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The Mhc class II of the Black grouse (Tetrao tetrix) consists of low numbers of B and Y genes with variable diversity and expression

Strand, Tanja; Westerdahl, Helena LU ; Hoglund, Jacob; Alatalo, Rauno V. and Siitari, Heli (2007) In Immunogenetics 59(9). p.725-734
Abstract
We found that the Black grouse (Tetrao tetrix) possess low numbers of Mhc class II B (BLB) and Y (YLB) genes with variable diversity and expression. We have therefore shown, for the first time, that another bird species (in this case, a wild lek-breeding galliform) shares several features of the simple Mhc of the domestic chicken (Gallus gallus). The Black grouse BLB genes showed the same level of polymorphism that has been reported in chicken, and we also found indications of balancing selection in the peptide-binding regions. The YLB genes were less variable than the BLB genes, also in accordance with earlier studies in chicken, although their functional significance still remains obscure. We hypothesize that the YLB genes could have... (More)
We found that the Black grouse (Tetrao tetrix) possess low numbers of Mhc class II B (BLB) and Y (YLB) genes with variable diversity and expression. We have therefore shown, for the first time, that another bird species (in this case, a wild lek-breeding galliform) shares several features of the simple Mhc of the domestic chicken (Gallus gallus). The Black grouse BLB genes showed the same level of polymorphism that has been reported in chicken, and we also found indications of balancing selection in the peptide-binding regions. The YLB genes were less variable than the BLB genes, also in accordance with earlier studies in chicken, although their functional significance still remains obscure. We hypothesize that the YLB genes could have been under purifying selection, just as the mammal Mhc-E gene cluster. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Rfp-Y, BLB, purifying selection, avian Mhc, Mhc class II, YLB
in
Immunogenetics
volume
59
issue
9
pages
725 - 734
publisher
Springer
external identifiers
  • wos:000249503200004
  • scopus:34548699489
ISSN
1432-1211
DOI
10.1007/s00251-007-0234-6
language
English
LU publication?
yes
id
a5d05870-270b-4027-8cb3-b505ee003b12 (old id 657339)
date added to LUP
2008-01-03 08:53:50
date last changed
2017-05-14 04:14:03
@article{a5d05870-270b-4027-8cb3-b505ee003b12,
  abstract     = {We found that the Black grouse (Tetrao tetrix) possess low numbers of Mhc class II B (BLB) and Y (YLB) genes with variable diversity and expression. We have therefore shown, for the first time, that another bird species (in this case, a wild lek-breeding galliform) shares several features of the simple Mhc of the domestic chicken (Gallus gallus). The Black grouse BLB genes showed the same level of polymorphism that has been reported in chicken, and we also found indications of balancing selection in the peptide-binding regions. The YLB genes were less variable than the BLB genes, also in accordance with earlier studies in chicken, although their functional significance still remains obscure. We hypothesize that the YLB genes could have been under purifying selection, just as the mammal Mhc-E gene cluster.},
  author       = {Strand, Tanja and Westerdahl, Helena and Hoglund, Jacob and Alatalo, Rauno V. and Siitari, Heli},
  issn         = {1432-1211},
  keyword      = {Rfp-Y,BLB,purifying selection,avian Mhc,Mhc class II,YLB},
  language     = {eng},
  number       = {9},
  pages        = {725--734},
  publisher    = {Springer},
  series       = {Immunogenetics},
  title        = {The Mhc class II of the Black grouse (Tetrao tetrix) consists of low numbers of B and Y genes with variable diversity and expression},
  url          = {http://dx.doi.org/10.1007/s00251-007-0234-6},
  volume       = {59},
  year         = {2007},
}