood pressures were significantly decreased and the VAC score was significantly increased in patients with pSS compared to controls, indicating both parasympathetic and sympathetic dysfunction. Autonomic and exocrine function measures were found to associate poorly. Conclusion. Patients with pSS showed signs of both parasympathetic and sympathetic dysfunction. However, an association between cardiovascular autonomic and exocrine function in pSS was not detected. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autonomic nervous dysfunction, primary Sjögren's syndrome
in
Journal of Rheumatology
volume
34
issue
9
pages
1869 - 1874
publisher
J Rheumatol Publ Co
external identifiers
  • wos:000249284300016
ISSN
0315-162X
language
English
LU publication?
yes
id
62bc501e-4ad9-41d3-81df-8d0581739166 (old id 657133)
alternative location
http://www.jrheum.com/abstracts/abstracts07/1869.html
date added to LUP
2007-12-13 12:31:06
date last changed
2016-04-15 20:24:54
@article{62bc501e-4ad9-41d3-81df-8d0581739166,
  abstract     = {Objective. Exocrine function always is and autonomic nervous function may be impaired in primary Sjögren's syndrome (pSS). Since autonomic nervous signaling is a prerequisite for exocrine secretion we wanted to assess autonomic nervous function in pSS and relate it to diagnostic measures of exocrine function. Methods. Autonomic nervous function was determined in 46 patients with pSS using the deep breathing test [expiration/inspiration (E/I) ratio], orthostatic test [acceleration index (AI), orthostatic systolic and diastolic blood pressure response (ISBP ratio and IDBP ratio)], and finger skin blood flow test [vasoconstrictory (VAC) score]. The results were corrected for age and expressed as z-scores by comparison with 3 control groups (E/I ratio and AI, n = 56; ISBP ratio and IDBP ratio, n = 238; and VAC score, n = 80). Exocrine gland function was determined in patients with pSS using the objective functional Schirmer-I test and rose-bengal staining (van Bijsterveld score) for the lacrimal glands and unstimulated whole sialometry for the salivary glands. Results. The E/I ratio and orthostatic systolic and diastolic blood pressures were significantly decreased and the VAC score was significantly increased in patients with pSS compared to controls, indicating both parasympathetic and sympathetic dysfunction. Autonomic and exocrine function measures were found to associate poorly. Conclusion. Patients with pSS showed signs of both parasympathetic and sympathetic dysfunction. However, an association between cardiovascular autonomic and exocrine function in pSS was not detected.},
  author       = {Mandl, Thomas and Wollmer, Per and Manthorpe, Rolf and Jacobsson, Lennart},
  issn         = {0315-162X},
  keyword      = {autonomic nervous dysfunction,primary Sjögren's syndrome},
  language     = {eng},
  number       = {9},
  pages        = {1869--1874},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {Autonomic and orthostatic dysfunction in primary Sjögren's syndrome},
  volume       = {34},
  year         = {2007},
}