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hTERT T-1327/C polymorphism is not associated with age-related telomere attrition in peripheral blood

Nordfjall, Katarina; Osterman, Pia; Melander, Olle LU ; Nilsson, Peter LU and Roos, Goran (2007) In Biochemical and Biophysical Research Communications 358(1). p.215-218
Abstract
Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations. Recently, a functional T to C transition polymorphisin was indicated 1327 bp upstream the hTERT transcription starting site. The C-1327/C genotype was associated with shorter telomere length compared to the alternative genotypes in healthy individuals and in coronary artery disease patients. We tested this observation and analysed telomere length and the T-1327/C polymorphism in 226 myocardial infarction patients and 444 controls from southern Sweden. No significant difference in telomere length was found among the... (More)
Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations. Recently, a functional T to C transition polymorphisin was indicated 1327 bp upstream the hTERT transcription starting site. The C-1327/C genotype was associated with shorter telomere length compared to the alternative genotypes in healthy individuals and in coronary artery disease patients. We tested this observation and analysed telomere length and the T-1327/C polymorphism in 226 myocardial infarction patients and 444 controls from southern Sweden. No significant difference in telomere length was found among the genotypes after age adjustments in the control group (p = 0.794) or in the MI group (p = 0.339). Moreover, no increased age-related attrition was observed for the C-1327/C genotype as previously indicated, rather a telomere elongation in the control group (p = 0.021) not seen in the MI group (P = 0.249). (c) 2007 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polymorphism, telomere length, hTERT, age, myocardial infarction
in
Biochemical and Biophysical Research Communications
volume
358
issue
1
pages
215 - 218
publisher
Elsevier
external identifiers
  • wos:000246790800036
  • scopus:34248177465
ISSN
1090-2104
DOI
10.1016/j.bbrc.2007.04.099
language
English
LU publication?
yes
id
df15014a-1a57-40d3-88db-624302c39356 (old id 657927)
date added to LUP
2007-12-14 09:58:30
date last changed
2017-06-18 04:28:33
@article{df15014a-1a57-40d3-88db-624302c39356,
  abstract     = {Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations. Recently, a functional T to C transition polymorphisin was indicated 1327 bp upstream the hTERT transcription starting site. The C-1327/C genotype was associated with shorter telomere length compared to the alternative genotypes in healthy individuals and in coronary artery disease patients. We tested this observation and analysed telomere length and the T-1327/C polymorphism in 226 myocardial infarction patients and 444 controls from southern Sweden. No significant difference in telomere length was found among the genotypes after age adjustments in the control group (p = 0.794) or in the MI group (p = 0.339). Moreover, no increased age-related attrition was observed for the C-1327/C genotype as previously indicated, rather a telomere elongation in the control group (p = 0.021) not seen in the MI group (P = 0.249). (c) 2007 Elsevier Inc. All rights reserved.},
  author       = {Nordfjall, Katarina and Osterman, Pia and Melander, Olle and Nilsson, Peter and Roos, Goran},
  issn         = {1090-2104},
  keyword      = {polymorphism,telomere length,hTERT,age,myocardial infarction},
  language     = {eng},
  number       = {1},
  pages        = {215--218},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {hTERT T-1327/C polymorphism is not associated with age-related telomere attrition in peripheral blood},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2007.04.099},
  volume       = {358},
  year         = {2007},
}