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Oxidized lipoprotein autoimmunity: an emerging drug target in cardiovascular disease

Nilsson, Jan LU ; Nordin Fredrikson, Gunilla LU ; Chyu, Kuang-Yuh ; Shah, Prediman K. and Björkbacka, Harry LU orcid (2006) In Future Lipidology 1(3). p.321-330
Abstract
Oxidative modification of low-density lipoprotein (LDL) in the arterial wall is believed to be one of the most important mechanisms involved in the development of atherosclerosis. It is well established that oxidized (Ox)-LDL uptake is responsible for the formation of macrophage foam cells, one of the most characteristic hallmarks of the atherosclerotic plaque, and that the proinflammatory and cytotoxic effects of Ox-LDL play an important role in vascular inflammation and lesion development. More recently, it has become apparent that Ox-LDL is also recognized by the immune system, thus resulting in innate and adaptive immune reactions modulating both Ox-LDL clearance and the vascular inflammatory response. The finding that some of these... (More)
Oxidative modification of low-density lipoprotein (LDL) in the arterial wall is believed to be one of the most important mechanisms involved in the development of atherosclerosis. It is well established that oxidized (Ox)-LDL uptake is responsible for the formation of macrophage foam cells, one of the most characteristic hallmarks of the atherosclerotic plaque, and that the proinflammatory and cytotoxic effects of Ox-LDL play an important role in vascular inflammation and lesion development. More recently, it has become apparent that Ox-LDL is also recognized by the immune system, thus resulting in innate and adaptive immune reactions modulating both Ox-LDL clearance and the vascular inflammatory response. The finding that some of these immune responses have a protective effect against plaque development has focused attention on the potential to develop novel therapies for the prevention and treatment of cardiovascular disease based on the selective activation of this protective immunity by vaccines, or mimicking them directly by using Ox-LDL-specific antibodies. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antigen-presenting cells, antibodies, atherosclerosis, heat shock, immunomodulation, proteins, T cells, oxidized LDL
in
Future Lipidology
volume
1
issue
3
pages
321 - 330
publisher
Future Medicine Ltd.
external identifiers
  • wos:000249427400015
ISSN
1746-0875
DOI
10.2217/17460875.1.3.321
language
English
LU publication?
yes
id
825df506-39be-4696-9be7-5afe3007c621 (old id 657360)
date added to LUP
2016-04-01 17:12:35
date last changed
2019-03-08 03:19:51
@article{825df506-39be-4696-9be7-5afe3007c621,
  abstract     = {Oxidative modification of low-density lipoprotein (LDL) in the arterial wall is believed to be one of the most important mechanisms involved in the development of atherosclerosis. It is well established that oxidized (Ox)-LDL uptake is responsible for the formation of macrophage foam cells, one of the most characteristic hallmarks of the atherosclerotic plaque, and that the proinflammatory and cytotoxic effects of Ox-LDL play an important role in vascular inflammation and lesion development. More recently, it has become apparent that Ox-LDL is also recognized by the immune system, thus resulting in innate and adaptive immune reactions modulating both Ox-LDL clearance and the vascular inflammatory response. The finding that some of these immune responses have a protective effect against plaque development has focused attention on the potential to develop novel therapies for the prevention and treatment of cardiovascular disease based on the selective activation of this protective immunity by vaccines, or mimicking them directly by using Ox-LDL-specific antibodies.},
  author       = {Nilsson, Jan and Nordin Fredrikson, Gunilla and Chyu, Kuang-Yuh and Shah, Prediman K. and Björkbacka, Harry},
  issn         = {1746-0875},
  language     = {eng},
  number       = {3},
  pages        = {321--330},
  publisher    = {Future Medicine Ltd.},
  series       = {Future Lipidology},
  title        = {Oxidized lipoprotein autoimmunity: an emerging drug target in cardiovascular disease},
  url          = {http://dx.doi.org/10.2217/17460875.1.3.321},
  doi          = {10.2217/17460875.1.3.321},
  volume       = {1},
  year         = {2006},
}